IMMUNE STATUS OF PATIENTS AFTER RELATED TRANSPLANTATION OF THE KIDNEY ON THE BACKGROUND OF THE EARLY INFECTION AND SEPISIS

Abstract

Aim. To improve the results of related kidney transplantation by optimizing the treatment of bacterial complications.

Material and methods. The study included the results of 80 allotransplantations of the related kidney from 2011 to 2017 in the kidney transplant department of the NSCOTT and in the department of kidney transplantation of the Dangara regional hospital. The average follow-up time after kidney transplantation was 1276 ± 52 days. The study group included 56 (70 %%) men and 24 (30%) women.

The average age of recipients at the time of kidney transplantation was 38.19 ± 0.917 years, the median age was 39.0 years (14.4-62.5 years), the maximum age was 62.5 years and the minimum age was 14.4 years.

Results. Changes in the immune status of the kidney recipients against the background of wound infection and sepsis were analyzed. Revealed changes are confirming severe disorder in the humoral chain of the immune system.

Conclusion. In case of wound infection the concentration of C3 and C4 complement components changes insignificantly, and on the background of sepsis the С3 component decreases with a significant increase of C4 component, which indicates the launch of an alternative pathway for complement activation. The increase in the level of "cautious" proteins in case of wound infection and sepsis is observed.