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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">thealth</journal-id><journal-title-group><journal-title xml:lang="ru">Здравоохранение Таджикистана</journal-title><trans-title-group xml:lang="en"><trans-title>Health care of Tajikistan</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0514-2415</issn><publisher><publisher-name>Редакция журнала «Здравоохранение Таджикистана»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52888/0514-2515-2024-362-3-39-44</article-id><article-id custom-type="elpub" pub-id-type="custom">thealth-580</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Влияние тяжёлой преэклампсии в сочетании с дородовым разрывом плодных оболочек на течение раннего неонатального периода</article-title><trans-title-group xml:lang="en"><trans-title>Influence of severe pre-eclampsia in combination with premature rupture of members on the course of the early neonatal period</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каримова</surname><given-names>У. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Karimova</surname><given-names>U. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каримова Умеда Анваровна – ассистент кафедры акушерства и гинекологии №1 ГОУ «ТГМУ имени Абуали ибни Сино».</p><p>Тел.: +992918617785</p></bio><bio xml:lang="en"><p>Umeda A. Karimova - Assistant of the Department of Obstetrics and Gynaecology №1 of the SEI Avicenna Tajik State Medical University’.</p><p>Tel: +992918617785</p></bio><email xlink:type="simple">karimovaumeda555@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Додхоев</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Dodkhoev</surname><given-names>D. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Узакова</surname><given-names>У. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Uzakova</surname><given-names>U. D.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кафедра акушерства и гинекологии №1, ГОУ «ТГМУ имени Абуали ибни Сино»</institution><country>Таджикистан</country></aff><aff xml:lang="en"><institution>Department of Obstetrics and Gynecology No. 1, SEI Avicenna Tajik State Medical University</institution><country>Tajikistan</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Кафедра педиатрии №1, ГОУ «ТГМУ имени Абуали ибни Сино»</institution><country>Таджикистан</country></aff><aff xml:lang="en"><institution>Department of Pediatrics No. 1, SEI Tajik State Medical University named after Abuali ibni Sino</institution><country>Tajikistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>29</day><month>10</month><year>2024</year></pub-date><volume>0</volume><issue>3</issue><fpage>39</fpage><lpage>44</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Каримова У.А., Додхоев Д.С., Узакова У.Д., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Каримова У.А., Додхоев Д.С., Узакова У.Д.</copyright-holder><copyright-holder xml:lang="en">Karimova U.A., Dodkhoev D.S., Uzakova U.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.zdrav.tj/jour/article/view/580">https://www.zdrav.tj/jour/article/view/580</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования. Оценка влияния преэкламспии в сочетании с дородовым разрывом плодных оболочек на состояние новорожденных в раннем неонатальном периоде.</p><p>Материал и методы исследования. Исследование включало 984 матерей и их новорождённых, разделенных на 4 группы: основную группу составили 94 женщины и их новорождённые, беременность которых осложнилась тяжелой преэклампсией в сочетании с дородовым разрывом плодных оболочек; вторую или группу сравнения составили 840 пациенток, разделенных на 2 подгруппы: подгруппу А составили 70 пациенток с тяжелой преэклампсией и их новорождённые; подгруппу Б – 770 пациенток с дородовым разрывом плодных оболочек. Группа контроля состоит из 50 здоровых беременных.</p><p>Результаты исследования и их обсуждение. В основной группе родились 31 (33%); в подгруппе А - 21 (30%); подгруппе Б – 69 (9%) недоношенных детей. Новорождённые с экстремальной недоношенностью родились в основной группе в 3,1 и 5,4 раза чаще, чем в подгруппе А и Б (р=0,013). Доказано, что в основной группе был выше респираторный дистресс синдрома, апноэ и энцефалопатия новорождённых. Гипогликемия диагностирована у новорожденных, родившихся от женщин основной группы в 5,6 раз чаще, чем при изолированном дородовом разрыве плодных оболочек (р&lt;0,001) и в 1,3 раз чаще, чем только при преэклампсии (p&gt;0,05). В Республике Таджикистан неонатальная смертность достигает 56,3%.</p></sec><sec><title>Вывод</title><p>Вывод. Существенным потенциалом снижения ранней неонатальной заболеваемости и смертности у женщин с преэклампсией и ДРПО является перенаправление и родоразрешение в учреждениях третьего уровня.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To assess the effect of preeclampsia in combination with premature rupture of membranes (PROM) on the condition of newborns in the early neonatal period.</p></sec><sec><title>Materials and Methods</title><p>Materials and Methods. The study included 984 mothers and their newborns, divided into four groups. The main group comprised 94 women whose pregnancies were complicated by severe preeclampsia and PROM. The comparison group consisted of 840 patients, further divided into two subgroups: subgroup A included 70 patients with severe preeclampsia, and subgroup B included 770 patients with PROM. The control group comprised 50 healthy pregnant women.</p></sec><sec><title>Results and Discussion</title><p>Results and Discussion. In the main group, 31 (33%) newborns were premature; in subgroup A, 21 (30%); and in subgroup B, 69 (9%). Newborns with extreme prematurity were born in the main group 3.1 and 5.4 times more often than in subgroups A and B, respectively (p = 0.013). It was found that the main group had a higher incidence of respiratory distress syndrome, apnea, and neonatal encephalopathy. Hypoglycemia was diagnosed in the main group 5.6 times more frequently than in cases of isolated PROM (p &lt; 0.001) and 1.3 times more frequently than with preeclampsia alone (p &gt; 0.05). In the Republic of Tajikistan, neonatal mortality reaches 56.3%.</p></sec><sec><title>Conclusion</title><p>Conclusion. Reducing early neonatal morbidity and mortality in women with preeclampsia and PROM is possible through referral and delivery in tertiary care facilities.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>тяжёлая преэклампсия</kwd><kwd>дородовый разрыв плодных оболочек</kwd><kwd>неонатальный период</kwd></kwd-group><kwd-group xml:lang="en"><kwd>severe preeclampsia</kwd><kwd>premature rupture of membranes</kwd><kwd>neonatal period</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Икромов Т.Ш. 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