Hepatoprotective properties of ferazon in a combination with lipovital during toxic liver damage by СС14
Abstract
Aim. To study hepatoprotective properties of ferazon in a combination with lipovital during toxic liver damage by СС14.
Materials and methods. The study was conducted on 56 white rats of both sexes weighing 210-220 g. Toxic hepatitis was caused by subcutaneous injection of 50% solution of CC14 on sunflower oil at the rate of 2 ml/kg per day for 1 month. Blood sampling of control and experimental groups was carried after 1 month of the experiment beginning. The drugs were administered intragastrically on a daily basis for 30 days. The animals were divided into the following series: 1 – intact, with intragastric injection of vegetable oil at dose of 2 ml/kg; 2 – control, receiving CC14 at a dose of 2 ml/kg on alternate days for 1 month; 3 and 4 – animals that received СС14 along with intragastric fenazon 0.35 and 0.5 g/kg; 5 – animals treated with fenazon 0.5 g/kg and lipovital 0.02 g/kg; 6 – animals treated with lipovital 0,02 g/kg; 7 animals treated with karsil in a dose of 0.2 g/kg.
Results. Toxic hepatitis of control group animals shows significant (P˂0,001) increase in the activity of cytolytic syndrome markers, cholesterol, as well as an increase in the concentration of bilirubin, total lipids, triglycerides, total protein, albumin, and a decrease in cholesterol and phospholipids composition of blood serum. In the series treated with ferazon in doses of 0.5 g/kg, the activity of ALT and AST in comparison with control animals decreased by 40.43%, 39.9% lipovital by 46.81%, 46% ferazon and lipovital by 49.32%, 49.03% SHF by 34.5% and 44.8%, 46% respectively. Studied drugs in indicated doses in comparison to the control animals significantly ( P < 0.05 - 0,001) decreased the levels of bilirubin, total lipids, triglycerides. They have improved disordered cholesterol, phospholipids, total protein and albumin that was caused by hepatotoxin.
Conclusion. Administration of ferazon in a combination with lipovital during toxic hepatitis shows an explicit hepatoprotective effect in indicated doses as evidenced by improvement of enzymatic, antitoxic, lipid and protein-forming liver function.
Keywords
ferazon,
lipovital,
hepatotoxin,
cytolytic syndrome,
bilirubin,
lipids,
total protein,
enzymes,
hepatoprotective
About the Authors
Kh. A. Ganiev
Central Scientific Research Laboratory of Tajik state medical University after Abuali Ibn Sino
Tajikistan
Tajikistan
Ganiyev Khurshed Abdualimovich – Candidate of Biological Sciences, director
34039, Rudaki av. 139, Dushanbe
D. A. Azonov
Central Scientific Research Laboratory of Tajik state medical University after Abuali Ibn Sino
Tajikistan
Tajikistan
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For citations:
Ganiev Kh.A., Azonov D.A. Hepatoprotective properties of ferazon in a combination with lipovital during toxic liver damage by СС14. Health care of Tajikistan. 2018;(3):27-31. (In Russ.)
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