thealthЗдравоохранение ТаджикистанаHealth care of Tajikistan0514-2415Редакция журнала «Здравоохранение Таджикистана»10.52888/0514-2515-2025-364-1-115-123thealth-635Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWПротивовирусные и антибактериальные свойства растений рода Ferula L.Antiviral and antibacterial properties of plants of the genus Ferula L.СаторовС.SatorovS.МавлоназароваС. Н.MavlonazarovaS. N.

Мавлоназарова Сулхия Ноёбшоевна – аспирант

Тел.: +992559993188

Mavlonazarova Sulkhiya Noyobshoevna - postgraduate student

Tel.: +992559993188

smavlon88@mail.ruЮсуфиС. Дж.YusufiS. J.НОУ «Медико-социальный институт Таджикистана»ТаджикистанNEI Medical and Social Institute of TajikistanTajikistanГОУ «ТГМУ им. Абуали ибни Сино»ТаджикистанSEI Avicenna Tajik State Medical UniversityTajikistan20250804202501115123Copyright © Саторов С., Мавлоназарова С.Н., Юсуфи С.Д., 20252025Саторов С., Мавлоназарова С.Н., Юсуфи С.Д.Satorov S., Mavlonazarova S.N., Yusufi S.J.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.zdrav.tj/jour/article/view/635

В статье приводится обзор литературы противовирусных и антибактериальных свойств видов Ferula L. Экстракты и камедь, полученные из различных видов данного рода растений, с древних времен используются в традиционной медицине и продолжают применяться на данном этапе. Во всех соответствующих базах данных был проведен поиск по терминам «Ферула», «противовирусный», «противогриппозный», «противогрибковый» без ограничений до 01 июня 2024 года. Информация была собрана с помощью электронного поиска, используя Science Direct, Web of Science, Scopus, PubMed, EBSCO до 01.06.2024 года. Ключевые слова также вводились в популярные поисковые системы, включая Google и Google Scholar. Данные научной литературы позволяют резюмировать, что многие представители этого вида растений обладают достаточно выраженным противовирусным, антибактериальным и противогрибковыми свойствами. Однако в научной литературе нет информации о биологической активности видов Ferula L., произрастающих в Таджикистане.

This article presents a literature review on the antiviral and antibacterial properties of Ferula L. species. Extracts and gums from different species of this plant genus have been used in traditional medicine since ancient times and are still used today. All relevant databases including Science Direct, Web of Science, Scopus, PubMed, EBSCO were searched without restriction using the terms “Ferula”, “antiviral”, “anti-influenza”, “anti-fungal” up to 01 June 2024. Keywords were also entered into popular search engines such as Google and Google Scholar. According to the literature, it can be concluded that many representatives of this plant species have strong antiviral, antibacterial and antifungal properties. However, there is no information in the literature on the biological activity of Ferula L. species growing in Tajikistan.

Ferula Lпротивовирусные свойстваантибактериальные свойствамикоорганизмыFerula L.antiviral propertiesantibacterial propertiesmycoorganismsReferencesСаторов С. Вирусингибирующий эффект растения вида FerulaKuhistanicaKorovin, произрастающего в высокогорных условиях Республики Таджикистан / С.Н. Мавлоназарова, С.Д. Юсуфи // Здравоохранение Таджикистана. – 2023. – №2. - С. 100-105Satorov S. Virusingibiruyushchiy effekt rasteniya vida FerulaKuhistanicaKorovin, proizrastayushchego v vysokogornykh usloviyakh Respubliki Tadzhikistan [Virusinhibitory effect of Ferula Kuhistanica Korovin species growing in high mountainous conditions of the Republic of Tajikistan]. Zdravookhranenie Tadzhikistana – Healthcare of Tajikistan, 2023, No. 2, pp. 100-105Саторов С. Исследование антибактериальной активности экстрактов различных видов рода Allium, произрастающих в Таджикистане / Ф.Д. Мирзоева // Вестник Авиценны – 2021. –Т 23, №2. - С. 216-34.Satorov S. Issledovanie antibakterialnoy aktivnosti ekstraktov razlichnykh vidov roda Allium, proizrastayushchikh v Tadzhikistane [Study of antibacterial activity of extracts of different species of Allium genus growing in Tajikistan]. Vestnik Avitsenny – Avicenna Bulletin, 2021, Vol. 23, No. 2, pp. 216-34.Саторов С. Содержание общих полифенолов и антиоксидантная активность растений рода Allium и их корреляция с антибактериальной и противогрибковой активностью / Ф.Д. Мирзоева // Здравоохранение Таджикистана». – 2021. – №2 (349). – С. 85-97.Satorov S.Soderzhanie obshchikh polifenolov i antioksidantnaya aktivnost rasteniy roda Allium i ikh korrelyatsiya s antibakterialnoy i protivogribkovoy aktivnostyu [Content of total polyphenols and antioxidant activity of plants of Allium genus and their correlation with antibacterial and antifungal activity]. Zdravookhranenie Tadzhikistana – Healthcare of Tajikistan, 2021, No. 2 (349), pp. 85-97.Abascal K. Herbal treatments for pandemic influenza. Learning from the eclectics’ experience Alternative & Complementary Therapies, 2006, Vol. 12, No. 5, pp. 214–221.Abascal K. Herbal treatments for pandemic influenza. Learning from the eclectics’ experience Alternative & Complementary Therapies, 2006, Vol. 12, No. 5, pp. 214–221.Ahmadi Koulaei S. Chemical composition and biological activity of Ferulaaucheri essential oil. Research Journal of Pharmacognosy, 2020, Vol. 7, No. 2, pp. 21-31.Ahmadi Koulaei S. Chemical composition and biological activity of Ferulaaucheri essential oil. Research Journal of Pharmacognosy, 2020, Vol. 7, No. 2, pp. 21-31.Baldemir A. Antimicrobial activity of Ferula halophila Peflmen. FABAD Journal of Pharmaceutical Sciences, 2006, No. 31, pp. 57-61.Baldemir A. Antimicrobial activity of Ferula halophila Peflmen. FABAD Journal of Pharmaceutical Sciences, 2006, No. 31, pp. 57-61.Daneshkazemi A. et al. Antimicrobial Activity of the essential oil obtained from the seed and oleo-gum-resin of Ferula AssaFoetida against oral pathogens. Front Dent, 2019, Vol. 16, No. 2, pp. 113-120.Daneshkazemi A. et al. Antimicrobial Activity of the essential oil obtained from the seed and oleo-gum-resin of Ferula AssaFoetida against oral pathogens. Front Dent, 2019, Vol. 16, No. 2, pp. 113-120.Dastan D. Disesquiterpene and sesquiterpene coumarins from Ferulapseudalliacea, and determination of their absolute configurations. Phytochemistry, 2012, No. 78, pp. 170-78.Dastan D. Disesquiterpene and sesquiterpene coumarins from Ferulapseudalliacea, and determination of their absolute configurations. Phytochemistry, 2012, No. 78, pp. 170-78.Dastan D. Chemical composition and bioactivities of essential oils from different plant parts of Ferula pseudalliacea Rech.f. as an endemic plant from Iran. Natural Product Research, 2022, Vol. 36, No. 5, pp. 1311–1316.Dastan D. Chemical composition and bioactivities of essential oils from different plant parts of Ferula pseudalliacea Rech.f. as an endemic plant from Iran. Natural Product Research, 2022, Vol. 36, No. 5, pp. 1311–1316.Dissanayake, K.G.C. Medicinal importance of Ferula asafetida oligo- gum resins against infective diseases. Research Journal of Medicinal Plant, 2020, No. 8, pp. 135-139.Dissanayake, K.G.C. Medicinal importance of Ferula asafetida oligo- gum resins against infective diseases. Research Journal of Medicinal Plant, 2020, No. 8, pp. 135-139.Ed-DahmaniI, Evaluation of Polyphenolic Content, Antioxidant and Antimicrobial Activities, and Toxicity Study of Ferula communis L. Tropical Journal of Natural Product Research, 2024, Vol. 8, No. 2, pp. 6423-6432.Ed-DahmaniI, Evaluation of Polyphenolic Content, Antioxidant and Antimicrobial Activities, and Toxicity Study of Ferula communis L. Tropical Journal of Natural Product Research, 2024, Vol. 8, No. 2, pp. 6423-6432.Fani M.M. An in Vitro Study on the Antibacterial Effect of FerulaAssa-Foetida L. and Quercus Infectoria Olivier Extracts on Streptococcus Mutans and Streptococcus Sanguis. Avicenna Journal of Dental Research, 2015, Vol. 7, No. 1.Fani M.M. An in Vitro Study on the Antibacterial Effect of FerulaAssa-Foetida L. and Quercus Infectoria Olivier Extracts on Streptococcus Mutans and Streptococcus Sanguis. Avicenna Journal of Dental Research, 2015, Vol. 7, No. 1.Fossum E. Antigenic drift and immunity gap explain reduction in protective responses against influenza A(H1N1) pdm09 and A(H3N2) viruses during the COVID-19 pandemic: a cross-sectional study of human sera collected in 2019, 2021, 2022, and 2023. Virology Journal, 2023, No. 21 (57).Fossum E. Antigenic drift and immunity gap explain reduction in protective responses against influenza A(H1N1) pdm09 and A(H3N2) viruses during the COVID-19 pandemic: a cross-sectional study of human sera collected in 2019, 2021, 2022, and 2023. Virology Journal, 2023, No. 21 (57).Galal A.M. Daucane sesquiterpenes from Ferulahermonis. Journal of Natural Products, 2001, Vol. 64, No. 3, pp. 399-400.Galal A.M. Daucane sesquiterpenes from Ferulahermonis. Journal of Natural Products, 2001, Vol. 64, No. 3, pp. 399-400.Ghannadi A., Fattahian K., Shokoohinia Y. Anti-Viral Evaluation of Sesquiterpene Coumarins from Ferula Assa-Foetida against HSV-1. Iranian Journal of Pharmaceutical Research, 2014, No. 13 (2), pp. 523-530.Gao T.T., Yu F.H., Tan Y. Study on Antimicrobial Activity in vitro of Extracts from Three Species of Ferula Root. Beifang Yuany, 2013, No. 24, pp. 156–158.Gunther R.T. The Greek Herbal of Dioscorides. London, Hafner Publ., 1968.Ghannadi A., Fattahian K., Shokoohinia Y. Anti-Viral Evaluation of Sesquiterpene Coumarins from Ferula Assa-Foetida against HSV-1. Iranian Journal of Pharmaceutical Research, 2014, No. 13 (2), pp. 523-530.Kahraman C., Topcu G., Bedir E. Phytochemical screening and evaluation of the antimicrobial and antioxidant activities of Ferula caspica M. Bieb. extracts. Saudi Pharmaceutical Journal, 2019, No. 27 (4), pp. 525-531.Gunther R.T. The Greek Herbal of Dioscorides. London, Hafner Publ., 1968.Kavaz D., Faraj R.E. Investigation of composition, antioxidant, antimicrobial and cytotoxic characteristics from Juniperussabina and Ferulacommunis extracts. Science Reports, 2023, No. 13, pp. 7193.Kahraman C., Topcu G., Bedir E. Phytochemical screening and evaluation of the antimicrobial and antioxidant activities of Ferula caspica M. Bieb. extracts. Saudi Pharmaceutical Journal, 2019, No. 27 (4), pp. 525-531.Korovin E.P. Genus Ferula L. Flora of the USSR. 1951, pp. 62-142.Kavaz D., Faraj R.E. Investigation of composition, antioxidant, antimicrobial and cytotoxic characteristics from Juniperussabina and Ferulacommunis extracts. Science Reports, 2023, No. 13, pp. 7193.Kurkcuoglu M., Iscan G., Tosun F., Miski M. Biological activity and chemical composition of the essential oil from the fruits of Ferula halophila Peşmen. ACTA Pharmaceutica Sciencia, 2023, Vol. 61, No. 1.Korovin E.P. Genus Ferula L. Flora of the USSR. 1951, pp. 62-142.Lee C.L., Chiang L.C., Cheng L.H. Influenza A (H1N1) antiviral and cytotoxic agents from Ferulaassa-foetida. Journal of Natural Products, 2009, No. 72 (9), pp. 1568-72.Kurkcuoglu M., Iscan G., Tosun F., Miski M. Biological activity and chemical composition of the essential oil from the fruits of Ferula halophila Peşmen. ACTA Pharmaceutica Sciencia, 2023, Vol. 61, No. 1.Liu T., Osman K., Kaatz G.G., Simon M. Q. Antibacterial Sesquiterpenoid Derivatives from Ferulaferulaeoides. Planta medica, 2013, No. 79, pp. 10.Lee C.L., Chiang L.C., Cheng L.H. Influenza A (H1N1) antiviral and cytotoxic agents from Ferulaassa-foetida. Journal of Natural Products, 2009, No. 72 (9), pp. 1568-72.Mahdizadeh S., Khaleghi G.M., Gorji A. Avicenna’s Canon of Medicine: a review of analgesics and anti-inflammatory substances. Avicenna Journal of Phytomedicine, 2015, Vol. 5 (3), pp. 182-202.Liu T., Osman K., Kaatz G.G., Simon M. Q. Antibacterial Sesquiterpenoid Derivatives from Ferulaferulaeoides. Planta medica, 2013, No. 79, pp. 10.Mareshah A., Schroeder S., Goelz L. Antimicrobial activity of the volatile substances from essential oils. BMC Complementary Medicine and Therapies, 2021, No. 21, pp. 11-14.Mahdizadeh S., Khaleghi G.M., Gorji A. Avicenna’s Canon of Medicine: a review of analgesics and anti-inflammatory substances. Avicenna Journal of Phytomedicine, 2015, Vol. 5 (3), pp. 182-202.Mashael W. Alruways. Antimicrobial effects of Ferula species- an herbal tactic for management of infectious diseases. Journal of King Saud University. Science, 2023, pp. 102806Mareshah A., Schroeder S., Goelz L. Antimicrobial activity of the volatile substances from essential oils. BMC Complementary Medicine and Therapies, 2021, No. 21, pp. 11-14.Moradi M., Karimi A., lorigooini Z. In vitro anti influenza virus activity, antioxidant potential and total phenolic content of twelve Iranian medicinal plants. Marmara Pharmaceutical Journal, No. 21(4), pp. 843-851.Mashael W. Alruways. Antimicrobial effects of Ferula species- an herbal tactic for management of infectious diseases. Journal of King Saud University. Science, 2023, pp. 102806Nunn J.F. Ancient Egyptian medicine. Transactions of the Medical Society of London, 1996, No. 113, pp. 57-68.Moradi M., Karimi A., lorigooini Z. In vitro anti influenza virus activity, antioxidant potential and total phenolic content of twelve Iranian medicinal plants. Marmara Pharmaceutical Journal, No. 21(4), pp. 843-851.Pavlović I., Petrović S., Radenković M., Milenković M., et al. Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil. Food Chemistry, 2012, Vol. 130, No. 2, pp. 310-315.Nunn J.F. Ancient Egyptian medicine. Transactions of the Medical Society of London, 1996, No. 113, pp. 57-68.Richa B., Rani R., Dang A.S. Antibacterial activity of Ferulaasafoetida: a comparison of red and white type. Journal of Applied Biology and Biotechnology, 2015, No. 3, pp. 0-2.Pavlović I., Petrović S., Radenković M., Milenković M., et al. Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil. Food Chemistry, 2012, Vol. 130, No. 2, pp. 310-315.Safi R., El-Sabban M., Najjar F. Ferula hermonis: A Review of Current Use and Pharmacological Studies of its Sesquiterpene Ester Ferutinin. Curr Drug Targets, 2020, No. 21 (5), pp. 499-508.Richa B., Rani R., Dang A.S. Antibacterial activity of Ferulaasafoetida: a comparison of red and white type. Journal of Applied Biology and Biotechnology, 2015, No. 3, pp. 0-2.Satorov S., Mirzoeva F.D, Satorov Sh.S. Comparative characteristic of antibacterial activity of plants growing in the central part of the Republic of Tajikistan. Avicenna Bulletin, 2019, No. 4 (21), pp. 643-653.Safi R., El-Sabban M., Najjar F. Ferula hermonis: A Review of Current Use and Pharmacological Studies of its Sesquiterpene Ester Ferutinin. Curr Drug Targets, 2020, No. 21 (5), pp. 499-508.Sharopov F., Braun M.S., Gulmurodov I., Khalifaev D., Isupov S., Wink M. Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Essential Oils of Selected Aromatic Plants from Tajikistan. Foods, 2015, No. 4 (4), pp. 645-653.Satorov S., Mirzoeva F.D, Satorov Sh.S. Comparative characteristic of antibacterial activity of plants growing in the central part of the Republic of Tajikistan. Avicenna Bulletin, 2019, No. 4 (21), pp. 643-653.Tosun F., Göger F. Activities of the Fruit Essential Oil, Fruit, and Root Extracts of Feruladrudeana Korovin, the Putative Anatolian Ecotype of the Silphion Plant. Plants, 2023, No. 12, pp. 830.Sharopov F., Braun M.S., Gulmurodov I., Khalifaev D., Isupov S., Wink M. Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Essential Oils of Selected Aromatic Plants from Tajikistan. Foods, 2015, No. 4 (4), pp. 645-653.Tuncay H.O., Akalın E., Doğru‐Koca A., Eruçar F.M., Miski M. Two New Ferula (Apiaceae) Species from Central Anatolia: Ferula turcica and Ferula latialata. Horticulturae, 2023, No. 9, pp. 144.Tosun F., Göger F. Activities of the Fruit Essential Oil, Fruit, and Root Extracts of Feruladrudeana Korovin, the Putative Anatolian Ecotype of the Silphion Plant. Plants, 2023, No. 12, pp. 830.Xu H., Dickschat, J.S. Germacrene B—A Central Intermediate in Sesquiterpene Biosynthesis. Beilstein Journal of Organic Chemistry, 2023, No. 19, pp. 186–203.Tuncay H.O., Akalın E., Doğru‐Koca A., Eruçar F.M., Miski M. Two New Ferula (Apiaceae) Species from Central Anatolia: Ferula turcica and Ferula latialata. Horticulturae, 2023, No. 9, pp. 144.Zellagui A., Gherraf N., Hegazy M., Akkal S., Rhouati S., Dendougui H. Phytochemical investigation and antimicrobial activity of crude extract of the roots of Ferula vesceritensis. Chemistry of Natural Compounds, 2012, No. 48, pp. 891–892.Xu H., Dickschat, J.S. Germacrene B—A Central Intermediate in Sesquiterpene Biosynthesis. Beilstein Journal of Organic Chemistry, 2023, No. 19, pp. 186–203.Zellagui A., Gherraf N., Rhouati S. Chemical composition and antibacterial activity of the essential oils of Ferulavesceritensis Coss et Dur. leaves, endemic in Algeria. Organic and Medicinal Chemistry Letters, 2012, No. 2, pp. 31.Zellagui A., Gherraf N., Hegazy M., Akkal S., Rhouati S., Dendougui H. Phytochemical investigation and antimicrobial activity of crude extract of the roots of Ferula vesceritensis. Chemistry of Natural Compounds, 2012, No. 48, pp. 891–892.Zomorodian K., Saharkhiz J., Pakshir K. The composition, antibiofilm and antimicrobial activities of essential oil of Ferula assafoetida oleo-gum-resin. Biocatalysis and Agricultural Biotechnology, 2018, No. 14, pp. 300-304.Zellagui A., Gherraf N., Rhouati S. Chemical composition and antibacterial activity of the essential oils of Ferulavesceritensis Coss et Dur. leaves, endemic in Algeria. Organic and Medicinal Chemistry Letters, 2012, No. 2, pp. 31.Zomorodian K., Saharkhiz J., Pakshir K. The composition, antibiofilm and antimicrobial activities of essential oil of Ferula assafoetida oleo-gum-resin. Biocatalysis and Agricultural Biotechnology, 2018, No. 14, pp. 300-304.Zomorodian K., Saharkhiz J., Pakshir K. The composition, antibiofilm and antimicrobial activities of essential oil of Ferula assafoetida oleo-gum-resin. Biocatalysis and Agricultural Biotechnology, 2018, No. 14, pp. 300-304.

The authors declare that there are no conflicts of interest present.