Immune status indicators of children with atopic dermatitis
Abstract
Aim. To study the state of cellular and humoral immunity in patients with atopic dermatitis.
Material and methods. 50 patients with atopic dermatitis aged 2-13 were observed. Patients were divided according to severity and the state of the disease. The state of cellular and humoral immunity was studied. The degree of severity was assessed by SCORAD index identification.
Result. The study of cellular and humoral immunity showed that in children with mild disease, Tlymphocyte and their subpopulations slightly deviated from the norm, but tended to decrease in comparison to the control group. Patients with moderate and severe course showed statistically significant (P <0.001) decrease in all parameters of the immune status.
Conclusion. Patients with a moderate and severe course of the disease showed an imbalance in various parts of the immune system. That contributed to the further chronicity of the process. It aggravated the clinical course and worsened the prognosis of the disease, leading to the disruption of compensatory adaptive mechanisms. Secondary immune deficiency increased indicating the need for early diagnosis of the disease and timely administration of etiopathogenetic treatment.
About the Authors
M. P. Nosirova
Department of Family Medicine № 2 Tajik State Medical University after Abuali ibni Sino
Tajikistan
Tajikistan
N. Sh. Abdullaeva
Scientific and Clinical Center of Pediatrics and Pediatric Surgery of the Republic of Tajikistan
Tajikistan
Tajikistan
N. K. Kuzibaevа
Department of Clinical Disciplines, KhSMU
Tajikistan
Tajikistan
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Review
For citations:
Nosirova M.P., Abdullaeva N.Sh., Kuzibaevа N.K. Immune status indicators of children with atopic dermatitis. Health care of Tajikistan. 2018;(3):48-53. (In Russ.)
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