thealthЗдравоохранение ТаджикистанаHealth care of Tajikistan0514-2415Редакция журнала «Здравоохранение Таджикистана»10.52888/0514-2515-2022-355-4-122-127thealth-420Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWВлияние беременности на аллосенсибилизацию у женщин с хронической болезнью почек пятой стадииImpact of pregnancy on allosensitization in women with stage 5 chronic kidney diseaseУсмоновИ. М.UsmonovI. M.

соискатель кафедра аллергологии и иммунологии ИПОвСЗ РТ

fellow of Allergology and Immunology Department, Institute for Postgraduate Education in Health Care of the Republic of Tajikistan

vorux.92@mail.ruНациональный научный центр трансплантации органов и тканей человека МЗиСЗН РТРоссияNational Scientific Center for Human Organ and Tissue Transplantation, Ministry of Health and Health Care of the Republic of TajikistanRussian Federation20221802202304122127Copyright © Усмонов И.М., 20232023Усмонов И.М.Usmonov I.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.zdrav.tj/jour/article/view/420

Статья посвящена проблеме влияние беременности на аллосенсибилизацию у женщин с хронической болезнью почек пятой стадии и выбора для её донора и имунносупресии для аллотрансплантации почки. Анализ показал, что аллоиммунизация беременных - обычное явление, и до сих пор остается малоизученным. Исследования показывают, что эндогенные механизмы, которые способствуют материнской толерантности плода во время беременности, могут сохраняться и в послеродовой жизни. И предстоит определить, можно ли использовать это иммунологическое равновесие для улучшения результатов трансплантации. Таким образом, для клинических исследователей остаются значительные возможности внести свой вклад в эту область и улучшить результаты трансплантации для женщин с сенсибилизацией. 

The article is devoted to the problem of the effect of pregnancy on alloimmunization in women with stage 5 chronic kidney disease and the choice of a donor and immunosuppression for kidney allotransplantation. The analysis showed that alloimmunization of pregnant women is common and remains poorly studied. Studies suggest that endogenous mechanisms contributing to maternal-fetal tolerance during pregnancy may persist in the postpartum period. Moreover, it remains to be determined whether this immunological balance can be used to improve transplant outcomes. Thus, significant opportunities remain for clinical researchers to contribute to this field and improve transplant outcomes for sensitized women. 

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The authors declare that there are no conflicts of interest present.