Preview

Health care of Tajikistan

Advanced search

Modern perspective on the features and risk factors of erectile dysfunction in older men

https://doi.org/10.52888/0514-2515-2025-367-4-135-143

Abstract

Erectile dysfunction (ED) is a significant problem among older men, greatly affecting their quality of life. The risk of developing ED increases with age and is associated with various factors, including age-related changes, reduced testosterone levels, hypertension, diabetes, and metabolic syndrome. Endothelial dysfunction plays a central role in the pathogenesis of ED. Effective treatment of ED in elderly men requires measures aimed at lifestyle modification (weight loss, smoking cessation, physical activity), pharmacotherapy (phosphodiesterase 5 inhibitors), and, when necessary, testosterone replacement therapy. In cases where medication is ineffective, alternative treatments such as vacuum devices or intracavernosal injections may be used. Psychological support also plays an essential role in successful treatment. Early diagnosis and a comprehensive approach to treatment can significantly improve patient outcomes and enhance their quality of life. 

About the Authors

N. S. Ibodzoda
SI Republican Scientific and Clinical Urology Center
Tajikistan

Ibodzoda Nematulloh Sohib – Director

Dushanbe



M. B. Fakhridinov
SI Republican Scientific and Clinical Urology Center
Tajikistan

Fakhridinov Mukhsidin Badridinovich – Researcher

Dushanbe



Kh. N. Najmidinov
Department of Urology named after Professor A.S. Osimi, SEI Avicenna Tajik State Medical University
Tajikistan

Najmidinov Khurshedjon Najmidinovich – PhD candidate at the Department of Urology named after Professor A.S. Osimi

Dushanbe



References

1. Apolikhin O.I., Lukash T.S., Efremov E.A., Krasnyak S.S. A modern perspective on the issue of erectile dysfunction in patients after surgical correction of cardiovascular diseases (literature review). Experimental and Clinical Urology. 2015;(1):72–77. (In Russ.).

2. Garanin A.A., Ryabov A.E., Bulgakova S.V. Endothelial dysfunction in patients with type 1 and type 2 diabetes mellitus. Cardiovascular Therapy and Prevention. 2012;11(S2):32. (In Russ.).

3. Kadyrov Z.A., Odilov A.Y., Sadulloev F.S. Erectile dysfunction in kidney diseases: literature review. Andrology and Genital Surgery. 2021;22(1):13–20. DOI: 10.17650/1726-9784-2021-22-1-13-20. (In Russ.).

4. Kadyrov Z.A., Odilov A.Y., Sadulloev F.S., Faniev M.V., Suleymanov S.I. Erectile dysfunction in patients after kidney transplantation and nephrectomy: literature review. Andrology and Genital Surgery. 2023;24(1):57– 65. (In Russ.).

5. Kurbatov D.G., Rozhivanov R.V., Priymak D.V. Erectile dysfunction in patients with diabetes mellitus (literature review). Russian Medical Journal. 2009;17(25):1672–1676. (In Russ.).

6. Mustafina V.I., Prokopyev Y.V., Guryev E.N. Venocorporeal erectile dysfunction as an indicator of pelvic venous blood flow dysfunction. In: Proceedings of the XXII Congress of the Russian Society of Urologists: Collection of Abstracts; 2022 Sep 14–17; Moscow. Moscow; 2022:474–475. (In Russ.).

7. Ongarbekov O.O., Turap A.T., Akylbekov N.M. [et al.] Sexual dysfunction in men in Europe and Central Asia. Bulletin of Science and Education. 2017;1(12):100– 102. (In Russ.).

8. Povelitsa E.A., Dost N.I., Domantsevich V.A. Modern methods for diagnosing vascular erectile dysfunction. Medicine (Minsk). 2016;(1):34–40. (In Russ.).

9. Pushkar D.Y., Govorov A.V., Kovalenko A.A. Epidemiological study of the prevalence of erectile dysfunction in the Russian Federation. Ural’skii Meditsinskii Zhurnal [Ural Medical Journal]. 2012;95(3):12-18. (In Russ.).

10. Sharofova M.U., Sagdiyeva S.S., Yusufi S.D. Diabetes mellitus: current state of the issue (part 1). Avicenna Bulletin. 2019;21(3):502–512. (In Russ.).

11. Akgul B., Aydin A., Cakir O.O. Impact of minimally invasive surgical therapies on sexual function in benign prostatic hyperplasia: a systematic review. Minerva Urol Nephrol. 2025;77(4):459–471. DOI: 10.23736/ S2724-6051.25.06374-8.

12. Chen H., Gao Z., Lin X. [et al.] Endothelin-1 and diabetes mellitus-induced erectile dysfunction: from pathogenesis to therapeutic potential. Diabetes Res Clin Pract. 2025; 226:112352. DOI: 10.1016/j. diabres.2025.112352.

13. Chen M.K., Li K.C., Feng J.L. [et al.] [Tonifying kidney and activating blood therapy for the treatment of diabetic erectile dysfunction: A systematic review and meta-analysis]. Zhonghua Nan Ke Xue. 2025;31(9):832–840.

14. Feng H.M., Liu S., Fu Q. [Influence of hypertension and antihypertensive drugs on erectile dysfunction and the underlying mechanism: An update]. Zhonghua Nan Ke Xue. 2024;30(11):1036–1042.

15. Ghavam A., Sheikhnia F., Heidari M.M. [et al.] An updated narrative review on revolutionizing erectile dysfunction treatment: the crucial role of trophic factors in Adipose-Derived stem cell therapy. BMC Urol. 2025;25:206. DOI: 10.1186/s12894-025-01861-0.

16. Hostnik B., Tonin G., Janež A., Klen J. Erectile Dysfunction in Diabetes Mellitus: A Comprehensive Narrative Review of Pathophysiology, Genetic Association Studies and Therapeutic Approaches. Endocrinol Diabetes Metab. 2025;8(5): e70099. DOI: 10.1002/edm2.70099.

17. Li Z., Zhang P.H., Liu M.J., Zhang T. [Statin drugs for the treatment of erectile dysfunction: An umbrella review]. Zhonghua Nan Ke Xue. 2025;31(7):637–644.

18. Liu W.L., Xu J., Du H.L., Zhang W.J. [Dietary intervention to improve erectile dysfunction: Progress in research]. Zhonghua Nan Ke Xue. 2025;31(9):841– 845.

19. Morcos M., Jeryous Fares B., Golrokhian-Sani A.A. [et al.] Prevalence of mental health evaluation in erectile dysfunction clinical trials. J Sex Med. 2025;22(9):1665–1672. DOI: 10.1093/jsxmed/qdaf173.

20. Raharinavalona S.A., Ranjandriarison T.D., Razanamparany T. [et al.] Prevalence of Erectile Dysfunction in Malagasy Patients with Diabetes Mellitus and Its Associations with Atherosclerotic Cardiovascular Diseases: A Cross-Sectional Study. Endocrinol Diabetes Metab. 2025;8(5):e70098. DOI: 10.1002/edm2.70098.

21. Vishwakarma R., Koshy A.J., Kalath H. [et al.] Toward Natural Products-Based Drug Development for Erectile Dysfunction: A Molecular Candidate from Plant «Tribulus terrestris» Identified by an Integrated «In Silico» Study. OMICS. 2025;29(9):442–457. DOI: 10.1177/15578100251370567.

22. Xiang L., Liu A., Tang W. [et al.] Phosphodiesterase type 5 inhibitors combined with traditional Chinese medicine for diabetes mellitus-induced erectile dysfunction: A systematic review and meta-analysis. Medicine (Baltimore). 2025;104(28):e43243. DOI: 10.1097/MD.0000000000043243.

23. Yu M., Li Z., Zeng H. [et al.] The association between lipid accumulation product and erectile dysfunction in hypertensive and diabetic men: a cross-sectional analysis of NHANES 2001- 2004. Aging Male. 2025;28(1):2563391. DOI: 10.1080/13685538.2025.2563391.


Review

For citations:


Ibodzoda N.S., Fakhridinov M.B., Najmidinov Kh.N. Modern perspective on the features and risk factors of erectile dysfunction in older men. Health care of Tajikistan. 2025;(4):135-143. (In Russ.) https://doi.org/10.52888/0514-2515-2025-367-4-135-143

Views: 168

JATS XML


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 0514-2415 (Print)