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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">thealth</journal-id><journal-title-group><journal-title xml:lang="ru">Здравоохранение Таджикистана</journal-title><trans-title-group xml:lang="en"><trans-title>Health care of Tajikistan</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0514-2415</issn><publisher><publisher-name>Редакция журнала «Здравоохранение Таджикистана»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52888/0514-2515-2025-364-1-35-41</article-id><article-id custom-type="elpub" pub-id-type="custom">thealth-623</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Отличительные особенности структурно-функционального ремоделирования левых отделов сердца и сосудистой патологии в рамках ревматоидного васкулита у больных ревматоидным артритом в зависимости от наличия системных проявлений заболевания</article-title><trans-title-group xml:lang="en"><trans-title>Vascular pathology and morphofunctional remodeling of the left heart in rheumatoid arthritis: impact of systemic manifestations and rheumatoid vasculitis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зубайдов</surname><given-names>Р. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zubaidov</surname><given-names>R. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зубайдов Рустам Нигматович – к.м.н., доцент, заведующий кафедрой</p><p>Тел.: +992992517270</p></bio><bio xml:lang="en"><p>Zubaydov Rustam Nigmatovich - Candidate of medical sciences, associate professor, head</p><p>Tel.: +992992517270</p></bio><email xlink:type="simple">qosimzoda.96@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каримова</surname><given-names>Г. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Karimova</surname><given-names>G. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Боев</surname><given-names>С. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Boev</surname><given-names>S. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джаборов</surname><given-names>М. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Jaborov</surname><given-names>M. Q.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Саидов</surname><given-names>Ё. У.</given-names></name><name name-style="western" xml:lang="en"><surname>Saidov</surname><given-names>Y. U.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГОУ «ТГМУ им. Абуали ибни Сино»</institution><country>Таджикистан</country></aff><aff xml:lang="en"><institution>SEI Avicenna Tajik State Medical University</institution><country>Tajikistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>07</day><month>04</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>35</fpage><lpage>41</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Зубайдов Р.Н., Каримова Г.Н., Боев С.М., Джаборов М.К., Саидов Ё.У., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Зубайдов Р.Н., Каримова Г.Н., Боев С.М., Джаборов М.К., Саидов Ё.У.</copyright-holder><copyright-holder xml:lang="en">Zubaidov R.N., Karimova G.N., Boev S.N., Jaborov M.Q., Saidov Y.U.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.zdrav.tj/jour/article/view/623">https://www.zdrav.tj/jour/article/view/623</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования. Изучить и определить отличительные особенности структурно-геометрических перестроек левых отделов сердца.</p><p>Материал и методы исследования. В исследование было включено 102 пациента с достоверным диагнозом ревматоидный артрит, которые находились на стационарном лечении в кардиоревматологическое отделение. Пациенты были разделены на две группы по степени активности заболевания. Контрольную группу составили 40 здоровых человек. Оценка активности проводилась с использованием индекса DAS28. Всем больным было проведено эхокардиографическое исследование, а также морфологическое исследование сосудов.</p><p>Результаты исследования и их обсуждение. Значительные изменения морфофункциональных параметров левого сердца, такие как увеличение конечного диастолического и систолического объема левого желудочка, гипертрофия миокарда и диастолическая дисфункция, наблюдаются у пациентов с ревматоидным артритом, особенно при системных проявлениях. Установлена корреляция между активностью воспаления и показателями сердечной геометрии. Выявлены ассоциации между кожными проявлениями васкулита и сосудистыми патологиями.</p></sec><sec><title>Заключение</title><p>Заключение. Гипертрофия левого желудочка и его диастолическая дисфункция являются ранними маркерами сердечно-сосудистых осложнений при ревматоидном артрите, особенно при сочетании с ИБС. Прогрессирование воспалительного процесса способствует развитию гипертрофии, а кожные проявления ревматоидного васкулита могут отражать общие патогенетические механизмы сосудистых нарушений.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To study and determine the characteristics of structural-geometric remodeling of the left heart chambers.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study included 102 patients with a confirmed diagnosis of rheumatoid arthritis who were hospitalized in the cardiorheumatology department. Patients were divided into two groups according to the degree of disease activity. The control group consisted of 40 healthy subjects. Disease activity was assessed using the DAS28 index. All patients underwent echocardiography and morphologic evaluation of the blood vessels.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. Significant changes in morphofunctional parameters of the left heart were observed in patients with rheumatoid arthritis, especially in those with systemic manifestations. These changes included increased left ventricular end-diastolic and end-systolic volumes, myocardial hypertrophy, and diastolic dysfunction. An association was found between inflammatory activity and cardiac geometry parameters. In addition, associations were found between cutaneous manifestations of vasculitis and vascular pathologies.</p></sec><sec><title>Conclusion</title><p>Conclusion. Left ventricular hypertrophy and diastolic dysfunction serve as early markers of cardiovascular complications in rheumatoid arthritis, especially in combination with ischemic heart disease. The progression of the inflammatory process contributes to the development of hypertrophy, and cutaneous manifestations of rheumatoid vasculitis may reflect common pathogenetic mechanisms underlying vascular disorders.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>Ревматоидный артрит</kwd><kwd>сердечно-сосудистые осложнения</kwd><kwd>гипертрофия левого желудочка</kwd><kwd>диастолическая дисфункция</kwd><kwd>васкулит</kwd><kwd>эхокардиография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rheumatoid arthritis</kwd><kwd>cardiovascular complications</kwd><kwd>left ventricular hypertrophy</kwd><kwd>diastolic dysfunction</kwd><kwd>vasculitis</kwd><kwd>echocardiography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Герасимова Е.В. Сердечно-сосудистые заболевания у больных ревматоидным артритом на фоне длительной терапии метотрексатом / Е.В. Герасимова, Т.В. 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