<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">thealth</journal-id><journal-title-group><journal-title xml:lang="ru">Здравоохранение Таджикистана</journal-title><trans-title-group xml:lang="en"><trans-title>Health care of Tajikistan</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0514-2415</issn><publisher><publisher-name>Редакция журнала «Здравоохранение Таджикистана»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52888/0514-2515-2026-369-2-102-108</article-id><article-id custom-type="elpub" pub-id-type="custom">thealth-744</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Акушерские и перинатальные исходы у женщин с дородовым разрывом плодных оболочек в зависимости от срока родоразрешения</article-title><trans-title-group xml:lang="en"><trans-title>Obstetric and perinatal outcomes in women with premature rupture of membranes according to the timing of delivery</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-2621-2351</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хамидова</surname><given-names>Ф. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Khamidova</surname><given-names>F. Kh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хамидова Фаридабону Хуршедовна - аспирант</p><p>тел.: +992717031001</p><p>Душанбе </p></bio><bio xml:lang="en"><p>Khamidova Faridabonu Khurshedovna - is a postgraduate student</p><p>Dushanbe </p></bio><email xlink:type="simple">farida.06.01.99@icloud.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-7045-8310</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давлатзода</surname><given-names>Г. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Davlatzoda</surname><given-names>G. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Давлатзода Гулчахон Кобилчоновна - доктор медицинских наук, доцент, директор</p><p>Душанбе </p></bio><bio xml:lang="en"><p>Davlatzoda Guljakhon Kobilchonovna - MD, PhD, Associate Professor, Director</p><p>Dushanbe </p></bio><email xlink:type="simple">safarovfarid756@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9211-1124</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ишан-Ходжаева</surname><given-names>Ф. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Ishan-Khojaeva</surname><given-names>F. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ишан-Ходжаева Фарангис Рустамовна - кандидат медицинских наук, cтарший научный сотрудник акушерского отдела  </p><p>Душанбе </p></bio><bio xml:lang="en"><p>Ishan-Khodzhaeva Farangis Rustamovna – Candidate of Medical Sciences, Senior Researcher, Obstetrics Department</p><p>Dushanbe </p></bio><email xlink:type="simple">kachyona@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГУ «Таджикский научно-исследовательский институт акушерства, гинекологии и перинатологии»</institution><country>Таджикистан</country></aff><aff xml:lang="en"><institution>SI Tajik Research Institute of Obstetrics, Gynecology and Perinatology</institution><country>Tajikistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>02</day><month>07</month><year>2026</year></pub-date><volume>0</volume><issue>2</issue><fpage>102</fpage><lpage>108</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хамидова Ф.Х., Давлатзода Г.К., Ишан-Ходжаева Ф.Р., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Хамидова Ф.Х., Давлатзода Г.К., Ишан-Ходжаева Ф.Р.</copyright-holder><copyright-holder xml:lang="en">Khamidova F.K., Davlatzoda G.K., Ishan-Khojaeva F.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.zdrav.tj/jour/article/view/744">https://www.zdrav.tj/jour/article/view/744</self-uri><abstract><sec><title>Цель</title><p>Цель: изучить особенности клинико-социально-анамнестической характеристики женщин с дородовым разрывом плодных оболочек (ДРПО) в зависимости от срока родоразрешения.</p></sec><sec><title>Материал и методы</title><p>Материал и методы: проведен ретроспективный анализ 125 историй родов женщин с дородовым разрывом плодных оболочек. Обследованные женщины разделены на две группы – женщины с ДРПО, родившие в срок (СР) – 61 женщина и с ДРПО, родившие преждевременно (ПР) – 64 женщины. Все женщины прошли полное клинико-лабораторное и акушерское обследование, включая сбор анамнеза, общий осмотр, определение индекса массы тела (ИМТ), диагностику экстрагенитальных заболеваний и осложнений беременности. Статистическая обработка включала параметрические и непараметрические методы статистики.</p></sec><sec><title>Результаты</title><p>Результаты: выявлено статистически значимое повышение частоты синдрома задержки роста плода (СЗРП), индуцированных родов у женщин с ДРПО, родивших преждевременно по сравнению с соответствующими показателями женщин с ДРПО, родивших в срок. Перинатальные исходы ПР женщин с ДРПО характеризовались высокой частотой асфиксии новорожденных (31,3% и 4,9%, p &lt;0,001). Случаи перинатальной смертности зарегистрированы в 5 (7,8%) случаях при ПР среди новорожденных матерей с ДРПО и преждевременными родами.</p></sec><sec><title>Заключение</title><p>Заключение: таким образом, преждевременные роды у женщин с ДРПО следует рассматривать как состояние высокого перинатального риска, требующее раннего прогнозирования, стратификации, мониторинга и оптимизации тактики ведения беременности и родов.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: To evaluate the clinical, social, and medical history characteristics of women with premature rupture of membranes (PROM) according to the gestational age at delivery.</p></sec><sec><title>Material and Methods</title><p>Material and Methods: A retrospective analysis of 125 delivery records of women with premature rupture of membranes was conducted. The patients were divided into two groups: women with PROM who delivered at term (61 women), and women with PROM who delivered prematurely (64 women). All women underwent a full clinical, laboratory, and obstetric examination, including taking a medical history, physical examination, measurement of body mass index (BMI), identification of non-obstetric comorbidities, and pregnancy complications. Statistical analysis included parametric and non-parametric methods.</p></sec><sec><title>Results</title><p>Results: A statistically significant increase in the incidence of fetal growth restriction (FGR) and induced labor was noted in women with PROM who delivered prematurely compared to women with PROM who delivered at term. Perinatal outcomes of preterm delivery in women with PROM were characterized by a high frequency of neonatal asphyxia (31.3% vs. 4.9%, p &lt;0.001). Perinatal mortality was recorded in 5 instances (7.8%) among newborns of mothers with PROM and preterm labor.</p></sec><sec><title>Conclusion</title><p>Conclusion: Preterm delivery in women with PROM should be considered a condition of high perinatal risk, requiring early prediction, stratification, monitoring, and optimization of pregnancy and labor management.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>дородовый разрыв плодных оболочек</kwd><kwd>преждевременные роды</kwd><kwd>социальные характеристики</kwd><kwd>анамнестические характеристики</kwd><kwd>медицинские характеристики</kwd></kwd-group><kwd-group xml:lang="en"><kwd>premature rupture of membranes</kwd><kwd>preterm labor</kwd><kwd>social</kwd><kwd>anamnesis</kwd><kwd>medical characteristics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Шамсиева Д., Рузиева Н. Современные подходы к индукции родов при дородовом разрыве плодных оболочек: эффективность, безопасность, международные рекомендации. Евразийский журнал медицинских и естественных наук. 2025; 5(6 Part 2): 93–98.</mixed-citation><mixed-citation xml:lang="en">Shamsieva D., Ruzieva N. Modern approaches to labor induction in prelabor rupture of membranes: efficacy, safety, international recommendations. Eurasian Journal of Medical and Natural Sciences. 2025; 5(6 Part 2): 93–98.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Forde B, Fresch R, Masters H, et al. Comparison of Pregnancy Outcomes of Previable and Periviable Rupture of Membranes After Laser Photocoagulation for Twin-Twin Transfusion Syndrome. Obstet Gynecol. 2022; 140(6): 965-973.</mixed-citation><mixed-citation xml:lang="en">Forde B, Fresch R, Masters H, et al. Comparison of Pregnancy Outcomes of Previable and Periviable Rupture of Membranes After Laser Photocoagulation for Twin-Twin Transfusion Syndrome. Obstet Gynecol. 2022; 140(6): 965-973.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Wang X, Zhang X, Liu Y, et al. Effect of premature rupture of membranes on time to delivery and outcomes in full-term pregnancies with vaginal dinoprostone-induced labour. Arch Gynecol Obstet. 2020; 301(2): 369-374.</mixed-citation><mixed-citation xml:lang="en">Wang X, Zhang X, Liu Y, et al. Effect of premature rupture of membranes on time to delivery and outcomes in full-term pregnancies with vaginal dinoprostone-induced labour. Arch Gynecol Obstet. 2020; 301(2): 369-374.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Denicol MM, Leotti VB, Soares CRS, Hilgert JB. Early-onset neonatal sepsis as a risk factor for periintraventricular hemorrhage in premature infants. Rev Bras Epidemiol. 2024; 27: e240013.</mixed-citation><mixed-citation xml:lang="en">Denicol MM, Leotti VB, Soares CRS, Hilgert JB. Early-onset neonatal sepsis as a risk factor for periintraventricular hemorrhage in premature infants. Rev Bras Epidemiol. 2024; 27: e240013.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ağaoğlu RT, Öztürk Ö, Ulusoy CO, et al. Perinatal outcomes and predictors of neonatal mortality in preterm premature rupture of membranes: a tertiary center experience. BMC Pregnancy Childbirth. 2025; 25(1): 585.</mixed-citation><mixed-citation xml:lang="en">Ağaoğlu RT, Öztürk Ö, Ulusoy CO, et al. Perinatal outcomes and predictors of neonatal mortality in preterm premature rupture of membranes: a tertiary center experience. BMC Pregnancy Childbirth. 2025; 25(1): 585.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Seravalli V, Colucci C, Di Cencio C, et al. Latency to delivery and incidence of adverse obstetric and perinatal outcomes in preterm premature rupture of membranes before 32 weeks. Arch Gynecol Obstet. 2025; 311(6): 1569-1577.</mixed-citation><mixed-citation xml:lang="en">Seravalli V, Colucci C, Di Cencio C, et al. Latency to delivery and incidence of adverse obstetric and perinatal outcomes in preterm premature rupture of membranes before 32 weeks. Arch Gynecol Obstet. 2025; 311(6): 1569-1577.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Grill A, Mikula F, Jansen S, et al. Neonatal outcomes following previable rupture of membranes below 23 weeks’ gestation. Eur J Pediatr. 2025; 184(8): 503.</mixed-citation><mixed-citation xml:lang="en">Grill A, Mikula F, Jansen S, et al. Neonatal outcomes following previable rupture of membranes below 23 weeks’ gestation. Eur J Pediatr. 2025; 184(8): 503.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Pendse A, Panchal H, Athalye-Jape G, et al. Neonatal outcomes following previable prelabour rupture of membranes before 23 weeks of gestation - A retrospective cohort study. J Neonatal Perinatal Med. 2021; 14(1): 9-19.</mixed-citation><mixed-citation xml:lang="en">Pendse A, Panchal H, Athalye-Jape G, et al. Neonatal outcomes following previable prelabour rupture of membranes before 23 weeks of gestation - A retrospective cohort study. J Neonatal Perinatal Med. 2021; 14(1): 9-19.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ronzoni S, Cobo T, D’Souza R, et al. Individualized treatment of preterm premature rupture of membranes to prolong the latency period, reduce the rate of preterm birth, and improve neonatal outcomes. Am J Obstet Gynecol. 2022; 227(2): 296.e1-296.e18.</mixed-citation><mixed-citation xml:lang="en">Ronzoni S, Cobo T, D’Souza R, et al. Individualized treatment of preterm premature rupture of membranes to prolong the latency period, reduce the rate of preterm birth, and improve neonatal outcomes. Am J Obstet Gynecol. 2022; 227(2): 296.e1-296.e18.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lin N, Shi Y, Xia Y, et al. Risk Factors for Histologic Chorioamnionitis Among Women with Prenatal Fever During Preterm Delivery: A Retrospective Cohort Study. Int J Womens Health. 2025; 17: 3777-3788.</mixed-citation><mixed-citation xml:lang="en">Lin N, Shi Y, Xia Y, et al. Risk Factors for Histologic Chorioamnionitis Among Women with Prenatal Fever During Preterm Delivery: A Retrospective Cohort Study. Int J Womens Health. 2025; 17: 3777-3788.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Beck C, Gallagher K, Taylor LA, et al. Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis. Obstet Gynecol. 2021; 137(6): 1007-1022.</mixed-citation><mixed-citation xml:lang="en">Beck C, Gallagher K, Taylor LA, et al. Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis. Obstet Gynecol. 2021; 137(6): 1007-1022.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Kim MS, Kim S, Seo Y, et al. Impact of preterm premature rupture of membranes and oligohydramnios on in-hospital outcomes of very-low-birthweight infants. J Matern Fetal Neonatal Med. 2023; 36(1): 2195523.</mixed-citation><mixed-citation xml:lang="en">Kim MS, Kim S, Seo Y, et al. Impact of preterm premature rupture of membranes and oligohydramnios on in-hospital outcomes of very-low-birthweight infants. J Matern Fetal Neonatal Med. 2023; 36(1): 2195523.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
