MODERN APPROACHES TO THE TREATMENT OF CHILDREN WITH PERTUSSIS
Abstract
Aim. To assess the clinical and immunological effectiveness of immunomodulating drugs in the treatment of pertussis.
Material and methods. 144 children with a diagnosis of pertussis were observed from birth till the age of 17. Patients were divided into 4 group depending on the method of therapy received. The first group of patients received only basic therapy, the remaining groups in addition to basic therapy received targeted immunomodulators.
Results and its discussion. The comparative assessment of the frequency of the main symptoms of pertussis in the group of patients on immunotherapy, a positive dynamic was found compared with the group of children on basic therapy. In the period of the disease before treatment, the indicators of cellular and humoral immunity in patients of all groups did not significantly differ. In the period of convalescence in all groups of patients receiving immunomodulators, indicators of the cellular and humoral immunity tended to increase with the exception of IgG, which was high in all group.
Conclusion. The use of immunotropic drugs in the treatment of pertussis in children made it possible to achieve an earlier normalization of the main clinical manifestation of pertussis, impaired immunoregulatory mechanisms and cytokine regulation in childre.
About the Authors
M. J. Madzhonovа
SEI Avicenna Tajik State Medical University
Tajikistan
Tajikistan
Department of Pediatric Infectious Diseases
N. M. Khodzhaeva
SEI Avicenna Tajik State Medical University
Tajikistan
Tajikistan
Khodjaeva Nigina Murodovna - Doctor of Medical Sciences, Professor of the Department of Pediatric Infectious Diseases
G. M. Saidmuradova
SEI Avicenna Tajik State Medical University
Tajikistan
Tajikistan
Department of Pediatric Infectious Diseases
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Review
For citations:
Madzhonovа M.J., Khodzhaeva N.M., Saidmuradova G.M. MODERN APPROACHES TO THE TREATMENT OF CHILDREN WITH PERTUSSIS. Health care of Tajikistan. 2020;(3):28-35. (In Russ.)
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