Clinical and radiographic evaluation of efficiency of plasmolifting in complex therapy of peri-implant mucositis

Objective: To evaluate the efficiency of the autologous platelet-rich plasma (PRP) in the comprehensive treatment of peri-implant mucositis.

Material and Methods: The study included 38 patients (11 men, 27 women) aged 35 to 50 years. Injections of autologous PRP, aimed at macrophage reprogramming, were administered in an outpatient setting using the following protocol: venous blood was drawn from patients in a volume of 450-475 ml into a plastic container. Following centrifugation, the plasma was isolated and administered locally into the mucobuccal fold of the affected area. The number of injections varied from 5 to 10, depending on the severity of the inflammatory process. The volume of plasma administered per procedure was 1.0 ml. Patients were discharged 10 minutes post-injection, provided they felt well and maintained stable blood pressure. Clinical and radiographic examinations were utilized to monitor the status of the peri-implant tissues.

Results: Following the treatment course, which lasted between 5 and 10 days depending on the severity of peri-implant mucositis, the majority of patients showed a complete resolution of clinical symptoms. One patient was an exception, exhibiting residual signs of mucositis, which were successfully resolved following a repeated course of comprehensive therapy. At baseline, the peri-implant probing depth was maximal in the study participants, likely due to inflammatory edema. Upon completion of treatment and during subsequent follow-up, a statistically significant reduction in this parameter was observed.

Conclusion: Macrophage reprogramming was effective in patients with peri-implant mucositis. The high rate of inflammation resolution in the peri-implant tissues (97.4%) demonstrates the clinical efficacy of this oral macrophage reprogramming approach. Furthermore, the rapid elimination of inflammatory symptoms confirms the therapeutic value of these reprogramming interventions in the management of peri-implant mucositis.

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