Some clinical and epidemiological aspects of HIV/ hepatitis C coinfection
https://doi.org/10.52888/0514-2515-2023-356-1-66-72
Abstract
Aim. To study some clinical and epidemiological aspects of HIV/hepatitis C coinfection in the Republic of Tajikistan.
Materials and methods. The material for the study was the data from clinical, epidemiological and virological examinations of 70 patients with HIV/hepatitis C coinfection. In all observed patients, the diagnosis was confirmed based on clinical and epidemiological data and confirmed by rapid testing, ELISA, and PCR.
Results discussion. The disease in patients with HIV/hepatitis C coinfection clinically proceeds with weakness and general malaise (92.8%), loss of appetite (67.1%), heaviness in the liver (45%), heartburn (25%), bitterness in the mouth (19%), nausea and anorexia (32.8%), bleeding from the gums (13%), yellowness of the sclera (11.4%), weight loss (41.4%), hepatomegaly (83%). Opportunistic pathology is represented by candidiasis (32.8%), herpes infection (22.8%), CMV (7.1%), pneumocystis pneumonia (4.2%), Kaposi’s sarcoma (4.2%), cerebral toxoplasmosis (1.4%). People who practice intravenous drug administration, as well as their sexual partners, are more likely to be infected. It has been established that males under the age of 45 predominate among coinfected patients. As for secondary and opportunistic infections, they are associated with a decrease in the immune status in the face of CD4+ - lymphocytes in patients with coinfection.
Conclusion. The studies carried out make it possible to identify the category of people most at risk of infection with HIV and hepatitis C, which must be taken into account when screening the population. Early diagnosis of HIV/ hepatitis C coinfection will help reduce the number of complications and mortality in this category of patients.
About the Author
J. E. Rakhmonov
Department of Infectious Diseases, State Educational Institution Avicenna Tajik State Medical University
Tajikistan
Tajikistan
Rakhmonov Jamshed Erkinovich - applicant
Dushanbe
Tel.: +992919643312
References
1. Azovtseva O.V. Kliniko-genotipicheskaya kharakteristika koinfektsii virusnogo gepatita S i VICh [Clinical and genotypic characteristics of viral hepatitis C and HIV co-infection]. VICh infektsiya i immunosupressii - HIV infection and immunosuppression, 2010, pp. 37-42.
2. Badosova N.V. Audit ambulatornykh kart kak sredstvo otsenki i monitoringa kachestva okazaniya meditsinskoy pomoshchi bolnym s VICh-infektsiey [Audit of outpatient records as a means of assessing and monitoring the quality of care for patients with HIV infection]. VICh infektsiya i immunosupressii - HIV infection and immunosuppression, 2011, Vol. 3, No. 1, pp. 21-25.
3. Bartlett D. Klinicheskie aspekty VICh-infektsii [Clinical aspects of HIV infection]. Moscow, Valent Publ., 2010. 490 p.
4. Belyakov N.A. Polovoy put peredachi VICh v epidemii [Sexual transmission of HIV in the epidemic]. VICh infektsiya i immunosupressii - HIV infection and immunosuppression, 2011, Vol. 3, No. 4, pp. 7-20
5. Dzhurakulova F.M. Epidemicheskaya situatsiya po VICH-infektsii v g. Dushanbe Respubliki Tadzhikistan [The epidemic situation of HIV infection in Dushanbe, Tajikistan]. Meditsinskiy vestnik natsionalnoy Akademii nauk Tadzhikistana – Medical Herald of the National Academy of Science of Tajikistan, 2021, Vol. 9, No. 3 (39), pp. 24-30.
6. Pirogova I.A. Rasprostranyonnost VICh-infektsii v Rossii [HIV prevalence in Russia]. Vestnik Soveta molodykh uchyonykh i spetsialistov Chelyabinskoy oblasti - Bulletin of the Council of Young Scientists and Specialists of the Chelyabinsk region, 2017, Vol. 2, No. 4 (19), pp. 45-49.
7. Polyakova A.N. Novyy klass antiretrovirusnykh preparatov —antagonisty koretseptora CCR5 [A new class of antiretroviral drugs - CCR5 co-receptor antagonists]. VICh infektsiya i immunosupressii - HIV infection and immunosuppression, 2010, No. 3, pp. 73-81.
8. Pokrovskiy V.V. VICh-infektsiya i SPID. Klinicheskie rekomendatsii [HIV infection and AIDS. Clinical Recommendations.]. Moscow, GEOTAR-Media Publ., 2010. 192 p.
9. Rafiev Kh.K. Osobennosti VICH/SPID v sovremennykh usloviyakh sredi naseleniya i osuzhdyonnykh [Peculiarities of HIV/AIDS in modern conditions among the population and inmates]. Vestnik Avitsenny - Avicenna Bulletin, 2017, Vol. 19, No. 2, pp. 249-253.
10. Rakhmanova A.G. Antiretrovirusnaya terapiya VICH-infektsii v Sankt-Peterburge i perspektivy ee sovershenstvovaniya [Antiretroviral therapy for HIV infection in St. Petersburg and prospects for its improvement]. VICh infektsiya i immunosupressii - HIV infection and immunosuppression, 2011, No. 4, pp. 44-50.
11. Ruziev M.M. Rezultaty vnedreniya dozornogo epidemiologicheskogo nadzora za VICH-infektsiey v Respublike Tadzhikistan [Results of the implementation of sentinel epidemiological surveillance of HIV infection in the Republic of Tajikistan]. Meditsinskiy vestnik natsionalnoy Akademii nauk Tadzhikistana – Medical Bulletin of the National Academy of Science of Tajikistan, 2017, No. 3, pp. 78-82.
12. Smolskaya T.T. Profilaktika VICh-infektsii i eyo rol v kontekste budushchego epidemii v Rossiyskoy Federatsii [HIV Prevention and its Role in the Future of the Epidemic in the Russian Federation]. Ekologiya cheloveka - Ecology of Human, 2012, No. 2, pp. 47-54.
13. Tursunov R.A. Koinfektsiya VICH i parenteralnye virusnye gepatity u narkozavisimykh [HIV co-infection and parenteral viral hepatitis in drug addicts]. Vestnik Avitsenny - Avicenna Bulletin, 2012, No. 2, pp. 82-89.
Review
For citations:
Rakhmonov J.E. Some clinical and epidemiological aspects of HIV/ hepatitis C coinfection. Health care of Tajikistan. 2023;(1):66-72. (In Russ.) https://doi.org/10.52888/0514-2515-2023-356-1-66-72
Views:
258
Email this article 