thealthЗдравоохранение ТаджикистанаHealth care of Tajikistan0514-2415Редакция журнала «Здравоохранение Таджикистана»thealth-230Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWАКТУАЛЬНОСТЬ ЗАБОЛЕВАЕМОСТИ ВРОЖДЕННЫМИ ПОРОКАМИ РАЗВИТИЯRELEVANCE OF INCIDENTAL DEVELOPMENTAL DISORDERSНабиеваШ. З.NabievaSh. Z.

Набиева Шахноза Зохировна – соискатель

Nabieva Shahnoza Zohirovna - Applicant

shaha.92@mail.ruГУ «Республиканский научно клинический центр педиатрии и детской хирургии» Республики ТаджикистанТаджикистанState Institution «Republican Scientific Clinical Center of Pediatrics and Pediatric Surgery»Tajikistan202025082021037883Copyright © Набиева Ш.З., 20212021Набиева Ш.З.Nabieva S.Z.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.zdrav.tj/jour/article/view/230

В статье приведен обзор современной литературы с целью изучения вопросов этиологии, факторы риска, профилактики, выявлении и современном лечении врожденных пороков развития.

Исследования доказали, что основные профилактические мероприятия по снижению рождения детей с пороками развития и улучшения состояния здоровья беременных женщин должны быть направлены на совершенствование диагностических технологий и решение медико-социальных проблем беременных женщин.

The article provides a review of modern literature in order to study the issues of etiology, risk factors, prevention, detection and modern treatment of congenital malformations.

Studies have shown that the main preventive measures to reduce the birth of children with developmental defects and improve the health status of pregnant women should be aimed at improving diagnostic technologies and solving medical and social problems of pregnant women.

детиврожденные пороки развитияпороки развитияврожденные аномалииВПРВПСchildrencongenital malformationsmalformationscongenital anomaliescongenital malformationscongenital heart diseaseReferencesБузрукова Н.Д. Некоторые аспекты врождённых пороков развития новорождённых детей / Н.Д. Бузрукова, Р.Х. Саидмурадова, К.К. Махкамов, Ф.К. Олимова // Известия Академии наук Республики Таджикистан. Отделение биологических и медицинских наук. – 2015. - №1(189). – С. 64-68.Buzrukova N.D. Nekotorie aspekti vrojdennikh porokov razvitiya novorojdennikh detey [Some aspects of congenital malformations of newborn children]. Izvestiya Akademii nauk Respubliki Tadjikistan. Otdelenie biologicheskikh I medicinskikh nauk - Bulletin of the Academy of Sciences of the Republic of Tajikistan. Department of Biological and Medical Sciences. - 2015. - №1(189). – P. 64-68.Додхоева М. Ф. Медико-социальные аспекты врождённых пороков развития новорождённых / М. Ф. Додхоева, В. Ю. Мельникова // Доклады Академии наук Республики Таджикистан. – 2013. - №1. – С.72-77.Dodhoeva M.F. Mediko-socialnie aspekti vrojdennikh porokov razvitiya novorojdennikh [Medical and social aspects of congenital malformations of newborns]. Dokladi Akademii nauk Respubliki Tadjikistan - Reports of the Academy of Sciences of the Republic of Tajikistan – 2013. - №1. – P.72-77.Сарсенбаева Г.И. Редкие врожденные заболевания в детской кардиохирургии / Г.И. Сарсенбаева, А.И. Ким, А.К. Тулебаева // Здравоохранение Таджикистана. – 2019. – №2 (341). – С.71-77.Sarsenbaeva G.I. Redkie vrojdennie zabolevaniya v detskoy kardiokhirurgii [Rare congenital diseases in pediatric cardiac surgery]. Zdravookhraneniya Tadzhikistana – Health care of Tajikistan. – 2019. – №2 (341). – P.71-77.Тихомирова Н.А. Роль факторов среды обитания в развитии врожденных пороков / Н.А. Тихомирова, И.Ф. Колпащикова // Вестник РУДН. Серия: Экология и безопасность жизнедеятельности. - 2008. - №3. – С.70-74.Tikhomirova N.A. Rol faktorov sredy obitaniya v razvitii vrozhdennykh porokov [The role of environmental factors in the development of congenital malformations]. Vestnik RUDN. Seriya: Ekologiya i bezopasnost zhiznedeyatelnosti - Bulletin of RUDN. Series: Ecology and life safety. - 2008. - №3. – P.70-74Шамсов Б.А. Роль ультразвуковой диагностики при врожденных пороках сердца у детей / Б.А. Шамсов, М.А. Хусейнова // Материалы I-го съезда Ассоциации детских хирургов Центральной Азии и I-го съезда РОО «Казахстанские детские хирурги»: сб. статей. – Алматы, 2019. – С. 182-183.Shamsov B.A. Rol ultrazvukovoy diagnostiki pri vrozhdennykh porokakh serdtsa u detey [The role of ultrasound diagnostics in congenital heart disease in children]. Materialy I-go syezda Assotsiatsii detskikh khirurgov Tsentralnoy Azii i I-go syezda ROO «Kazakhstanskiye detskiye khirurgi» - Materials of the 1st Congress of the Association of Pediatric Surgeons of Central Asia and the 1st Congress of the Regional Public Organization «Kazakhstani Children’s Surgeons»: collection of articles. articles. - Almaty, 2019. - P. 182-183.Шипилова Л.М. Анализ структуры врожденных пороков развития у новорожденных за последние 5 лет (2014 - 2018гг.) / Л.М. Шипилова, Старчикова Т.А. // Российский вестник перинатологии и педиатрии. – 2019. - №4. – С. 230-231.Shipilova L.M. Analiz struktury vrozhdennykh porokov razvitiya u novorozhdennykh za posledniye 5 let (2014 - 2018gg.) [Analysis of the structure of congenital malformations in newborns over the past 5 years (2014 - 2018)]. Rossiyskiy vestnik perinatologii i pediatrii - Russian Bulletin of Perinatology and Pediatrics. – 2019. - №4. – P. 230-231.Янковская Н.И. Возможные факторы риска возникновения врожденных пороков развития у новорожденных в современных экологических условиях // Современные проблемы гигиены, радиационной и экологической медицины. – 2014. - №4. – С. 342-345.Yankovskaya N.I. Vozmozhnyye faktory riska vozniknoveniya vrozhdennykh porokov razvitiya u novorozhdennykh v sovremennykh ekologicheskikh usloviyakh [Possible risk factors for the occurrence of congenital malformations in newborns in modern environmental conditions]. Sovremennyye problemy gigiyeny, radiatsionnoy i ekologicheskoy meditsiny - Modern problems of hygiene, radiation and environmental medicine. - 2014. - №4. – P. 342-345.Agha MM et al. Determinants of survival in children with congenital abnormalities: a long-term populationbased cohort study. Birth defects research Part A, Clinical and molecular teratology 2006;76:46-54.Agha MM et al. Determinants of survival in children with congenital abnormalities: a long-term populationbased cohort study. Birth defects research Part A, Clinical and molecular teratology 2006;76:46-54.Aghaz F, Ojagh SZ, Khanjari S, Vaisi-Raygani A, Khazaei M, Bakhtiari M. The Contingent Prenatal Screening Test for Down’s Syndrome and Neural Tube Defects in West of Iran. J Reprod Infertil. 2019;20(4):244-251.Aghaz F, Ojagh SZ, Khanjari S, Vaisi-Raygani A, Khazaei M, Bakhtiari M. The Contingent Prenatal Screening Test for Down’s Syndrome and Neural Tube Defects in West of Iran. J Reprod Infertil. 2019;20(4):244-251.Anthony S, Kateman H, Brand R, et al. Ethnic differences in congenital malformations in the Netherlands: analyses of a 5-year birth cohort. Paediatr Perinat Epidemiol. 2005;19(2):135-144. doi:10.1111/j.1365-3016.2005.00632.xAnthony S, Kateman H, Brand R, et al. Ethnic differences in congenital malformations in the Netherlands: analyses of a 5-year birth cohort. Paediatr Perinat Epidemiol. 2005;19(2):135-144. doi:10.1111/j.1365-3016.2005.00632.xBiri A et al. Birth prevalence and distribution of congenital anomalies in a university hospital. PerinatolDergisi 2005;13:86-90.Biri A et al. Birth prevalence and distribution of congenital anomalies in a university hospital. PerinatolDergisi 2005;13:86-90.Boyle B, Addor M-C, Arriola L, et al. Estimating global burden of disease due to congenital anomaly: an analysis of European data. Arch Dis Child Fetal Neonatal Ed 2018;103:F22–F28. 10.1136/archdischild-2016-311845.Boyle B, Addor M-C, Arriola L, et al. Estimating global burden of disease due to congenital anomaly: an analysis of European data. Arch Dis Child Fetal Neonatal Ed 2018;103:F22–F28. 10.1136/archdischild-2016-311845.Brent RL. Environmental causes of human congenital malformations: the pediatrician’s role in dealing with these complex clinical problems caused by a multiplicity of environmental and genetic factors. Pediatrics. 2004;113(4 Suppl):957-968.Brent RL. Environmental causes of human congenital malformations: the pediatrician’s role in dealing with these complex clinical problems caused by a multiplicity of environmental and genetic factors. Pediatrics. 2004;113(4 Suppl):957-968.Centers for Disease C, Prevention. Improved national prevalence estimates for 18 selected major birth defects--United States, 1999-2001. MMWR Morbidity and mortality weekly report 2006;54:1301-5.Centers for Disease C, Prevention. Improved national prevalence estimates for 18 selected major birth defects--United States, 1999-2001. MMWR Morbidity and mortality weekly report 2006;54:1301-5.Chan Margaret. World Health Organization. 2nd rev. ed Geneva, Switzerland: Elsiveier; 2015; 267 p.Chan Margaret. World Health Organization. 2nd rev. ed Geneva, Switzerland: Elsiveier; 2015; 267 p.Christianson A, Howson CP, Modell B. March of dimes: global report on birth defects, the hidden toll of dying and disabled children. 1st ed USA: March of Dimes Birth Defects Found; 2005. 84 p.Christianson A, Howson CP, Modell B. March of dimes: global report on birth defects, the hidden toll of dying and disabled children. 1st ed USA: March of Dimes Birth Defects Found; 2005. 84 p.Corsello G, Giuffrè M. Congenital malformations. J Matern Fetal Neonatal Med. 2012;25 Suppl 1:25-29. doi :10.3109/14767058.2012.664943Corsello G, Giuffrè M. Congenital malformations. J Matern Fetal Neonatal Med. 2012;25 Suppl 1:25-29. doi :10.3109/14767058.2012.664943Diamandopoulos K, Green J. Down syndrome: an integrative review. J Neonatal Nurs. 2018;24(5): 235–41.Diamandopoulos K, Green J. Down syndrome: an integrative review. J Neonatal Nurs. 2018;24(5): 235–41.EUROSTAT. Population projections - tables. 2019. [Online] https://ec.europa.eu/eurostat/web/population-demography-migration-projections/data/main-tables. [accessed 29.04.2020.]EUROSTAT. Population projections - tables. 2019. [Online] https://ec.europa.eu/eurostat/web/population-demography-migration-projections/data/main-tables. [accessed 29.04.2020.]Goetzinger KR, Shanks AL, Odibo AO, Macones GA, Cahill AG. Advanced maternal age and the risk of major congenital anomalies. Am J Perinatol. 2017;34(3):217–22.Goetzinger KR, Shanks AL, Odibo AO, Macones GA, Cahill AG. Advanced maternal age and the risk of major congenital anomalies. Am J Perinatol. 2017;34(3):217–22.Goley SM, Sakula-Barry S, Kelly A, Wright N. Investigating the use of ultrasonography for the antenatal diagnosis of structural congenital anomalies in low-income and middle-income countries: systematic review protocol. BMJ Paediatr Open. 2019;3(1):e000538. Published 2019 Sep 13. doi:10.1136/bmjpo-2019-000538Goley SM, Sakula-Barry S, Kelly A, Wright N. Investigating the use of ultrasonography for the antenatal diagnosis of structural congenital anomalies in low-income and middle-income countries: systematic review protocol. BMJ Paediatr Open. 2019;3(1):e000538. Published 2019 Sep 13. doi:10.1136/bmjpo-2019-000538Kalter H. Teratology in the 20th century: environmental causes of congenital malformations in humans and how they were established. Neurotoxicol Teratol. 2003;25(2):131-282.Kalter H. Teratology in the 20th century: environmental causes of congenital malformations in humans and how they were established. Neurotoxicol Teratol. 2003;25(2):131-282.Liu L, Oza S, Hogan D, Perin J, Rudan I, Lawn JE, et al. Global, regional, and national causes of child mortality in 2000–13, with projections to inform post2015 priorities: an updated systematic analysis. Lancet. 2015;385:430–40.Liu L, Oza S, Hogan D, Perin J, Rudan I, Lawn JE, et al. Global, regional, and national causes of child mortality in 2000–13, with projections to inform post2015 priorities: an updated systematic analysis. Lancet. 2015;385:430–40.Ndibazza J, Lule S, Nampijja M, Mpairwe H, Oduru G, Kiggundu M, et al. A description of congenital anomalies among infants in Entebbe, Uganda. Birt Defects Res A Clin Mol Teratol. 2011;91:857–61.Ndibazza J, Lule S, Nampijja M, Mpairwe H, Oduru G, Kiggundu M, et al. A description of congenital anomalies among infants in Entebbe, Uganda. Birt Defects Res A Clin Mol Teratol. 2011;91:857–61.Oestergaard MZ, Inoue M, Yoshida S, Mahanani WR, Gore FM, Cousens S, et al. Neonatal mortality levels for 193 countries in 2009 with trends since 1990: a systematic analysis of Progress, projections, and priorities. PLoS Med. 2011;8:e1001080Oestergaard MZ, Inoue M, Yoshida S, Mahanani WR, Gore FM, Cousens S, et al. Neonatal mortality levels for 193 countries in 2009 with trends since 1990: a systematic analysis of Progress, projections, and priorities. PLoS Med. 2011;8:e1001080Pfeifer U, Gubler D, Bergstraesser E, Bassler D. Congenital malformations, palliative care and postnatal redirection to more intensive treatment - a review at a Swiss tertiary center. J Matern Fetal Neonatal Med. 2018;31(9):1182-1187. doi:10.1080/14767058.2017.1311317Pfeifer U, Gubler D, Bergstraesser E, Bassler D. Congenital malformations, palliative care and postnatal redirection to more intensive treatment - a review at a Swiss tertiary center. J Matern Fetal Neonatal Med. 2018;31(9):1182-1187. doi:10.1080/14767058.2017.1311317Rajangam S et al. Consanguinity and chromosomal abnormality in mental retardation and or multiple congenital anomaly. Journal of the Anatomical Society of India 2007;56:30-3.Rajangam S et al. Consanguinity and chromosomal abnormality in mental retardation and or multiple congenital anomaly. Journal of the Anatomical Society of India 2007;56:30-3.Sitkin NA, Ozgediz D, Donkor P, Farmer DL. Congenital anomalies in low- and middle-income countries: the unborn child of global surgery. World J Surg. 2015;39:36–40.Sitkin NA, Ozgediz D, Donkor P, Farmer DL. Congenital anomalies in low- and middle-income countries: the unborn child of global surgery. World J Surg. 2015;39:36–40.Taksande A, Vilhekar K, Chaturvedi P, Jain M. Congenital malformations at birth in Central India: a rural medical college hospital based data. Indian J Hum Genet. 2010;16:159.Taksande A, Vilhekar K, Chaturvedi P, Jain M. Congenital malformations at birth in Central India: a rural medical college hospital based data. Indian J Hum Genet. 2010;16:159.Temtamy S et al. A genetic epidemiological study of malformations at birth in Egypt. Eastern Mediterranean Health journal 1998;4:252-9.Temtamy S et al. A genetic epidemiological study of malformations at birth in Egypt. Eastern Mediterranean Health journal 1998;4:252-9.WHO. WHO | Congenital anomalies WHO 2016. http://www.who.int/mediacentre/factsheets/fs370/en/. Accessed 7 May 2017.WHO. WHO | Congenital anomalies WHO 2016. http://www.who.int/mediacentre/factsheets/fs370/en/. Accessed 7 May 2017.Wittekindt B, Schloesser R, Doberschuetz N, et al. Epidemiology and Outcome of Major Congenital Malformations in a Large German County. Eur J Pediatr Surg. 2019;29(3):282-289. doi:10.1055/s-0038-1642630Wittekindt B, Schloesser R, Doberschuetz N, et al. Epidemiology and Outcome of Major Congenital Malformations in a Large German County. Eur J Pediatr Surg. 2019;29(3):282-289. doi:10.1055/s-0038-1642630Wright NJ; Global PaedSurg Research Collaboration. Management and outcomes of gastrointestinal congenital anomalies in low, middle- and high-income countries: protocol for a multicentre, international, prospective cohort study. BMJ Open. 2019;9(8):e030452. Published 2019 Sep 3. doi:10.1136/bmjopen-2019-030452.Wright NJ; Global PaedSurg Research Collaboration. Management and outcomes of gastrointestinal congenital anomalies in low, middle- and high-income countries: protocol for a multicentre, international, prospective cohort study. BMJ Open. 2019;9(8):e030452. Published 2019 Sep 3. doi:10.1136/bmjopen-2019-030452.

The authors declare that there are no conflicts of interest present.