Early diagnostics and prediction of outcomes of craniocerebral injury in patients with cranio-abdominal injuries
Abstract
Aim. To optimize diagnosis and prediction of the outcomes of craniocerebral injuries in patients with cranio-abdominal injuries.
Materials and methods. The work is based on a retrospective analysis of the examination data of 36 patients between 2019-2020. Among the victims, there were 24 men (66.7%), women - 12 (33.3%). Young people (from 18 to 40 years old) made up 48.1%, patients from 41 to 60 years old - 38.5%. There were 13.4% of patients over 60 years old. For the quantitative determination of the S100 protein and NSE parameters, serum or blood plasma is used, analyzed by an enzyme-linked immunosorbent assay using an ELISA diagnostic kit.
Results. The results of the study of the S100 protein and NSE in the blood serum of patients with CAI showed that there is a direct correlation between these parameters with the severity of TBI and the nature of damage to the abdominal organs.
Conclusion. S100 and NSE scores are the most effective markers for early diagnosis and prognosis of TBI in cranio-abdominal injuries.
About the Authors
F. I. Makhmadov
SEI “Avicenna Tajik State Medical University”
Tajikistan
Tajikistan
Makhmadov Farukh Isroilovich - Professor of the Department of Surgical Diseases No. 1; Ph.D.
+992 900 75 44 90
N. O. Rakhimov
SEI “Avicenna Tajik State Medical University”
Tajikistan
Tajikistan
R. M. Berdiev
SEI “Avicenna Tajik State Medical University”
Tajikistan
Tajikistan
M. V. Davlatov
State institution National Medical Center Republic of Tajikistan - “Shifobahsh”; Tajik Institute of postgraduate training of medical staff
Tajikistan
Tajikistan
Sh. A. Abdunazarov
Tajikistan
References
1. Dambinova S. A. Biomarkery tserebralnoy ishemii (razrabotka, issledovanie i praktika) [Biomarkers of cerebral ischemia (design, research and practice)]. St. Petersburg, IPK KOSTA Publ., 2013, 336 p.
2. Pinelis V. G. Biomarkery povrezhdeniya mozga pri cherepno-mozgovoy travme u detey [Biomarkers of brain damage in pediatric brain injury]. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova - Journal of Neurology and Psychiatry named after S.S. Korsakov, 2015, Vol. 115, No. 8, pp. 66-72.
3. Puras Yu. V. Faktory riska razvitiya neblagopriyatnogo iskhoda v khirurgicheskom lechenii ostroy cherepnomozgovoy travmy [Risk Factors for Adverse Outcome in the Surgical Treatment of Acute Craniocerebral Trauma]. Neyrokhirurgiya - Neurosurgery, 2013, No. 2, pp.8-16.
4. Astrand R., Rosenlund C., Unden J. Scandinavian guidelines for initial management of minor and moderate head trauma in children. BMC Medicine, 2016, No.14, pp. 33.
5. Bellander B. M., Olafsson I. H., Ghatan P. H., Bro Skejo H. P., Hansson L. O., Wanecek M., Svensson M. A. Secondary insults following traumatic brain injury enhance complement activation in the human brain and release of the tissue damage marker S100B. Acta Neurochirurgica, 2011, No. 153, pp. 90–100.
6. Bouvier D., Castellani C., Fournier M., Dauphin J. B., Ughetto S., Breton M., Labbe A., Weinberg A. M., Sapin V. Reference ranges for serum S100B protein during the first three years of life. Clinical Biochemistry, 2011, No. 44, pp. 927-929.
7. Ercole A., Thelin E. P., Holst A., Bellander B. M., Nelson D. W. Kinetic modelling of serum S100b after traumatic brain injury. BMC Neurology, 2016, No. 16, pp. 93.
8. Roozenbeek B, Maas AI, Menon DK. Changing patterns in the epidemiology of traumatic brain injury. Nature Reviews Neurology, 2013, No. 9, pp. 231-236.
9. Graham E. M., Burd I., Everett A. D., Northington F. J. Blood. Front Pharmacology, 2016, No. 7, pp. 196.
10. Thelin E. P., Jeppsson E., Frostell A., Svensson M., Mondello S., Bellander B. M., Nelson D. W. Utility of neuron-specific enolase in traumatic brain injury; relations to S100B levels, outcome, and extracranial injury severity. Critical Care, 2016, No. 20, pp. 285.
Review
For citations:
Makhmadov F.I., Rakhimov N.O., Berdiev R.M., Davlatov M.V., Abdunazarov Sh.A. Early diagnostics and prediction of outcomes of craniocerebral injury in patients with cranio-abdominal injuries. Health care of Tajikistan. 2020;(4):34-40. (In Russ.)
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