Features of the enzymatic activity of the krebs pathway in lymphocytes in children with iron deficiency anemia
Abstract
Aim. To study the features of the enzymatic activity of the Krebs pathway in peripheral blood lymphocytes in children with iron deficiency anemia (IDA).
Material and methods. 54 children aged 2 to 15 years, suffering from IDA of varying severity were examined. Laboratory data and the cytochemical status of peripheral blood lymphocytes were studied.
Results and discussion. In children suffering from iron deficiency anemia, noticeable changes in laboratory research methods were found: reduction of serum iron, erythrocyte hypochromia, decrease in the average diameter and average volume of erythrocytes, microcytosis, poikilocytosis, hypo-, and dysproteinemia. When analyzing the myelogram, erythrocyte hypochromia and an increase in the number of mitoses of red blood (hyperplasia of the erythroid hematopoietic germ) was found. In addition, the study of the enzymatic status of blood lymphocytes revealed varying degrees of depression of the main enzymes of the Krebs pathway: succinate dehydrogenase (SDH) and alpha-glycerophosphate dehydrogenase (α-GPDH) depending on the severity of the anemic process.
Conclusion. The result of studies of the enzymatic status of blood lymphocytes indicates a decrease in the activity of intracellular dehydrogenases, which are caused by chronic hemic hypoxia and sideropenia in children. The depth of metabolic disorders in sick children was directly proportional to the severity of the anemic process.
About the Authors
S. N. Davlatova
SEI “Avicenna Tajik State Medical University”
Tajikistan
Tajikistan
Davlatova Sohira Nozirovna – Candidate of Medical Sciences; Assistant-professor of the Department of Pediatric Diseases №2
K. I. Ismailov
SEI “Avicenna Tajik State Medical University”
Tajikistan
Tajikistan
Department of Children’s Diseases №2
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Review
For citations:
Davlatova S.N., Ismailov K.I. Features of the enzymatic activity of the krebs pathway in lymphocytes in children with iron deficiency anemia. Health care of Tajikistan. 2020;(4):11-15. (In Russ.)
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