The study of the effect of transdermal electropharmacological stimulation by valerianaheel on the behavior of rats in various tests

Abstract

Aim. To study the effect of transdermal electro-pharmacological stimulation by Valerianaheel on the behavior of rats in various tests.
Material and methods. The study analyses the effect of physiotherapeutic device “ELAV-8”, constructed by Dr. D.V. Vorobyov, on the behavior of animals in the "Open Field", "Light-dark box" and " Elevated cross-shaped labyrinth " tests. The study suggests a new method of Valerianaheel administration by transdermal electro-pharmacological stimulation with a different current frequency (50 and 100 Hz).
Results. After the administration of the medicament with a current frequency of 100 Hz, animals demonstrated a decrease in a number of defecations (index of emotionality) in the "Open field" test. Use of 50 Hz induced a decrease in grooming by 50%.
In the "Light-dark box" test, 100 Hz of “ELAV-8” device induced an increase of time spent in the light compartment by 31%. It was also found that rats which received Valerianaheel through transdermal electropharmacological stimulation with “ELAV-8” spent less time (36%) in the dark compartment preferring the light compartment of the chamber. The "Elevated cross-shaped labyrinth " test after the application of different frequency current by Valerianaheel showed an increase in activity expressed in a number of over-hangings (by 5% for 50 Hz and by 25% for 100 Hz).
Conclusion. The results of the study suggest that administration of Valerianaheel by transdermal electropharmacological stimulation with “ELAV-8” device induces a decrease in stress level along with stimulation of the exploratory activity of laboratory rats.