RELATIONSHIP OF THE STATE OF BIOLOGICAL MEMBRANES WITH INDICATORS OF PRO - AND ANTIOXIDANT SYSTEM IN PATIENTS WITH PULMONARY TUBERCULOSIS
Abstract
Aim. To study the relationship between the state of biological membranes and indicators of pro - and antioxidant systems in patients with pulmonary tuberculosis.
Material and methods. The results of the examination of 60 patients with pulmonary tuberculosis, aged 19-63, who were treated at the National Tuberculosis Center of the Republic of Tajikistan, are presented.The patients were divided into two groups: drug-resistant form (MDR/TB) -28 (46.7%) and drug-sensitive form (MDR/TB) -32 (53.3%). The control group consisted of 30 healthy people, matched by age and sex.
Results. Analysis of the results showed that in MDR/TB, there was a more significant increase in ROS by 33.5%, MDA by 2.7 times, and a decrease in SOD by almost 2.0 times, respectively, in the control group. Less pronounced changes were observed in patients with MPH/TB. In the blood serum of patients with MLC/ TB, the content of ROS (Reactive oxygen species) increased by 17,1%, MDA by 2.0 times, and the SOD (Superoxide dismutase) activity decreased by 29% compared with the control group.
Conclusion. A characteristic of the course and progression of pulmonary tuberculosis is a combination of factors like hypoxia, oxidative stress, inflammation, accompanied by severe intoxication, characterizing damage to biological membranes, which are more pronounced in MDR/TB patients.
About the Authors
H. R. Nasyrdzhanova
SEI “Avicenna Tajik State Medical University”
Tajikistan
Tajikistan
Nasyrdzhanova Hursand Rakhimovna - Senior lecturer of the Biochemistry Department
Dushanbe
A. M. Saburova
SEI “Avicenna Tajik State Medical University”
Tajikistan
Tajikistan
Department of Biochemistry
Dushanbe
U. Yu. Sirodzhidinova
SEI “Avicenna Tajik State Medical University”
Tajikistan
Tajikistan
Department of Phthisiopulmonology
Dushanbe
U. E. Murodov
SEI “Avicenna Tajik State Medical University”
Tajikistan
Tajikistan
Department of Phthisiopulmonology
Dushanbe
References
1. Alacheva L. V. Otsenka morfofunktsionalnykh osobennostey perifericheskogo otdela eritrona u detey s patologiey organov dykhaniya [Evaluation of morphofunctional features of the peripheral erythrocytes in children with respiratory pathology]. Vestnik Yuzhno-Uralskogo gosudarstvennogo universiteta - Bulletin of the South Ural State University, 2010, No. 195 (19), pp. 38-42.
2. Bobokhojaev O.I., Mahmudzoda I.S., Gaibov A.G. Risk factors for tuberculosis in the Republic of Tajikistan
3. Borukaev A. M. Intervalnaya gipoksiterapiya v reabilitatsii bolnykh tuberkulyozom lyogkikh posle khirurgicheskogo lecheniya [Interval hypoxytherapy in the rehabilitation of pulmonary tuberculosis patients after surgical treatment]. Sovremennye problemy nauki i obrazovaniya - Modern problems of science and education, 2016, No. 1.
4. Borovskaya M. K. Strukturno-funktsionalnaya kharakteristika membrany eritrotsita i ee izmeneniya pri patologiyakh raznogo geneza [Structural and functional characteristics of the erythrocyte membrane and its changes in pathologies of different genesis]. Byulleten VSNTS SO RAMN - Bulletin of the Siberian Branch of the Russian Academy of Medical Sciences, 2010, No. 3 (73), pp. 334-351.
5. Boyborodov B. D. Vliyanie giperbaricheskoy oksigenatsii na pronitsaemost eritrotsitarnykh membran i sorbtsionnuyu sposobnost eritrotsitov u novorozhdennykh, perenesshikh gipoksiyu pri rozhdenii [Effect of hyperbaric oxygenation on erythrocyte membrane permeability and erythrocyte sorption capacity in newborns undergoing hypoxia at birth]. Anasteziologiya i reanimatologiya - Anesthesiology and Reanimatology, 2003, No. 2, pp. 55-57.
6. Gelberg V. N. Narushenie rezistentnosti metabolizma pri tuberkulyoze i metody patogeneticheskogo vozdeystviya v ego kompleksnom lechenii [Disruption of metabolic resistance in tuberculosis and methods of pathogenetic action in its complex treatment]. Zhurnal GGMU - Gomel State Medical University Journal, 2009, No. 1, pp. 123-128.
7. Kaminskaya G. O. Uchastie sistemy gemostaza v formirovanii sindroma sistemnogo vospalitelnogo otveta u bolnykh tuberkulyozom lyogkikh [Participation of the hemostasis system in the formation of systemic inflammatory response syndrome in pulmonary tuberculosis patients]. Tuberkulyoz i bolezni lyogkikh - Tuberculosis and lung disease, 2011, No. 2, pp. 52-58.
8. Muravlyova L. E. Kharakteristika eritrotsitov pri KHOBL [Characteristics of erythrocytes in COPD]. Sovremennye problemy nauki i obrazovaniya - Modern problems of science and education, 2014, No.5
9. Mishina N. A. Oksidantno-antioksidantnyy status eritrotsitov pri khronicheskoy obstruktivnoy bolezni lyogkikh [Oxidant-antioxidant status of erythrocytes in chronic obstructive pulmonary disease]. Vestnik Rossiyskogo universiteta druzhby narodov - Bulletin of Peoples’ Friendship University of Russia, 2010, No. 4, pp. 354-357.
10. Samoylova A. G. Effektivnost standartnykh rezhimov khimioterapii tuberkuleza v zavisimosti ot lekarstvennoy chuvstvitelnosti vozbuditelya [Efficacy of standard regimens of tuberculosis chemotherapy depending on the drug sensitivity of the pathogen]. Tuberkulez i bolezni legkikh - Tuberculosis and lung disease, 2012, No. 8, pp. 23–25.
11. Sanginov A.B., Latiphov M.J., Ali-zade S.G., Kievmiddinov Kh.Kh. Prevalence of tuberculosis in children and adolescents in the Republic of Tajikistan.
12. Soodaeva S. K. Mekhanizmy razvitiya oksidativnogo stressa pod vozdeystviem aeropollyutantov okruzhayushchey sredy: potentsial sredstva antioksidantnoy zashchity [Mechanisms of oxidative stress under the influence of environmental aero-pollutants: the potential of antioxidant protection agents]. Pulmonologiya - Pulmonology, 2015, No. 6, pp. 736-742.
13. Sirenko I. A. Sostoyanie perekisnogo okisleniya lipidov u detey i podrostkov s aktivnym tuberkulezom organov dykhaniya [Status of lipid peroxidation in children and adolescents with active respiratory tuberculosis]. Ukrainskiy pulmonologicheskiy zhurnal - Ukrainian pulmonological journal, 2004, No. 1, pp. 40-41
14. Nadeen A. Airway and systemic oxidant-antioxidant dysregulation in asthma a possible scenario of oxidant spill over from lung into blood. Pulmonary Pharmacology and Therapeutics, 2014, No. 29 (1), pp. 31-40
15. Montoya-Estrada A, Torres-Ramos YD, FloresPliego A. Urban PM 2.5 activates GAPDH and induces RBC damage in COPD patients. Frontiers in bioscience (Scholar edition), 2013, No. 5, pp. 638-649.
Review
For citations:
Nasyrdzhanova H.R., Saburova A.M., Sirodzhidinova U.Yu., Murodov U.E. RELATIONSHIP OF THE STATE OF BIOLOGICAL MEMBRANES WITH INDICATORS OF PRO - AND ANTIOXIDANT SYSTEM IN PATIENTS WITH PULMONARY TUBERCULOSIS. Health care of Tajikistan. 2021;(1):50-56. (In Russ.)
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