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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">thealth</journal-id><journal-title-group><journal-title xml:lang="ru">Здравоохранение Таджикистана</journal-title><trans-title-group xml:lang="en"><trans-title>Health care of Tajikistan</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0514-2415</issn><publisher><publisher-name>Редакция журнала «Здравоохранение Таджикистана»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52888/0514-2515-2024-360-1-26-34</article-id><article-id custom-type="elpub" pub-id-type="custom">thealth-528</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Определение степени обсеменнёности брюшной полости и морфологическая характеристика печени у экспериментальных животных при моделировании абсцесса и после санации антисептиками (экспериментальное исследование)</article-title><trans-title-group xml:lang="en"><trans-title>Determination of the degree of contamination of the abdominal cavity and morphological characteristics of the liver in experimental animals during simulation of an abscess and after sanitation with antiseptics</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Махмадзода</surname><given-names>Ф. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Mahmadzoda</surname><given-names>F. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Махмадзода Фарух Исроилович – д.м.н., профессор, профессор кафедры,</p><p>Душанбе.</p></bio><bio xml:lang="en"><p>Mahmadzoda Farukh Isroil – Doctor of medical sciences, professor,</p><p>Dushanbe.</p></bio><email xlink:type="simple">fmahmadov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джураев</surname><given-names>М. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Juraev</surname><given-names>М. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Душанбе.</p></bio><bio xml:lang="en"><p>Dushanbe.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Садуллоев</surname><given-names>Д. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Sadulloev</surname><given-names>D. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Душанбе.</p></bio><bio xml:lang="en"><p>Dushanbe.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тагайкулов</surname><given-names>Э. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Tagaykulov</surname><given-names>E. H.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Душанбе.</p></bio><bio xml:lang="en"><p>Dushanbe.</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абдуллоев</surname><given-names>З. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Abdulloev</surname><given-names>Z. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Душанбе.</p></bio><bio xml:lang="en"><p>Dushanbe.</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бахромов</surname><given-names>М. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Bahromov</surname><given-names>М. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Душанбе.</p></bio><bio xml:lang="en"><p>Dushanbe.</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рузиев</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Ruziev</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Душанбе.</p></bio><bio xml:lang="en"><p>Dushanbe.</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ходжагелдиева</surname><given-names>З. У.</given-names></name><name name-style="western" xml:lang="en"><surname>Khojageldieva</surname><given-names>Z. U.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Душанбе.</p></bio><bio xml:lang="en"><p>Dushanbe.</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ашуров</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Ashurov</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Душанбе.</p></bio><bio xml:lang="en"><p>Dushanbe.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГОУ «ТГМУ им. Абуали ибни Сино», Кафедра хирургических болезней №1 им. академика К.М. Курбонова</institution><country>Таджикистан</country></aff><aff xml:lang="en"><institution>State Educational Institution “Avicenna Tajik State Medical University”, Department of Surgical Diseases №1 named after Academician K.M. Kurbonov</institution><country>Tajikistan</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГУ Институт гастроэнтерологии Республики Таджикистан</institution><country>Таджикистан</country></aff><aff xml:lang="en"><institution>State Institution “Institute of Gastroenterology of the Republic of Tajikistan”</institution><country>Tajikistan</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГОУ «ТГМУ им. Абуали ибни Сино», Научно-исследовательский институт фундаментальных наук</institution><country>Таджикистан</country></aff><aff xml:lang="en"><institution>State Educational Institution “Avicenna Tajik State Medical University”, Research Institute of Basic Sciences</institution><country>Tajikistan</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГУ Научно-исследовательский институт профилактической медицины МЗ и СЗН РТ</institution><country>Таджикистан</country></aff><aff xml:lang="en"><institution>State Institution “Research Institute of Preventive Medicine”</institution><country>Tajikistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>16</day><month>05</month><year>2024</year></pub-date><volume>0</volume><issue>1</issue><fpage>26</fpage><lpage>34</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Махмадзода Ф.И., Джураев М.Ф., Садуллоев Д.Н., Тагайкулов Э.Х., Абдуллоев З.Р., Бахромов М.Б., Рузиев М.М., Ходжагелдиева З.У., Ашуров А.С., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Махмадзода Ф.И., Джураев М.Ф., Садуллоев Д.Н., Тагайкулов Э.Х., Абдуллоев З.Р., Бахромов М.Б., Рузиев М.М., Ходжагелдиева З.У., Ашуров А.С.</copyright-holder><copyright-holder xml:lang="en">Mahmadzoda F.I., Juraev М.F., Sadulloev D.N., Tagaykulov E.H., Abdulloev Z.R., Bahromov М.B., Ruziev M.M., Khojageldieva Z.U., Ashurov A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.zdrav.tj/jour/article/view/528">https://www.zdrav.tj/jour/article/view/528</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования. Изучить обсеменённость брюшной полости и морфологическую характеристику печени у экспериментальных животных при моделировании абсцесса и после санации антисептиками.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Проведены микробиологические исследования 54-х образцов гноя и 54 образца экссудата, доставленные из полости ВБА, моделированного у экспериментальных подопытных кроликов – самцов породы Шиншилла, для обнаружения штаммов микроорганизмов группы энтеробактерий и микробов кокковой флоры. Кролики были разделены на 9 групп, что каждая группа состояло из 6-ти кроликов. Также изучено морфологическая характеристика печени 24 кролика при санации брюшной полости раствором 0,1% фурагина после 3,5 и 7-минутной экспозиции. В 1-ую группу вошли 8 интактных кроликов, которые не подвергались каким-либо экспериментальным вмешательствам, 2-ая группа состояла из 8 кроликов, у которых был создан экспериментальный абсцесс, но не проводилась его санация. Третья группа включала 8 кроликов где использовался 0,1% раствор фурагина для санации абсцесса с различными интервалами экспозиции: 3, 5 и 7 минут.</p></sec><sec><title>Результаты</title><p>Результаты. Исследования, относительно роста микробов после различных экспозиций санации 0,1% раствором фурагина, показало, что антисептический раствор 0,1% фурагина оказывает губительное действие на микробов полости ВБА и брюшной полости, в частности в экспозиции 5-7 минут практически уничтожает все существующие микробы. А микроскопические исследования ткани печени после 7-минутной экспозиции применением 0,1% антисептического раствора фурагина – изменения не выявили.</p></sec><sec><title>Заключение</title><p>Заключение. 0,1% раствор фурагина обладает бактерицидными свойствами, является наиболее безопасным и не имеет токсического действия на ткань печени.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To study the contamination of the abdominal cavity and the morphological characteristics of the liver in experimental animals when modeling an abscess and after sanitation with antiseptics.</p></sec><sec><title>Material and methods</title><p>Material and methods. Microbiological studies were carried out on 54 samples of pus and 54 samples of exudate, delivered from the cavity of the SMA, modeled in experimental experimental rabbits - male Chinchillas, to detect strains of microorganisms of the group of enterobacteria and microbes of the coccal flora. The rabbits were divided into 9 groups, each group consisting of 6 rabbits. The morphological characteristics of the liver of 24 rabbits were also studied during sanitation of the abdominal cavity with a solution of 0.1% furagin after 3.5 and 7 minutes of exposure. The 1st group included 8 intact rabbits that were not subjected to any experimental interventions, the 2nd group consisted of 8 rabbits in which an experimental abscess was created, but its sanitation was not carried out. The third group included 8 rabbits where a 0.1% furagin solution was used to sanitation an abscess with different exposure intervals: 3, 5 and 7 minutes.</p></sec><sec><title>Results</title><p>Results. Studies regarding the growth of microbes after various exposures to sanitation with a 0.1% furagin solution have shown that the antiseptic solution of 0.1% furagin has a detrimental effect on the microbes of the abscess cavity and abdominal cavity, in particular, in an exposure of 5-7 minutes it practically destroys all existing microbes. And microscopic studies of liver tissue after a 7-minute exposure to the use of a 0.1% antiseptic solution of furagin did not reveal any changes.</p></sec><sec><title>Conclusion</title><p>Conclusion. A 0.1% solution of furagin has bactericidal properties, is the safest and has no toxic effect on liver tissue.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>внутрибрюшные абсцессы</kwd><kwd>обсеменённость брюшной полости</kwd><kwd>0</kwd><kwd>1% раствор фурагина</kwd><kwd>морфология печени</kwd></kwd-group><kwd-group xml:lang="en"><kwd>intra-abdominal abscesses</kwd><kwd>contamination of the abdominal cavity</kwd><kwd>0.1% furagin solution</kwd><kwd>liver morphology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гельфанд Б.Р. Абдоминальная хирургическая инфекция: Российские национальные рекомендации / Б.Р. Гельфанд, А.И. Кириенко, Н.Н. Хачатрян. – 2-е изд., перераб. и доп. – М: ООО «Медицинское информационное агентство», 2018. – 168 с.: ил..</mixed-citation><mixed-citation xml:lang="en">Gel’fand, B.R. Abdominal’naya hirurgicheskaya infekciya: Rossijskie nacional’nye rekomendacii [Abdominal surgical infection: Russian national recommendations]. 2-e izd., pererab. i dop. – M: OOO «Medicinskoe informacionnoe agentstvo», 2018, 168 s.: il..</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Кулабухов В.В. Сепсис: контроль очага инфекции / В.В. Кулабухов, Н.А. Зубарева, П.А. Ярцев // Вестник анестезиологии и реаниматологии. – 2021. – Т.18, №5. – С. 89-96.</mixed-citation><mixed-citation xml:lang="en">Kulabuhov, V.V. Sepsis: kontrol’ ochaga infekcii [Sepsis: controlling the source of infection]. Vestnik anesteziologii i reanimatologii, 2021, No. 5(18), рр. 89-96.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Микробный пейзаж оперированных больных с ограниченным стерильным панкреонекрозом в различные периоды комплексного лечения / Г.Ц. Дамбаев, В.П. Саганов, Л.Д. Раднаева [и др.] // Бюллетень ВСНЦ СО РАМН. – 2015. – Т.102, №2. – С. 99-102.</mixed-citation><mixed-citation xml:lang="en">Mikrobnyj pejzazh operirovannyh bol’nyh s ogranichennym steril’nym pankreonekrozom v razlichnye periody kompleksnogo lecheniya [Microbial landscape of operated patients with limited sterile pancreatic necrosis during various periods of complex treatment]. Byulleten’ VSNC SO RAMN, 2015, No. 2(102), рр. 99-102.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Мругова Т.М. Серорезистентность и устойчивость к антибиотикам штаммов Escherichia coli, выделенных от пациентов с инфекционно-воспалительными заболеваниями / Т.М. Мругова, В.А. Гриценко, В.А. Агеевец // Проблемы медицинской микологии. – 2020. – Т.22, №3. – С. 108.</mixed-citation><mixed-citation xml:lang="en">Mrugova, T.M. Serorezistentnost’ i ustojchivost’ k antibiotikam shtammov Escherichia coli, vydelennyh ot pacientov s infekcionno-vospalitel’nymi zabolevaniyami [Seroresistance and antibiotic resistance of Escherichia coli strains isolated from patients with infectious and inflammatory diseases]. Problemy medicinskoj mikologii, 2020, No.3(22), рр. 108.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Послеоперационные внутрибрюшные абсцессы в гепатобилиарной хирургии: вопросы выбора адекватного метода хирургического лечения / Ф.И. Махмадов, М.Ф. Джураев, Д.Н. Садуллоев [и др.] // Вестник ИПО в СЗ РТ. – 2022. – №4. – С. 30-39.</mixed-citation><mixed-citation xml:lang="en">Posleoperacionnye vnutribryushnye abscessy v gepatobiliarnoj hirurgii: voprosy vybora adekvatnogo metoda hirurgicheskogo lecheniya [Postoperative intra-abdominal abscesses in hepatobiliary surgery: issues of choosing an adequate method of surgical treatment]. Vestnik IPO v SZ RT, 2022, No. 4, рр. 30-39.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Эффективность применения монооксида азот-содержащего газового потока при миниинвазивном лечении интраабдоминальных абсцессов / С.И. Кубанов, И. В. Суздальцев, А. Г. Бондаренко [и др.] // Вестн. Северо-Кавказ. федерал. ун-та. - 2014. - № 1 (40). - С. 83-85.</mixed-citation><mixed-citation xml:lang="en">Effektivnost’ lecheniya peritonita u eksperimental’nyh zhivotnyh v zavisimosti ot sposoba sanacii bryushnoj polosti [The effectiveness of treatment of peritonitis in experimental animals depending on the method of sanitation of the abdominal cavity]. Medicinskij vestnik Severnogo Kavkaza, 2015, No. 4 (10), рр. 344-348.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Antibiotic sensitivity in correlation to the origin of secondary peritonitis: a single center analysis / R. Grotelüschen, L.M. Heidelmann, M. Lütgehetmann [et all.] // Scientific Reports, 2020, No. 1(10), рр. 1-9.</mixed-citation><mixed-citation xml:lang="en">Antibiotic sensitivity in correlation to the origin of secondary peritonitis: a single center analysis / R. Grotelüschen, L.M. Heidelmann, M. Lütgehetmann [et all.] // Scientific Reports, 2020, No. 1(10), рр. 1-9.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Characteristics and management of pyogenic liver abscess: A European experience / Serraino C. [et all.]. // Medicine (Baltimore), 2018, No. 97(19): e0628. doi: 10.1097/MD.0000000000010628. PMID: 29742700; PMCID: PMC5959441.</mixed-citation><mixed-citation xml:lang="en">Characteristics and management of pyogenic liver abscess: A European experience / Serraino C. [et all.]. // Medicine (Baltimore), 2018, No. 97(19): e0628. doi: 10.1097/MD.0000000000010628. PMID: 29742700; PMCID: PMC5959441.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Clinical effects and prognostic significance of intra-abdominal pressure in secondary peritonitis / D. Mahmutaj, B. Braha, A. Hamza [et all.] // Journal of International Dental and Medical Research, 2021, No. 1(14), рр. 453-460.</mixed-citation><mixed-citation xml:lang="en">Clinical effects and prognostic significance of intra-abdominal pressure in secondary peritonitis / D. Mahmutaj, B. Braha, A. Hamza [et all.] // Journal of International Dental and Medical Research, 2021, No. 1(14), рр. 453-460.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Comparative analysis of percutaneous drainage versus operative drainage of intra-abdominal abscesses in a resourcelimited setting: The tanzanian experience / Ukweh O.N. [et all.] // Annals of global health, 2023, No. 89(1), рр. 1-7. DOI: https://doi.org/10.5334/aogh.4070.</mixed-citation><mixed-citation xml:lang="en">Comparative analysis of percutaneous drainage versus operative drainage of intra-abdominal abscesses in a resourcelimited setting: The tanzanian experience / Ukweh O.N. [et all.] // Annals of global health, 2023, No. 89(1), рр. 1-7. DOI: https://doi.org/10.5334/aogh.4070.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Droniak M.M. Evaluation of the effectiveness of treatment of experimental postoperative peritonitis / M.M. Droniak // Journal of Education, Health and Sport, 2021, No. 11(1), рр. 290-296.</mixed-citation><mixed-citation xml:lang="en">Droniak M.M. Evaluation of the effectiveness of treatment of experimental postoperative peritonitis / M.M. Droniak // Journal of Education, Health and Sport, 2021, No. 11(1), рр. 290-296.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Epidemiology of intra-abdominal infection and sepsis in critically ill patients: «Abses», a multinational observational cohort study and ESICM Trials Group Project / S. Blot, M. Antonelli, K. Arvaniti [et al.] // Intensive care medicine, 2019, No. 12(45), рр. 1703-1717.</mixed-citation><mixed-citation xml:lang="en">Epidemiology of intra-abdominal infection and sepsis in critically ill patients: «Abses», a multinational observational cohort study and ESICM Trials Group Project / S. Blot, M. Antonelli, K. Arvaniti [et al.] // Intensive care medicine, 2019, No. 12(45), рр. 1703-1717.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Microbial findings, sensitivity and outcome in patients with postoperative peritonitis a retrospective cohort study / R. Grotelueschen, M. Luetgehetmann, J. Erbes // International Journal of Surgery, 2019, Vol. 70, рр. 63-69.</mixed-citation><mixed-citation xml:lang="en">Microbial findings, sensitivity and outcome in patients with postoperative peritonitis a retrospective cohort study / R. Grotelueschen, M. Luetgehetmann, J. Erbes // International Journal of Surgery, 2019, Vol. 70, рр. 63-69.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Pyogenic liver abscess: Clinical features and microbiological profiles in tertiary care center / Kumar SK [et all.] // J. Family Med Prim Care, 2020, No. 9(8), рр. 4337-4342.</mixed-citation><mixed-citation xml:lang="en">Pyogenic liver abscess: Clinical features and microbiological profiles in tertiary care center / Kumar SK [et all.] // J. Family Med Prim Care, 2020, No. 9(8), рр. 4337-4342.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Population-Based study of unfavorable prognostic factors associated with pyogenic liver abscess / Bläckberg A [et all.] // Open Forum Infect Dis, 2023, No.10(8), ofad352. doi: 10.1093/ofid/ofad352. PMID: 37547858; PMCID: PMC10400158.</mixed-citation><mixed-citation xml:lang="en">Population-Based study of unfavorable prognostic factors associated with pyogenic liver abscess / Bläckberg A [et all.] // Open Forum Infect Dis, 2023, No.10(8), ofad352. doi: 10.1093/ofid/ofad352. PMID: 37547858; PMCID: PMC10400158.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
