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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">thealth</journal-id><journal-title-group><journal-title xml:lang="ru">Здравоохранение Таджикистана</journal-title><trans-title-group xml:lang="en"><trans-title>Health care of Tajikistan</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0514-2415</issn><publisher><publisher-name>Редакция журнала «Здравоохранение Таджикистана»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52888/0514-2515-2025-366-3-67-76</article-id><article-id custom-type="elpub" pub-id-type="custom">thealth-675</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Состояние кровотока в сосудах семенного канатика у мужчин с паховой грыжей: клинико-ультразвуковое исследование и коррекция тестикулярной дисфункции</article-title><trans-title-group xml:lang="en"><trans-title>The state of blood flow in the spermatic cord vessel in men with inguinal hernia: a clinical and ultrasonic study and correction of testicular dysfunction</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6216-2468</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сафарзода</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Safarzoda</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сафарзода Имрон Сафар - соискатель кафедры общей хирургии №2 </p><p>г. Душанбе, Тел.: +992918488181 </p></bio><bio xml:lang="en"><p>Safarzoda Imron Safar - Applicant Department of General Surgery No. 2 </p><p>Dushanbe, Tel.: +992918488181 </p></bio><email xlink:type="simple">imron_1991_06@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГОУ “Таджикский государственный медицинский университет имени Абуали ибни Сино”</institution><country>Таджикистан</country></aff><aff xml:lang="en"><institution>SEI Avicenna Tajik State Medical University</institution><country>Tajikistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>14</day><month>10</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>67</fpage><lpage>76</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сафарзода И.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Сафарзода И.С.</copyright-holder><copyright-holder xml:lang="en">Safarzoda I.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.zdrav.tj/jour/article/view/675">https://www.zdrav.tj/jour/article/view/675</self-uri><abstract><p>Цель: оценить тестикулярную функцию и кровоток в сосудах семенного канатика и яичка у мужчин с паховой грыжей (ПГ) до и после операции.Материал и методы: в проспективное исследование включены 60 мужчин с односторонней ПГ и 30 здоровых добровольцев. Всем пациентам и контрольной группе проводилось цветное дуплексное сканирование сосудов семенного канатика и яичек с использованием модифицированной методики И.И. Успенского. Оценивались пиковая систолическая скорость (PSV), средняя скорость (Mean), индекс резистентности (RI) и ретроградный венозный кровоток (V ven). Дополнительно у подгруппы пациентов (n=40) и контролей (n=20) определялись уровни половых гормонов, а у 35 пациентов - показатели спермограммы. Изучены маркеры оксидативного эндотоксикоза (МДА, ДК) и гипоксии (лактат) в сыворотке крови и венозной крови яичка.Результаты: средняя скорость артериального кровотока на поражённой стороне у пациентов с ПГ была статистически значимо ниже (11,28 [10,2–12,5] см/с), чем на контралатеральной стороне (14,08 [12,3–15,8] см/с; p &lt;0,001) и у здоровых добровольцев (15,22 [14,5–16,3] см/с; p &lt;0,001). Выявлена прямая зависимость между размером грыжи и выраженностью снижения кровотока, а также между длительностью грыженосительства и степенью нарушения. Показатели спермограммы и уровни тестостерона были снижены у пациентов с ПГ, особенно при длительном грыженосительстве и больших размерах грыжи. Обнаружено повышение маркеров оксидативного стресса и гипоксии в венозной крови яичка. Послеоперационный анализ показал улучшение показателей кровотока и тестикулярной функции, особенно при применении лапароскопических и комбинированных методов герниопластики.Выводы: паховая грыжа у мужчин репродуктивного возраста нарушает кровоток в сосудах семенного канатика и паренхиме яичка, вызывая снижение сперматогенеза и тестостерона; выраженность изменений коррелирует с размером и давностью грыжи. Основой дисфункции служат ишемия, гипоксия и оксидативный стресс. Атравматичная лапароскопическая герниопластика с интраоперационным контролем перфузии, дополненная алгоритмом выбора метода операции и схемой профилактики послеоперационной тестикулярной дисфункции, достоверно восстанавливает кровоснабжение и сохраняет репродуктивный потенциал.</p></abstract><trans-abstract xml:lang="en"><p>Objective: to evaluate testicular function and blood flow in the spermatic cord vessels and testicle in men with inguinal hernia (IH) before and after surgery.Materials and methods. This prospective study included 60 men with unilateral IH and 30 healthy volunteers. All participants underwent color duplex ultrasonography of the spermatic cord and testicular vessels using a modified technique by I.I. Uspensky. The following parameters were measured: peak systolic velocity (PSV), mean flow velocity (Mean), resistance index (RI), and retrograde venous flow (V ven). In a subgroup of patients (n = 40) and controls (n = 20), circulating sex hormone levels were measured, and semen analysis was performed in 35 patients. Markers of oxidative endotoxemia (MDA, DC) and a marker of hypoxia (lactate) were measured in both serum and testicular venous blood from.Results. The mean arterial flow velocity on the affected side was significantly lower (11.28 [10.2–12.5] cm/s) than on the contralateral side (14.08 [12.3–15.8] cm/s; p &lt; 0.001) and in healthy volunteers (15.22 [14.5–16.3] cm/s; p &lt; 0.001). A direct correlation was found between hernia size and the degree of blood flow reduction, as well as between the duration of hernia presence and the degree of vascular impairment. Semen parameters and serum testosterone levels decreased in patients with inguinal hernias, especially those with longer duration and larger defects. Markers of oxidative stress and hypoxia were elevated in testicular venous blood. Postoperative follow-up showed improvement in testicular perfusion and function, which was most pronounced after laparoscopic or hybrid hernia repair.Conclusions. An inguinal hernia in men of reproductive age disrupts blood flow in the spermatic cord and testicular parenchyma vessels, which decreases spermatogenesis and testosterone production. The severity of the changes correlates with the size and duration of the hernia. The underlying causes of this dysfunction are ischemia, hypoxia, and oxidative stress. Atraumatic laparoscopic hernioplasty with intraoperative perfusion control, supplemented by an algorithm for selecting the surgical method and a plan for preventing postoperative testicular dysfunction, reliably restores blood flow and preserves reproductive potential.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>паховая грыжа</kwd><kwd>тестикулярная дисфункция</kwd><kwd>кровоток семенного канатика</kwd><kwd>дуплексное сканирование</kwd><kwd>мужское бесплодие</kwd><kwd>герниопластика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>inguinal hernia</kwd><kwd>testicular dysfunction</kwd><kwd>spermatic cord blood flow</kwd><kwd>duplex ultrasonography</kwd><kwd>male infertility</kwd><kwd>hernioplasty</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sapiyeva ST, Abatov NT, Aliyakparov MT, Badyrov RM, Yoshihiro N, Brizitskaya LV, et al. Non-mesh inguinal hernia repair: review. Asian J Surg. 2024;47(11):4669-4673. DOI: 10.1016/j.asjsur.2024.06.055.</mixed-citation><mixed-citation xml:lang="en">Sapiyeva ST, Abatov NT, Aliyakparov MT, Badyrov RM, Yoshihiro N, Brizitskaya LV, et al. Non-mesh inguinal hernia repair: review. Asian J Surg. 2024;47(11):4669-4673. DOI: 10.1016/j.asjsur.2024.06.055.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Aiolfi A, Cavalli M, Del Ferraro S, Manfredini L, Lombardo F, Bonitta G, et al. Total extraperitoneal (TEP) versus laparoscopic transabdominal preperitoneal (TAPP) hernioplasty: systematic review and trial sequential analysis of randomized controlled trials. Hernia. 2021;25(5):1147-1157. DOI: 10.1007/s10029-021-02407-7.</mixed-citation><mixed-citation xml:lang="en">Aiolfi A, Cavalli M, Del Ferraro S, Manfredini L, Lombardo F, Bonitta G, et al. Total extraperitoneal (TEP) versus laparoscopic transabdominal preperitoneal (TAPP) hernioplasty: systematic review and trial sequential analysis of randomized controlled trials. Hernia. 2021;25(5):1147-1157. DOI: 10.1007/s10029-021-02407-7.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Протасов А.В., Кульченко Н.Г., Виноградов И.В. Ассоциация ненатяжной паховой герниопластики и патоспермии у фертильных мужчин. Хирургия. Журнал им. Н. И. Пирогова. 2020;(10):44-48. DOI: 10.17116/hirurgia202010144.</mixed-citation><mixed-citation xml:lang="en">Protasov A.V., Kul’chenko N.G., Vinogradov I.V. Association of tension-free inguinal hernioplasty with pathospermia in fertile men. Khirurgiya. Journal named after N. I. Pirogov. 2020;(10):44-48. (In Russ.). DOI: 10.17116/hirurgia202010144.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ranga H.R., Mishra V., Vidit V., Griwan M., Arora B.K. Study of alteration in testicular perfusion after Lichtenstein hernia repair. Int Surg J. 2024;11(2):215- 221. DOI: 10.18203/2349-2902.isj20240172.</mixed-citation><mixed-citation xml:lang="en">Ranga H.R., Mishra V., Vidit V., Griwan M., Arora B.K. Study of alteration in testicular perfusion after Lichtenstein hernia repair. Int Surg J. 2024;11(2):215- 221. DOI: 10.18203/2349-2902.isj20240172.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Eurlings R., Wijnen R.M., Hirdes J.J., van den Broek W.T., van Kuijk S.M.J. Testicular vascularization after pediatric inguinal hernia repair: a systematic review and meta-analysis. Children. 2024;11(4):409. DOI: 10.3390/children11040409.</mixed-citation><mixed-citation xml:lang="en">Eurlings R., Wijnen R.M., Hirdes J.J., van den Broek W.T., van Kuijk S.M.J. Testicular vascularization after pediatric inguinal hernia repair: a systematic review and meta-analysis. Children. 2024;11(4):409. DOI: 10.3390/children11040409.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Štula I., Družijanić N., Sapunar A., Perko Z., Bošnjak N., Kraljević D. Antisperm antibodies and testicular blood flow after inguinal hernia mesh repair. Surg Endosc. 2014;28(12):3413-20. DOI: 10.1007/s00464-014-3614-7.</mixed-citation><mixed-citation xml:lang="en">Štula I., Družijanić N., Sapunar A., Perko Z., Bošnjak N., Kraljević D. Antisperm antibodies and testicular blood flow after inguinal hernia mesh repair. Surg Endosc. 2014;28(12):3413-20. DOI: 10.1007/s00464-014-3614-7.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Черкасов Д.М., Керимов И.Э., Черкасов М.Ф., Наматян А.Б., Кучер Д.Д. Эффективность различных методов герниопластики у мужчин молодого возраста (обзор литературы). Московский хирургический журнал. 2024;3:185-195. DOI: 10.17238/2072-3180-2024-3-185-195.</mixed-citation><mixed-citation xml:lang="en">Cherkasov D.M., Kerimov I.E., Cherkasov M.F., Namatyan A.B., Kucher D.D. Efficacy of various hernioplasty techniques in young male patients: a literature review. Moscow Surgical Journal. 2024;3:185-195. (In Russ.). DOI: 10.17238/2072-3180-2024-3-185-195.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Гаврилюк В.П., Северинов Д.А., Костин С.В., Донская Е.В., Зубкова Ю.А. Одномоментная герниопластика (PIRS) при лапароскопической аппендэктомии у детей. Эндоскопическая хирургия. 2024;30(1):55- 59. DOI: 10.17116/endoskop20243001155.</mixed-citation><mixed-citation xml:lang="en">Gavrilyuk VP, Severinov DA, Kostin SV, Donskaya EV, Zubkova YuA. Simultaneous hernioplasty (PIRS) during laparoscopic appendectomy in children. Endoscopic Surgery. 2024;30(1):55-59. (In Russ.). DOI: 10.17116/endoskop20243001155.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Cantay H., Ezer M., Binnetoglu K., Uslu M., Anuk T., Bayram H. et al. What is the effect of inguinal hernia operations on sexual functions? Cureus. 2022;14(4):e24137. DOI: 10.7759/cureus.24137.</mixed-citation><mixed-citation xml:lang="en">Cantay H., Ezer M., Binnetoglu K., Uslu M., Anuk T., Bayram H. et al. What is the effect of inguinal hernia operations on sexual functions? Cureus. 2022;14(4):e24137. DOI: 10.7759/cureus.24137.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Young L.J., Poynter D., Moss D. Quality of life following laparoscopic inguinal hernia surgery with self-adhesive mesh in 552 patients: a two-surgeon experience. ANZ J Surg. 2022;92(10):2487-2491. DOI: 10.1111/ans.17937.</mixed-citation><mixed-citation xml:lang="en">Young L.J., Poynter D., Moss D. Quality of life following laparoscopic inguinal hernia surgery with self-adhesive mesh in 552 patients: a two-surgeon experience. ANZ J Surg. 2022;92(10):2487-2491. DOI: 10.1111/ans.17937.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Damous S.H.B., Damous L.L., Borges V.A., Fontella A.K., Miranda J.D.S., Koike M.K. et al. Bilateral inguinal hernia repair and male fertility: a randomized clinical trial comparing Lichtenstein versus laparoscopic transabdominal preperitoneal (TAPP) technique. Surg Endosc. 2023;37(12):9263-9274. DOI: 10.1007/s00464-023-10499-8.</mixed-citation><mixed-citation xml:lang="en">Damous S.H.B., Damous L.L., Borges V.A., Fontella A.K., Miranda J.D.S., Koike M.K. et al. Bilateral inguinal hernia repair and male fertility: a randomized clinical trial comparing Lichtenstein versus laparoscopic transabdominal preperitoneal (TAPP) technique. Surg Endosc. 2023;37(12):9263-9274. DOI: 10.1007/s00464-023-10499-8.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Sahoo P.K., Patra S.K., Sahu M.K., Pati B.K., Mishra A.K. Evaluation of oxidative stress and antioxidant status in patients with inguinal hernia. J Clin Diagn Res. 2016;10(1):BC01-BC03.</mixed-citation><mixed-citation xml:lang="en">Sahoo P.K., Patra S.K., Sahu M.K., Pati B.K., Mishra A.K. Evaluation of oxidative stress and antioxidant status in patients with inguinal hernia. J Clin Diagn Res. 2016;10(1):BC01-BC03.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Rosenberg J., Baig S., Chen D.C., Derikx J. Groin hernia. Nat Rev Dis Primers. 2025;11(1):47. DOI: 10.1038/s41572-025-00631-4.</mixed-citation><mixed-citation xml:lang="en">Rosenberg J., Baig S., Chen D.C., Derikx J. Groin hernia. Nat Rev Dis Primers. 2025;11(1):47. DOI: 10.1038/s41572-025-00631-4.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
