Peculiarities of infectious complications in children with acute lymphoblastic leukemia
Abstract
Aim. To study the results of treatment of infectious complications in children with acute lymphoblastic leukemia.
Materials and methods. Results of 255 courses of chemotherapy and treatment of infectious complications in 53 children with acute lymphoblastic leukemia were analyzed. Carbapenems were used as the main antibiotic.
Results and discussion. The use of antibiotics in the treatment of children with acute lymphoblastic leukemia was necessary for 53 (20.8%)patients. The indication for antibiotic therapy in 18 cases was bronchopneumonia, in consolidation (1.9%) and induction (31.1%), respectively. An infectious process in the soft tissues (furuncle, carbuncle, and hidradenitis) resulted in the need for antibiotics in 3 (6.7%) children during induction and in 5 (2.4%) children during consolidation. In cases of hyperthermia of unclear etiology, antibiotics were used in 5 (11.1%) children during induction and in 7 (3.3%) children during consolidation. In 7 (15.5%) children during induction and 3 (1.4%) children during consolidation, bacteremia was detected and antibacterials were used.
Conclusion. In children with acute lymphoblastic leukemia, the cause of infectious complications is more often gram-negative than gram-positive bacteria.
About the Authors
I. I. Karaev
Ministry of Health and Social Development of the Republic of Tajikistan
Tajikistan
Tajikistan
R. Z. Yuldashev
GOU TSMU named after Abuali ibni Sino
Tajikistan
Tajikistan
Yuldoshev Ravshan Zoidovich - Doctor of Medical Sciences, Head. Department of Oncology and Radiation Diagnostics
Dushanbe
Tel.: 918679399
Z. A. Madaminova
GOU TSMU named after Abuali ibni Sino
Tajikistan
Tajikistan
Department of Oncology and Radial Diagnostics
Dushanbe
S. A. Bokiev
GOU TSMU named after Abuali ibni Sino
Tajikistan
Tajikistan
Department of Oncology and Radial Diagnostics
Dushanbe
N. G. Rakhimov
Ministry of Health and Social Development of the Republic of Tajikistan
Tajikistan
Tajikistan
Z. M. Mavlonova
GOU TSMU named after Abuali ibni Sino
Tajikistan
Tajikistan
Department of Oncology and Radial Diagnostics
Dushanbe
References
1. Balasheva I. I. 50 let kliniko-epidemiologicheskikh issledovaniy ostrykh leykozov u detey Tomskoy oblasti [50 Years of Clinical and Epidemiological Studies of Acute Leukemia in Children living in Tomsk Oblast]. Sibirskiy onkologicheskiy zhurnal - Siberian journal of Oncology, No. 1, 2010, pp. 23-28.
2. Beyn B. Dzh. Khronicheskie mieloidnye leykozy: atlas-spravochnik [Chronic Myeloid Leukemia: Atlas Guide]. Moscow, Granat Publ., 2014. 58 p.
3. Bondarenko C. H., Semenova E V., Afanasev B.V. Allogennaya transplantatsiya gemopoeticheskikh stvolovykh kletok pri ostrom mieloblastnom leykoze v pervoy remissii [Allogeneic hematopoietic stem cell transplantation for acute myeloblastic leukemia in first remission]. Terapevticheskiy arkhiv - Therapeutic Archive, 2013, Vol. 84 (7), pp. 18-25.
4. Murodov M. D. Narusheniya mikroflory kishechnika u detey pri ostrom limfoblastnom leykoze [Gut microflora disorders in children with acute lymphoblastic leukemia]. Pediatriya i detskaya khirurgiya Tadzhikistana - Pediatrics and Pediatric Surgery in Tajikistan, 2013, No. 2, pp. 7-15.
5. Nabiev Z. N. Profilaktika oslozhneniy posle khimioterapii u detey s leykozom [Prevention of complications after chemotherapy in children with leukemia]. Zdravookhranenie Tadzhikistana – Healthcare of Tajikistan, 2015, No. 4, pp. 14-17.
6. Parovichnikova E. N. Klinicheskiy protokol OML-01.10 po lecheniyu ostrykh mieloidnykh leykozov vzroslykh [Clinical Protocol OМЛ-01.10 for the treatment of adult acute myeloid leukemia]. Programmnoe lechenie zabolevaniy sistemy krovi - Software treatment of diseases of the blood system, 2012, pp. 153-206.
7. Toropova I. Yu. Klinicheskiy monitoring infektsionnykh oslozhneniy u bolnykh gemoblastozami na fone programmnoy khimioterapii [Clinical monitoring of infectious complications in hemoblastosis patients against the background of programmed chemotherapy]. Gematologiya i transfuziologiya - Hematology and Transfusiology, 2011, No. 6, pp. 10.
8. Khodzhieva G. B. Kliniko-gematologicheskie osobennosti ostroy leykemii v Tadzhikistane [Clinical and Hematological Features of Acute Leukemia in Tajikistan]. Vestnik Avitsenny – Herald of Avicenna, 2013, No. 4, pp. 36-39.
9. Antar A. Otrock ZK. Kharfan-Dabaja M. et al. Azacitidine in the treatment of extramedullary relapse of AML after allogeneic hematopoietic cell transplantation. Bone Marrow Transplant, 2013, No. 48 (7), pp. 994-995.
10. Greenberg PL. Stone RM. Al-Kali A. et al Clinical Practice Guidelines in Oncology. Myelodysplastic Syndromes. Version 2.2017. Journal of the National Comprehensive Cancer Network, 2017, No. 15, pp. 60-87.
Review
For citations:
Karaev I.I., Yuldashev R.Z., Madaminova Z.A., Bokiev S.A., Rakhimov N.G., Mavlonova Z.M. Peculiarities of infectious complications in children with acute lymphoblastic leukemia. Health care of Tajikistan. 2020;(4):28-33. (In Russ.)
Views:
272
Email this article 