The state of lipid peroxidation and antioxidant protection under ischemic heart disease under mountain conditions

Aim. To assess the state of lipid peroxidation and antioxidant protection in patients with coronary heart disease (CHD) living in various high-altitude regions of Tajikistan. Material and methods. All 430 examined patients with CHD were residents of mountain regions of various altitudes. Based on altitude patients were divided into following groups: low mountains - 150 patients (Dushanbe, 860 m a.s.l.), mid mountains - 140 patients (Khorog, 2200 m a.s.l.) and high mountains - 140 patients (Murgab, 3600 -5600 m a.s.l.). The control group comprised 25 healthy people, the age of 55-65, living at an appropriate altitude.Results and discussion. More explicit and progressive changes in the primary part of the oxidation process are found among patients of high altitude mountain regions that can be described as a progressive increase of oxidative stress. It is confirmed by the excess of primary products of lipid peroxidation (LP) by 3 times (0.317-0.02 units), in comparison to the control group indicators. Conclusion. Patients with CHD living in low altitudes had prevailing lipid peroxidation processes over antiradical protection factors; inhabitants of mid altitudes had stabilization of the antioxidant system processes. More clear changes were observed among residents of high mountain regions with coronary heart disease. The peroxidation indicators showed prevalence of the formation of toxic products (p<0.001) over the factors contributing to their inactivation and formation of antiradical protection (catalase activity).

coronary heart disease, lipid peroxidation, antioxidant defense, low mountains, middle mountains, high mountains

1. Кулинич В.С. Показатели перекисного окисления липидов и антиоксидантной защиты у больных, работающих в сфере действия ионизирующей радиации, при ИБС на фоне аутоиммунного тиреоидита / В.С. Кулинич // Научные ведомости БелГУ Серия: Медицина. Фармация. - 2014. - №4 (175). - С. 83-88.

2. Каретникова В. Оценка прогноза у больных инфарктом миокарда с подъемом сегмента st и сахарным диабетом 2-го типа / В. Каретникова // Кардиология. - 2013. - №4. - С. 12-18.

3. Хайбуллина З.Р Характеристика метаболических нарушений у больных с различными типами поражения коронарных артерий при ишемической болезни сердца / З.Р.Хайбуллина, Л.Г.Баженов, И.В.Косникова // Вестник НГПУ - 2014. - №5 (21). - С. 137-145.

4. Dontsov A. V The antioxidant effect of dalargin in patients with coronary heart disease and metabolic syndrome. Ekspementalnaya klinicheskaya farmakologiya -Experimental clinical pharmacology, 2015, Vol. 78 (7), pp. 3-6.

5. Young I. S. Antioxidants in health and disease. Journal of Clinical Pathology, 2001, Vol. 54, pp. 176-186.

6. Cheraghi M. Oxidative Stress Status and Liver Markers in Coronary Heart Disease. Inflammation, 2019, Vol. 13, pp. 14.

7. Shahid S. U. The SNP rs10911021 is associated with oxidative stress in coronary heart disease patients from Pakistan. Lipids in health and disease, 2018, Vol. 17, No. 1, pp. 6.

8. Jayne V Dietary Antioxidants and Protection from Coronary Heart Disease. Nutritional Health, 2017, pp. 101-120.

9. Belaia O.L. Lipid peroxidation and antioxidative protection in patients with coronary heart disease. Clinical Medicine, 2009, Vol. 87 (5), pp. 21-4.

10. Sudha J. Antioxidant status and level of oxidants in patients of coronary heart disease. International Journal of Biomedical and Advance Research, 2013, Vol. 4 (11), pp. 824-826.