INFLUENCE OF THE INSULIPON ON DISTAL NEUROPATHYIN PATIENTS WITH COMPLICATED FORMS OF THE DIABETIC FOOT SYNDROME

Abstract

Aim. To improve treatment results of patients with complicated neuropathic forms of the diabetic foot syndrome. Material and methods. The results of treatment of 42 patients with complicated neuropathic forms of the diabetic foot syndrome were studied. Patients had diabetes for 10 to 25 years. 24 men (57,2%), and 18 (42,8%) women participated in the study. Patients were divided into two groups: main group - 22 (52,3%); control group 20 (47,7%). The diagnosis was made on the basis of clinical, laboratory and instrumental methods. Results. Patients of the main group received Insulipon along with traditional medicines. 600 mg Insulipon of with 200 ml of 0, 9% physiological solution was applied within 10 days. Afterward, patients took the medicine for 1 month in tablets, one per day. ENMG analyzed the velocity of nerve impulse conduction, latent period and amplitude of m-answer. Electroneuromyography (n=24) allowed revealing deviations in patients with lack of clinical signs of peripheral nervous system damage. The results showed a reduction of impulse conduction velocity and amplitude of m - answer on peroneal and tibial nerves in all patients of the main and control groups. The latent period of lower extremities motor nerves had increased. Conclusion. High frequency of diabetic neuropathy and the decrease of the activity of reparative processes indicate the necessity of inclusion of the neurotrophic medicine Insulipon into comprehensive treatment for patients with complicated forms of diabetic foot syndrome. It increases the velocity of impulse conduction along peroneal and tibial nerves and also reduces the latent period of lower extremities motor nerves that activate processes of wound cleansing and reparation. That reduces the number of amputations and hospital lethality.