The state of the immune system in children with external intestinal sutures
Abstract
Aim. To study the state of the immune system in children with external intestinal suture (EIS).
Material and methods. The immune state of 136 children with EIS of different forms and stages of intoxication was analyzed. 128 (94,1%) children had acquired EIS and 8 (5,9%) had congenital EIS.
They received clinical biochemical, x-ray, ultrasound and immunology tests on hospitalization.
Results. 98 (72,1%) of 136 patients had a decrease of immunoglobulins of all types and high concentration of circulating immune complexes. The decrease of humoral factors of immunity was observed in children with formed therapeutic stomas, sub compensated, compensated EIS and in patients with a presence of complications like dysbacteriosis, inflammation processes in intestine and dermatitis. Cell immunity and factor of protection were decreased in all patients with EIS. The decrease of humoral and cellular immunity in patients with formed EIS and therapeutic stomas was statistically reliably (p<0,05). It had a sufficient correlation (r – 0,67) with indicators in children with uncomplicated therapeutic stomas. In comparison with healthy patients and patients with uncomplicated therapeutic stomas, in patients with unformed and formed EIS it was found significant suppression of T and B-lymphocytes activity as well as T-helpers T-suppressors, natural killers, receptors of apoptosis, receptors for interleukin-2 and transferrin.
Conclusion. The change of cellular and humoral immunity such as decrease of immunoglobulins A, M, and G, the number of B and T-lymphocytes and protection factors, depends on the spread of inflammatory process and level of endogenic intoxication. Direct correlation between the severity of enteral insufficiency, level of endogenic intoxication and damage of hemostasis system, etiology, localization, level, function, and type of EIS was found.
About the Authors
B. J. Azizov
Department of pediatric surgery, anesthesiology, and reanimatology, Institue of postgraduate education in healthcare
Tajikistan
Tajikistan
Dushanbe
H. Ibodov
Department of pediatric surgery, anesthesiology, and reanimatology, Institue of postgraduate education in healthcare
Tajikistan
Tajikistan
Dushanbe
T. SH. Ikromov
Department of pediatric surgery, anesthesiology, and reanimatology, Institue of postgraduate education in healthcare
Tajikistan
Tajikistan
Dushanbe
References
1. Gumerov A. A., Mironov P. I., Viktorov V. V. Metabolicheskie i immunologicheskie izmeneniya pri appendikulyarnom peritonite u detey, oslozhnennom poliorgannoy nedostatochnostyu [Metabolic and immunological changes in children with appendicular peritonitis complicated by multiple organ failure]. Vestnik khirurgii - Herald of surgery, 1997, No. 5, pp. 61-63.
2. Minaev S. V., Nemilova T. K., Knorring G. Yu. Polifermentnaya terapiya v profilaktike spaechnogo protsessa v bryushnoy polosti u detey [Multienzyme therapy in the prevention of adhesions in the abdominal cavity in children]. Vestnik khirurgii - Herald of surgery, 2006, No. 1, pp. 49-54.
3. Moskalenko V. Z., Veselyy S. V., Sopov G. A. Spaechnaya neprokhodimost kishechnika u detey [Adhesive intestinal obstruction in children]. Klinicheskaya khirurgiya – Clinical surgery, 2004, No. 11-12, pp. 72-73.
4. Prutovykh N. N., Arkhipov S. A., Panasenkova N. Yu. Immunologicheskie i biokhimicheskie aspekty formirovaniya spaechnoy bolezni bryushiny u detey [Immunological and biochemical aspects of the formation of peritoneal adhesive disease in children]. Detskaya khirurgiya - Pediatric surgery, 2002, No. 3, pp. 29-33.
5. Sultanov Sh. R., Pulatov Kh. K., Guriev Kh. D. Perekisnoe okislenie lipidov i sostoyanie antioksidantnoy sistemy detey s naruzhnymi kishechnymi svishchami [Lipid peroxidation and the state of the antioxidant system in children with external intestinal fistulas.]. Detskaya khirurgiya - Pediatric surgery, 2015, Vol. 19, No. 5, pp. 19- 22.
6. Khanevich M. D., Dolgikh R. N., Shasholin M. A. Immunokorrektsiya u bolnykh s kolostomami i svishchami [Immunocorrection in patients with colostomas and fistulas]. Vestnik khirurgii - Herald of surgery, 2005, No. 3, pp. 27-29.
7. Shamsiev A. M., Kobilov E. E. Profilaktika spaechnykh oslozhneniy posle operativnykh vmeshatelstv pri appendikulyanom peritonite i ostoroy spaechnoy kishechnoy neprokhodimosti u detey [Prevention of adhesive complications after surgery for appendicular peritonitis and acute adhesive intestinal obstruction in children].Detskaya khirurgiya - Pediatric surgery, 2005, No. 5, pp. 7-9.
8. Alabi А. et al. Preoperative serum levels of serum VEGF-C is associated with distant metastasis in colorectal cancer patients. International Journal of Colorectal Disease, 2009, No. 24, pp. 269-274.
9. Egi H., Okajama M., Hinoi T. et al. Single-incision laparoscopic colectomy using the Gelport system for early colon cancer. Scandinavian Journal of Surgery, 2012, No. 101 (1), pp. 16-20.
Review
For citations:
Azizov B.J., Ibodov H., Ikromov T.Sh. The state of the immune system in children with external intestinal sutures. Health care of Tajikistan. 2018;(3):5-9. (In Russ.)
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