Surgical correction of focal congenital hyperinsulinism
Abstract
Aim. To determine indications for various methods of surgical correction of focal forms of congenital hyperinsulinism (CH).
Materials and methods. 14 children with focal forms of CH according to PET-CT data, had surgery in the Department of Pediatric Surgery at the V.A. Almazov Scientific Research Center in 2017-03.2019. The data of 2 children out of 14 was doubtful.
Results and discussion. 13 (93%) patients had complete resolution of hyperinsulinism, significant improvement of psychomotor development. 10 (71%) out of 14 children completely recovered. In 1 (7%) patients significant positive dynamics was achieved. 3 (21%) patients required minimum-dose insulin replacement therapy. They were all children with an atypical (mixed adenomatous-diffuse) form of hyperinsulinism.
Conclusions. Partial pancreatectomy is indicated for focal pancreatic lesions with maximal preservation of healthy (according to express biopsy data) gland tissue at any localization of the lesion; in atypical forms, the volume of pancreatectomy is determined individually.
About the Authors
A. A. Sukhotskaya
FGBU “V.A. Almazov National Medical Research Center”
Russian Federation
Russian Federation
Sukhotskaya Anna Andreevna - Candidate of Medical Sciences, Head of the Department of Pediatric Surgery of malformations, Institute of Perinatology and Pediatrics
St. Petersburg
V. G. Bairov
FGBU “V.A. Almazov National Medical Research Center”
Russian Federation
Russian Federation
Department of Pediatric Surgery
St. Petersburg
I. L. Nikitina
FGBU “V.A. Almazov National Medical Research Center”
Russian Federation
Russian Federation
Department of Pediatric Surgery
St. Petersburg
D. V. Ryzhkova
FGBU “V.A. Almazov National Medical Research Center”
Russian Federation
Russian Federation
Department of Pediatric Surgery
St. Petersburg
L. B. Mitrofanova
FGBU “V.A. Almazov National Medical Research Center”
Russian Federation
Russian Federation
Department of Pediatric Surgery
St. Petersburg
B. J. Azizov
Institute of Postgraduate Education in Health Care of the Republic of Tajikistan
Tajikistan
Tajikistan
Department of Pediatric Surgery
Dushanbe
S. A. Amidkhonova
FGBU “V.A. Almazov National Medical Research Center”
Russian Federation
Russian Federation
Department of Pediatric Surgery
St. Petersburg
G. Sh. Bobonazarova
Institute of Postgraduate Education in Health Care of the Republic of Tajikistan
Tajikistan
Tajikistan
Department of Pediatric Surgery
Dushanbe
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Review
For citations:
Sukhotskaya A.A., Bairov V.G., Nikitina I.L., Ryzhkova D.V., Mitrofanova L.B., Azizov B.J., Amidkhonova S.A., Bobonazarova G.Sh. Surgical correction of focal congenital hyperinsulinism. Health care of Tajikistan. 2020;(4):55-60. (In Russ.)
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