Antiviral and antibacterial properties of plants of the genus Ferula L.
https://doi.org/10.52888/0514-2515-2025-364-1-115-123
Abstract
This article presents a literature review on the antiviral and antibacterial properties of Ferula L. species. Extracts and gums from different species of this plant genus have been used in traditional medicine since ancient times and are still used today. All relevant databases including Science Direct, Web of Science, Scopus, PubMed, EBSCO were searched without restriction using the terms “Ferula”, “antiviral”, “anti-influenza”, “anti-fungal” up to 01 June 2024. Keywords were also entered into popular search engines such as Google and Google Scholar. According to the literature, it can be concluded that many representatives of this plant species have strong antiviral, antibacterial and antifungal properties. However, there is no information in the literature on the biological activity of Ferula L. species growing in Tajikistan.
About the Authors
S. Satorov
NEI Medical and Social Institute of Tajikistan
Tajikistan
Tajikistan
S. N. Mavlonazarova
SEI Avicenna Tajik State Medical University
Tajikistan
Tajikistan
Mavlonazarova Sulkhiya Noyobshoevna - postgraduate student
Tel.: +992559993188
S. J. Yusufi
SEI Avicenna Tajik State Medical University
Tajikistan
Tajikistan
References
1. Satorov S. Virusingibiruyushchiy effekt rasteniya vida FerulaKuhistanicaKorovin, proizrastayushchego v vysokogornykh usloviyakh Respubliki Tadzhikistan [Virusinhibitory effect of Ferula Kuhistanica Korovin species growing in high mountainous conditions of the Republic of Tajikistan]. Zdravookhranenie Tadzhikistana – Healthcare of Tajikistan, 2023, No. 2, pp. 100-105
2. Satorov S. Issledovanie antibakterialnoy aktivnosti ekstraktov razlichnykh vidov roda Allium, proizrastayushchikh v Tadzhikistane [Study of antibacterial activity of extracts of different species of Allium genus growing in Tajikistan]. Vestnik Avitsenny – Avicenna Bulletin, 2021, Vol. 23, No. 2, pp. 216-34.
3. Satorov S.Soderzhanie obshchikh polifenolov i antioksidantnaya aktivnost rasteniy roda Allium i ikh korrelyatsiya s antibakterialnoy i protivogribkovoy aktivnostyu [Content of total polyphenols and antioxidant activity of plants of Allium genus and their correlation with antibacterial and antifungal activity]. Zdravookhranenie Tadzhikistana – Healthcare of Tajikistan, 2021, No. 2 (349), pp. 85-97.
4. Abascal K. Herbal treatments for pandemic influenza. Learning from the eclectics’ experience Alternative & Complementary Therapies, 2006, Vol. 12, No. 5, pp. 214–221.
5. Ahmadi Koulaei S. Chemical composition and biological activity of Ferulaaucheri essential oil. Research Journal of Pharmacognosy, 2020, Vol. 7, No. 2, pp. 21-31.
6. Baldemir A. Antimicrobial activity of Ferula halophila Peflmen. FABAD Journal of Pharmaceutical Sciences, 2006, No. 31, pp. 57-61.
7. Daneshkazemi A. et al. Antimicrobial Activity of the essential oil obtained from the seed and oleo-gum-resin of Ferula AssaFoetida against oral pathogens. Front Dent, 2019, Vol. 16, No. 2, pp. 113-120.
8. Dastan D. Disesquiterpene and sesquiterpene coumarins from Ferulapseudalliacea, and determination of their absolute configurations. Phytochemistry, 2012, No. 78, pp. 170-78.
9. Dastan D. Chemical composition and bioactivities of essential oils from different plant parts of Ferula pseudalliacea Rech.f. as an endemic plant from Iran. Natural Product Research, 2022, Vol. 36, No. 5, pp. 1311–1316.
10. Dissanayake, K.G.C. Medicinal importance of Ferula asafetida oligo- gum resins against infective diseases. Research Journal of Medicinal Plant, 2020, No. 8, pp. 135-139.
11. Ed-DahmaniI, Evaluation of Polyphenolic Content, Antioxidant and Antimicrobial Activities, and Toxicity Study of Ferula communis L. Tropical Journal of Natural Product Research, 2024, Vol. 8, No. 2, pp. 6423-6432.
12. Fani M.M. An in Vitro Study on the Antibacterial Effect of FerulaAssa-Foetida L. and Quercus Infectoria Olivier Extracts on Streptococcus Mutans and Streptococcus Sanguis. Avicenna Journal of Dental Research, 2015, Vol. 7, No. 1.
13. Fossum E. Antigenic drift and immunity gap explain reduction in protective responses against influenza A(H1N1) pdm09 and A(H3N2) viruses during the COVID-19 pandemic: a cross-sectional study of human sera collected in 2019, 2021, 2022, and 2023. Virology Journal, 2023, No. 21 (57).
14. Galal A.M. Daucane sesquiterpenes from Ferulahermonis. Journal of Natural Products, 2001, Vol. 64, No. 3, pp. 399-400.
15. Gao T.T., Yu F.H., Tan Y. Study on Antimicrobial Activity in vitro of Extracts from Three Species of Ferula Root. Beifang Yuany, 2013, No. 24, pp. 156–158.
16. Ghannadi A., Fattahian K., Shokoohinia Y. Anti-Viral Evaluation of Sesquiterpene Coumarins from Ferula Assa-Foetida against HSV-1. Iranian Journal of Pharmaceutical Research, 2014, No. 13 (2), pp. 523-530.
17. Gunther R.T. The Greek Herbal of Dioscorides. London, Hafner Publ., 1968.
18. Kahraman C., Topcu G., Bedir E. Phytochemical screening and evaluation of the antimicrobial and antioxidant activities of Ferula caspica M. Bieb. extracts. Saudi Pharmaceutical Journal, 2019, No. 27 (4), pp. 525-531.
19. Kavaz D., Faraj R.E. Investigation of composition, antioxidant, antimicrobial and cytotoxic characteristics from Juniperussabina and Ferulacommunis extracts. Science Reports, 2023, No. 13, pp. 7193.
20. Korovin E.P. Genus Ferula L. Flora of the USSR. 1951, pp. 62-142.
21. Kurkcuoglu M., Iscan G., Tosun F., Miski M. Biological activity and chemical composition of the essential oil from the fruits of Ferula halophila Peşmen. ACTA Pharmaceutica Sciencia, 2023, Vol. 61, No. 1.
22. Lee C.L., Chiang L.C., Cheng L.H. Influenza A (H1N1) antiviral and cytotoxic agents from Ferulaassa-foetida. Journal of Natural Products, 2009, No. 72 (9), pp. 1568-72.
23. Liu T., Osman K., Kaatz G.G., Simon M. Q. Antibacterial Sesquiterpenoid Derivatives from Ferulaferulaeoides. Planta medica, 2013, No. 79, pp. 10.
24. Mahdizadeh S., Khaleghi G.M., Gorji A. Avicenna’s Canon of Medicine: a review of analgesics and anti-inflammatory substances. Avicenna Journal of Phytomedicine, 2015, Vol. 5 (3), pp. 182-202.
25. Mareshah A., Schroeder S., Goelz L. Antimicrobial activity of the volatile substances from essential oils. BMC Complementary Medicine and Therapies, 2021, No. 21, pp. 11-14.
26. Mashael W. Alruways. Antimicrobial effects of Ferula species- an herbal tactic for management of infectious diseases. Journal of King Saud University. Science, 2023, pp. 102806
27. Moradi M., Karimi A., lorigooini Z. In vitro anti influenza virus activity, antioxidant potential and total phenolic content of twelve Iranian medicinal plants. Marmara Pharmaceutical Journal, No. 21(4), pp. 843-851.
28. Nunn J.F. Ancient Egyptian medicine. Transactions of the Medical Society of London, 1996, No. 113, pp. 57-68.
29. Pavlović I., Petrović S., Radenković M., Milenković M., et al. Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil. Food Chemistry, 2012, Vol. 130, No. 2, pp. 310-315.
30. Richa B., Rani R., Dang A.S. Antibacterial activity of Ferulaasafoetida: a comparison of red and white type. Journal of Applied Biology and Biotechnology, 2015, No. 3, pp. 0-2.
31. Safi R., El-Sabban M., Najjar F. Ferula hermonis: A Review of Current Use and Pharmacological Studies of its Sesquiterpene Ester Ferutinin. Curr Drug Targets, 2020, No. 21 (5), pp. 499-508.
32. Satorov S., Mirzoeva F.D, Satorov Sh.S. Comparative characteristic of antibacterial activity of plants growing in the central part of the Republic of Tajikistan. Avicenna Bulletin, 2019, No. 4 (21), pp. 643-653.
33. Sharopov F., Braun M.S., Gulmurodov I., Khalifaev D., Isupov S., Wink M. Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Essential Oils of Selected Aromatic Plants from Tajikistan. Foods, 2015, No. 4 (4), pp. 645-653.
34. Tosun F., Göger F. Activities of the Fruit Essential Oil, Fruit, and Root Extracts of Feruladrudeana Korovin, the Putative Anatolian Ecotype of the Silphion Plant. Plants, 2023, No. 12, pp. 830.
35. Tuncay H.O., Akalın E., Doğru‐Koca A., Eruçar F.M., Miski M. Two New Ferula (Apiaceae) Species from Central Anatolia: Ferula turcica and Ferula latialata. Horticulturae, 2023, No. 9, pp. 144.
36. Xu H., Dickschat, J.S. Germacrene B—A Central Intermediate in Sesquiterpene Biosynthesis. Beilstein Journal of Organic Chemistry, 2023, No. 19, pp. 186–203.
37. Zellagui A., Gherraf N., Hegazy M., Akkal S., Rhouati S., Dendougui H. Phytochemical investigation and antimicrobial activity of crude extract of the roots of Ferula vesceritensis. Chemistry of Natural Compounds, 2012, No. 48, pp. 891–892.
38. Zellagui A., Gherraf N., Rhouati S. Chemical composition and antibacterial activity of the essential oils of Ferulavesceritensis Coss et Dur. leaves, endemic in Algeria. Organic and Medicinal Chemistry Letters, 2012, No. 2, pp. 31.
39. Zomorodian K., Saharkhiz J., Pakshir K. The composition, antibiofilm and antimicrobial activities of essential oil of Ferula assafoetida oleo-gum-resin. Biocatalysis and Agricultural Biotechnology, 2018, No. 14, pp. 300-304.
Review
For citations:
Satorov S., Mavlonazarova S.N., Yusufi S.J. Antiviral and antibacterial properties of plants of the genus Ferula L. Health care of Tajikistan. 2025;(1):115-123. (In Russ.) https://doi.org/10.52888/0514-2515-2025-364-1-115-123
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