INDICATORS OF INSULIN RESISTANCE DURING THE PREGNANCY

Abstract

Aim. To optimize the approaches to the diagnostics of pathological insulin resistance and associated complications. Materials and methods. Clinical analysis of the pregnancy course and outcomes of 85 patients in various terms of gestation was carried out. Patients were divided into two groups. The test group included 61 patients with risk factors of metabolic disorders during this pregnancy. The comparison group included 24 healthy people without metabolic disorders risk factors. Results and discussion. The index of insulin resistance (HOMA-IR) was measured in various terms. With an increase of the gestation time, the insulin resistance index tended to increase by 2.436±0.96 on 36-38 weeks. It exceeded the value of this index in a standard condition out the pregnancy. In the test group, the index values are 20% more than the standard index values of insulin resistance. Conclusion: Insulin resistance influences pregnancy negatively, causing complications like threatening miscarriage, preeclampsia, chronic placental insufficiency.