IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH MYCOTIC DISEASE OF LUNGS

Abstract

Aim. To evaluate the main immunological changes that are specific to fungal lung lesions. Material and methods. The study observation included 90 patients with chronic forms of respiratory diseases with bacteriologically confirmed fungal contamination in a titer of more than 103 CFU. This category ofpatients was classified as a group with lung candidiasis (group 1). To acquire more reliable indicators for comparison, an examination of the 2nd group (50 people) with acute and protracted forms of inflammatory lung diseases without the presence of fungal infection was conducted. Results and discussion. During the lung candidiasis against the background of chronic bronchopulmonary pathology (background diseases), the dynamics of a decrease in the absolute and percent contents of lymphocytes, CD3 + and CD4 + lymphocytes, as well as a slight increase in the number of CD20 lymphocytes, are recorded. This may indicate a decrease in the immunological response and an increase in the duration of the disease, as well as the severity of the main disease. Conclusion: Mycological analysis is necessary during long-term broncho-pulmonary diseases. Positive fungal growth of fungi in the titer of CFU more than 103, immunological studies are rational. The immune response of depression and immunodeficient state that develops with pulmonary candidacies justifies the use of immune-correction therapy in the complex treatment of such patients.