IMMUNE SYSTEM STUDY IN NON-GONOCOCCAL URETHRITES

Abstract

Aim. To study the state of general and local immune reactivity in male patients with non-gonococcal urethritis. Materials and methods. 90 men aged 20 to 50 with non-gonococcal urethritis were examined. The test group included 67 patients while the control group included 23 healthy men. The average age of patients in the test group was 27,2+1,7 years and 28, 6 ± 1.6 years in the control group. The diagnosis of non-gonococcal urethritis based on the anamnesis, clinical picture of the disease, and laboratory methods of study. Verification of the non-gonococcal urethritis diagnosis was carried out by direct immunofluorescence methods, polymerase chain reaction, and immune-enzyme methods. Results and discussion. Studies have shown that patients had a decrease in absolute and relative T-lymphocyte values and an increase in relative and absolute B-lymphocyte values. Despite the increased numbers of B-lymphocytes, a significant decline of IgA IgM, and a tendency to decrease of IgG was observed. It was found that in 60.0% ofpatients an increase in Circulating immune complexes, and a decrease in phagocytosis in 50.7% cases and phagocytic activity in 53.7% cases. There was an increase in the number of TNF-a andIL-1f in 61.2% and 56.7% cases respectively, and a decrease in the number of IL-10 in 44.7% of cases. Conclusion. A decrease in the relative and absolute values of T-lymphocyte and an increase in the absolute and relative values of B-lymphocyte were revealed by immunological studies. The analysis showed a significant decrease in IgA and IgM and a tendency to decrease of IgG. A significant decline in phagocytosis was found.