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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">thealth</journal-id><journal-title-group><journal-title xml:lang="ru">Здравоохранение Таджикистана</journal-title><trans-title-group xml:lang="en"><trans-title>Health care of Tajikistan</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0514-2415</issn><publisher><publisher-name>Редакция журнала «Здравоохранение Таджикистана»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52888/0514-2515-2022-352-1-54-60</article-id><article-id custom-type="elpub" pub-id-type="custom">thealth-343</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Каримова Д.Г. Клиническая характеристика SARS-CoV-2 ассоциированных летальных пневмоний у беременных</article-title><trans-title-group xml:lang="en"><trans-title>Clinical characteristics of SARS-COV-2 associated lethal pneumonia in pregnant women</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каримова</surname><given-names>Д. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Karimova</surname><given-names>D. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каримова Давлатби Гулбидиновна - соискатель кафедры акушерства и гинекологии №1</p></bio><bio xml:lang="en"><p>Davlatbi Gulbidinovna Karimova - fellow of the Department of Obstetrics and Gynecology №1</p><p> </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГОУ “ТГМУ им. Абуали ибни Сино”</institution><country>Таджикистан</country></aff><aff xml:lang="en"><institution>SEI Avicenna Tajik State Medical University</institution><country>Tajikistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>29</day><month>04</month><year>2022</year></pub-date><volume>0</volume><issue>1</issue><fpage>54</fpage><lpage>60</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Каримова Д.Г., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Каримова Д.Г.</copyright-holder><copyright-holder xml:lang="en">Karimova D.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.zdrav.tj/jour/article/view/343">https://www.zdrav.tj/jour/article/view/343</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования. Снижение показателей материнской смертности путем изучения клинических особенностей течения летальных SARS-COV-2-ассоциированных пневмоний у беременных с целью последующей оптимизации диагностики, акушерской тактики и лечения</p><p>Материал и методы исследования. Было обследовано 70 беременных женщин: со среднетяжёлым – 34 (48,6%), тяжёлым – 11 (15,7%) и крайне тяжёлым течением – 25 (35,7%) SARS-CoV-2. Объём исследования соответствовал стандарту обследования беременных при коронавирусной инфекции SARS-CoV-2. От общего числа обследованных в 7 случаях (1%) заболевание закончилось летально.</p><p>Результаты исследования и их обсуждение. Основными симптомами летальных случаев пневмоний, которые проявлялись с первых дней начала заболевания и стремительно прогрессировали были: повышение температуры тела до уровня фебрильных величин от момента начала заболевания – 7 (100%), выраженная слабость – 7 (100%), нарастающий сухой и малопродуктивный кашель – 7 (100%). Нарастающая одышка и тахипноэ при госпитализации в стационар также определялись у всех погибших беременных. Боли в грудной клетке преобладали у большинства 4 (57,1±20,2%) погибших беременных. Симптомы интоксикации были выражены и проявлялись артралгией – 4 (57,1±20,2%), миалгией – 3 (42,9±20,2%), головная болью – 3 (42,9±20,2%). Токсическое поражение сердечно-сосудистой системы проявлялось тахикардией 7(100%) и гипотонией в 4 (57,1±20,2%) случаях.</p></sec><sec><title>Вывод</title><p>Вывод. Особенностью клинических симптомов летальных SARS-CoV-2-ассоциированных пневмоний у беременных во второй половине гестации следует считать сочетание фебрильной лихорадки, малопродуктивного кашля, нарастающей одышки и тахипноэ.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To reduce maternal mortality by examining the clinical features of the course of lethal SARS-COV-2-associated pneumonia in pregnant women to further optimize diagnosis, obstetric management, and treatment.</p></sec><sec><title>Material and Methods</title><p>Material and Methods. 70 pregnant women were examined: 34 (48.6%) with moderate, 11 (15.7%) with severe, and 25 (35.7%) with extremely severe SARS-CoV-2. The scope of the study corresponded to the standard examination of pregnant women with SARS-CoV-2 coronavirus infection. Of the total number examined, 7 cases (1%) were fatal.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. The main symptoms of lethal cases of pneumonia, which manifested from the first days of the disease and progressed rapidly were: an increase in body temperature to febrile values from the beginning of the disease - 7 (100%), marked weakness - 7 (100%), increasing dry and unproductive cough - 7 (100%). Increasing dyspnea and tachypnea on admission to the hospital were also determined in all pregnant women who died. Chest pain predominated in the majority, 4 (57.1±20.2%) of the pregnant women who died. The symptoms of intoxication were pronounced and manifested as arthralgia - 4 (57.1±20.2%), myalgia - 3 (42.9±20.2%), headache - 3 (42.9±20.2%). Toxic lesion of the cardiovascular system was manifested by tachycardia in 7(100%) and hypotension in 4 (57,1±20,2%) cases.</p></sec><sec><title>Conclusion</title><p>Conclusion. The combination of febrile fever, low-productive cough, increasing dyspnea, and tachypnea should be considered as specific clinical symptoms of lethal SARS-CoV-2-associated pneumonia in pregnant women in the second half of gestation.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>вирусные пневмонии и беременность</kwd><kwd>коронавирусные инфекции</kwd><kwd>SARS-CoV-2</kwd><kwd>респираторные вирусные инфекции</kwd><kwd>материнская смертность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>viral pneumonia and pregnancy</kwd><kwd>coronavirus infections</kwd><kwd>SARS-CoV-2</kwd><kwd>respiratory viral infections</kwd><kwd>maternal mortality</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Белокриницкая Т.Е. Тяжелые формы гриппа у беременных: факторы риска, особенности клинического течения, профилактика / Т.Е. Белокриницкая, Д.А. Тарбаева, А.Ю. 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