MODERN SCOPE OF TOPICAL TREATMENT OF COMPLICATED FORMS OF DIABETIC FOOT SYNDROME
Abstract
Diabetic foot syndrome is a particular case of a chronic wound. The wound that exists more than four weeks with no signs of active healing is considered chronic. Critical colonization is very important since it is slowing the reparation processes and leads to the chronic transformation of the wound. The rational use of modern methods of local therapy based on scientific research is the key to successful solving of infectious complications of diabetic foot syndrome. Methods of regenerative surgery can close the wound defect even when there is no possibility to implement traditional methods.
About the Authors
M. Н. Nabiev
Department of General Surgery №2. Tajik State Medical University named after Abuali ibni Sino
Tajikistan
Tajikistan
Nabiev Muzaffar Holnazarovich – head of the department
Dushanbe, Rudaki Ave., 139
+992 987256060
D. A. Abdulloev
Department of General Surgery №2. Tajik State Medical University named after Abuali ibni Sino
Tajikistan
Tajikistan
U. M. Begakov
Department of General Surgery №2. Tajik State Medical University named after Abuali ibni Sino
Tajikistan
Tajikistan
References
1. Begakov U. M., Abdulloev D. A., Nabiev M. Kh. Kompleksnoe lechenie oslozhnennykh form sindroma diabeticheskoy stopy [Complex treatment of complicated forms of diabetic foot syndrome]. Zdravookhranenie Tadzhikistana – Tajikistan healthcare, 2013, No. 2 (317), pp. 25.
2. Blinova M. I., Yudintseva N. M., Aleksandrova O. I., Klinicheskiy opyt zazhivleniya troficheskikh yazv s ispolzovaniem kletochnogo produkta «Ekvivalent dermalnyy» [Clinical experience of healing of trophic ulcers using the cellular product "Equivalent dermal"].Zdorove - osnova chelovecheskogo potentsiala: problemy i puti ikh resheniya - Health - the basis of human potential: problems and ways to solve them, 2015, No. 2, pp. 690-694.
3. Vinnik Yu. S., Salmina A. B., Drobushevskaya A. I., Kletochnye tekhnologii i tkanevaya inzheneriya v lechenii dlitelno nezazhivayushchikh ran [.Cell technologies and tissue engineering in the treatment of long-term non-healing wounds]. Vestnik eksperimentalnoy i klinicheskoy khirurgii – Bulletin of experimental and clinical surgery, 2011, No. 2, pp. 392-397
4. Galstyan G. R., Ignateva V. I., Avksenteva M. V., Dedov I. I. Kliniko-ekonomicheskiy analiz primeneniya preparata epidermalnogo faktora rosta (eberprot-p) u bolnykh s sindromom diabeticheskoy stopy [Clinical and economic analysis of the use of epidermal growth factor (eberprot-p) in patients with diabetic foot syndrome]. Endokrinnaya khirurgiya – Endocrine surgery, 2014, No. 1, pp. 4-15.
5. Galimov O. V., Khanov V. O., Sayfullin R. R., Valieva G. R., Okroyan V. P. Sindrom diabeticheskoy stopy: printsipy kompleksnogo lecheniya [Diabetic foot syndrome: principles of comprehensive treatment]. Vestnik khirurgii – Sugery bulletin, 2015, Vol. 174, No. 5, pp. 61-65.
6. Gostishchev V. K., Lipatov K. V., Komarova E. A., Differentsirovannyy podkhod k vyboru kozhnoy plastiki operatsiy u bolnykh s khirurgicheskoy infektsiey [A dif ferentiated approach to the choice of cutaneous surgery in patients with surgical infection]. Khirurgiya - Surgery, 2009, No. 9, pp. 19-24.
7. Grekova N. M., Shishmentsev N. B., Lebedeva Yu. V. Operativnye vmeshatelstva pri sindrome diabeticheskoy stopy: sovremennaya klassifikatsiya i novye tekhnologii [Operative interventions for diabetic foot syndrome: modern classification and new technologies]. Vestnik khirurgii – Surgery bulletin, 2016, Vol. 175, No. 5, pp. 106-109.
8. Dedov I. I., Shestakovoy M. V., Suntsov Yu. I., Rezultaty realizatsii podprogrammy «Sakharnyy diabet» federal'noy tselevoy programmy «Preduprezhdenie i bor'ba s sotsial'no znachimymi zabolevaniyami 2007-2012 gody» [Results of the sub-program "Diabetes" of the federal target program "Prevention and control of socially significant diseases 2007-2012"]. Sakharnyy diabet – Diabetes mielitus, 2013, Vol. 16, No. 25, Spetsvypusk 2, pp. 2-16.
9. Dibirov M. D., Gadzhimuradov R. U., Koreyba K. A. Analiz klinicheskogo primeneniya epidermalnogo faktora rosta eberprot-p i bioplasticheskogo materiala kollost v lechenii defektov myagkikh tkaney u bol'nykh s sindromom diabeticheskoy stopy [Analysis of the clinical application of epidermal growth factor eberprot-p and bioplastic colloquial material in the treatment of soft tissue defects in patients with diabetic foot syndrome]. Khirurgiya – Surgery, 2016, No. 3, pp. 59-63
10. Zinovev E. V., Almazov I. A., Osmanov K. F., Rakhmatullin R. R. Blagopriyatnyy rezultat ispolzovaniya bioplasticheskogo materiala dlya zakrytiya yazvennogo defekta u patsientki s sindromom diabeticheskoy stopy [A favorable result of the use of bioplastic material to close the ulcerative defect in a patient with diabetic foot syndrome]. Vestnik khirurgii – Surgery Bulletin, 2014, Vol. 173, No. 6, pp. 73-74
11. Zorin V. L., Zorina A. I., Petrakova O. S, Dermalnye fibroblasty dlya lecheniya defektov kozhi [Dermal fibroblasts for the treatment of skin defects]. Kletochnaya transplantologiya i tkanevaya inzheneriya - Cell transplan tology and tissue engineering, 2009, No.4, pp. 26-40.
12. Zorin V. L., Zorina A. I., Cherkasov V. R. Analiz zarubezhnogo rynka regenerativnoy meditsiny [Analysis of the foreign market of regenerative medicine]. Kletochnaya transplantologiya i tkanevaya inzheneriya - Cell transplantology and tissue engineering, 2009, No. 3, pp. 68-78.
13. Konenkov V. I., Klimontov V. V. Gennye i kletochnye tekhnologii v lechenii sindroma diabeticheskoy stopy [Genetic and cellular technologies in the treatment of diabetic foot syndrome].Sakharnyy diabet – Diabetes mielitus, 2014, No. 1, pp. 63-69.
14. Koreyba K. A., Kudykin M. N., Minabutdinov A. R. Lechenie ranevykh defektov u bolnykh s neyroishemicheskoy formoy sindroma diabeticheskoy stopy s primeneniem bioplasticheskogo materiala [Treatment of wound defects in patients with a neuroischemic form of diabetic foot syndrome with the use of bioplastic material]. Khirurgiya - Surgery, 2015, No. 7, pp. 69-74.
15. Lapin A. Yu., Skryabin O. N., Rubtsov M. A. Lechenie troficheskikh yazv venoznogo geneza s primeneniem vozmozhnostey kletochnoy terapii [Treatment of trophic ulcer of venous genesis with application of cell ther apy possibilities]. Ambulatornaya khirurgia – Out patients surgery, 2014, No. 1, pp. 5-11.
16. Meltsova A. Zh, Gritsenko V. V., Orlovskiy P. I., Primenenie dermalnykh fibroblastov v kompleksnom lechenii bolnykh s troficheskimi yazvami venoznoy etiologii [The use of dermal fibroblasts in the complex treatment of patients with trophic ulcers of venous etiologiesи]. Vestnik Khirurgii – Sugery bulletin, 2007, No. 1, pp. 72-77.
17. Saidov K. M., Abdulloev D. A., Nabiev M. Kh., Bilolov M. K. Rannyaya diagnostika i profilaktika gnoynykh oslozhneniy amputatsionnoy kul'ti u bol'nykh sakharnym diabetom [Early diagnosis and prevention of purulent complications of amputation stump in patients with diabetes mellitus]. Zdravookhranenie Tadzhikistana – Tajikistan healthcare 2011, No. 2, pp. 43.
18. Saidov K. M., Abdulloev D. A., Nabiev M. Kh., Chakalov T. G. Diagnostika i patogeneticheskoe lechenie oslozhnennykh neyropaticheskikh form sindroma diabet icheskoy stopy [Diagnosis and pathogenetic treatment of complicated neuropathic forms of the diabetic foot syn drome]. Vestnik Avitsenny – Avicenna bulletin, 2012, No. 2 (51), pp. 57-60.
19. Sukovatykh B. S., Pankrusheva T. A., Abramova S. A. Optimizatsiya lecheniya gnoynykh ran u bolnykh s sindromom diabeticheskoy stopy [Optimization of treatment of purulent wounds in patients with diabetic foot syndrome]. Vestnik khirurgii imeni I. I.Grekova – Surgery Bul letin after Grekov, 2014, Vol. 173, No. 3, pp. 28-32.
20. Khramilin V. N. Rol mestnykh sredstv v profilaktike i lechenii infektsionnykh oslozhneniy sindroma diabeticheskoy stopy [The role of local remedies in the prevention and treatment of infectious complications of the diabetic foot syndrome]. Khirurgiya - Хирургия, 2011, No. 10, pp. 78-82.
21. Yarets Yu. I., Novikova I. A. Laboratornyy prognoz riska ottorzheniya autodermotransplantata [Laboratory prognosis of autodermograft rejection risk]. Vestnik khirurgii – Surgery bulletin, 2010, No. 2, pp. 34-38.
22. Altman A. M., Yan Y., Matthias N., IFATS col lection: Human adipose-derived stem cells seeded on a silk fibroin-chitosan scaffold enhance wound repair in a murine soft tissue injuri model. Stem. Cells., 2009, No. 27, pp. 250- 258.,
23. Blanton M. W., Рadad I.. Johnstone B. H., Adipose stromal cells and platelet-ruch plasma therapies sinergisticalli increase revascularization during wound healing. Plast. Reconstr. Surg, 2009, Vol. 123, pp. 56-60.
24. Bushberger B, Follman M., Freyer D. The importance of growth factors for the trteatment of chronic wounds in the case of diabetic foot ulcers. GMS Health Tehnol.Assess., 2010, No. 6, Doc . 12, pp. З3-36.
25. Enoch S., Harding K., Wound Bed Preparation: The Science Behid the Removal of Barriers to Healing. Wounds, 2003, No. 15, Vol 7, pp. 213-229; Surg, 1994, No. 28, Vol. 1, pp. 75-76.
26. European Wound Management Association (EWMA). Position Document; Identifying criteria for wound infection. London: MEP Ltd 2005.
27. Foster T. E. Puskas B. L. Mandelbaun B. R., Plateleth-rich plasma: from basic science to clinical applications. Am. J. Sports. Med., 2009, No. 37, pp. 2259-2272.
28. Gimbl G. M., Кatz A. J., Bunnel B. A., Adipose-derived stem cells for regenerative medicine. Circ. Res, 2007, No. 100, pp. 1249-1260,
29. Hart C. E. Loewen-Rodriguez a. Lessem J. Dermagraft: use in the treatment of chronic wounds care. 2012, Vol. 1, No. 3, pp. 138-141.
30. Huang S. P., Hsu C. C., Chang S. C., Adipose – derived stem cells seeded on acelluar dermal matrix grafts enhance wound healing in a murine model of a fullthickness defect. Ann. Plast. Surg., 2012, No. 69, pp. 656.
31. James G. A., Swogger E., Wolcott R., Biofilms in chronic wounds. Wound Repair Regen, 2008, No. 16, Vol. 1, pp. 37-44.
32. Jadlowiec C. Brenes R. A. li X., Stem cell therapy for critical limb ischemia what can we learn from cell therapy for chronic wounds? Vascular, 2011, Vol. 20, No. 5, pp. 284-289.
33. Karaaltin. M. V, Вaghak S. Adipose derived regenerative cell therapy for treaning a diabetic wound: a case report. Wounds, 2013, No. 112, pp. 536-540,
34. Langer A., Rogowski W. Sistematic review of economic evaluations of human cell-derived wound care products for the treatment of venous leg and diabetic foot ulcers. BMC Health Serv.Resc., 2009, Vol. 9, pp.1-14.
35. Lev-Tov., Li C. S., Dahle S., Isseroff R. R. Cellurar versus acellular matrix devices in treatment of diabetic foot ulcers: study protocol for a comparative efficacy randomized controlled trial. Trial, 2013, No. 14, pp. 1-8.
36. Morbach S., Furchert H.,Groblinghoff U., Long- term prognosis of diabetic foot patients and their limbs: amputation and death over the course of a decade. Diabetes Care, 2012, Vol. 35, No. 10, pp. 2021-2027.
37. Raposio E. Caruana G., Bonomini S., Effective strategy for the isolation of adipose-derived stem cells: minimally manipulated adipose-derived stem cell therapy. Plast. Reconstr. Surg., 2014, No. 133, pp. 1406,
38. Stasch Т., Hoehne J., Huyun T. Autologus fat grafting ( lipofilling) for chronic ulceration on the diabetic foot improves wound healing. IPRAS J., 2013, No. 13, pp. 45-48 .
39. Wolcott R. D., Rhoads D. D., Bennett M. E., Chronic wounds and the medical biofilm paradigm. J Wound Care, 2010, No. 19, Vol. 2, pp. 45-53
40. Chang H. Do В. R., Che J. H., Safety of adiposederrived stem cells and collagenase in fat tissue preparation. Aesthet. Plast. Surg., 2013, No. 37, pp. 802-808.,
Review
For citations:
Nabiev M.Н., Abdulloev D.A., Begakov U.M. MODERN SCOPE OF TOPICAL TREATMENT OF COMPLICATED FORMS OF DIABETIC FOOT SYNDROME. Health care of Tajikistan. 2018;(2):68-75. (In Russ.)
Views:
236
Email this article 