Features of morphological changes with fatty hepatosis
https://doi.org/10.52888/0514-2515-2024-360-1-64-70
Abstract
Aim. To study specific morphological changes in liver tissue associated with fatty hepatosis disease.
Material and methods. The initial data for this study were obtained from forensic autopsy reports and liver tissue samples taken from 40 bodies in which the diagnosis of fatty liver disease was morphologically confirmed. Autopsies were performed between 24 and 48 hours after the official determination of death.
Results. With fatty hepatosis, changes include not only an increase in the volume of the organ with a more rounded shape of the edges, but also the acquisition of a bright yellow hue of the liver both on the outer surface and when analyzing its section, as well as a decrease in tissue density. During the histological analysis, it was noted that in all studied samples of liver tissue, significant blood filling was observed in the central veins and sinusoidal capillaries, as well as in the venous vessels of the portal system.
Conclusion. The results of our study confirm that the detected morphological changes in liver tissue are specific signs of fatty hepatosis, which is characterized by the phenomenon of fatty degeneration, intralobular inflammation, fibrosis, steatonecrosis, and most often the presence of large-lobular degeneration is detected.
About the Authors
E. Kh. Tagaykulov
SEI «Avicenna Tajik State Medical University», Department of Pathological Anatomy
Tajikistan
Tajikistan
Tagaikulov Erkin Kholikulovich - Head of the Department.
D. A. Shukurova
SEI «Avicenna Tajik State Medical University», Department of Histology
Tajikistan
Tajikistan
K. A. Zokirova
SEI “Institute of Postgraduate Education in Health Care of the Republic of Tajikistan” Department of Phthisiopulmonology
Tajikistan
Tajikistan
B. G. Muminzoda
SEI «Avicenna Tajik State Medical University», Department of Public Health and Medical Statistics with a Course in History of Medicine
Tajikistan
Tajikistan
Z. A. Gulbekova
SEI «Avicenna Tajik State Medical University», Department of Epidemiology named after Prof. H.K. Rafiev
Tajikistan
Tajikistan
M. T. Mirzoeva
SEI «Avicenna Tajik State Medical University», Department of Histology
Tajikistan
Tajikistan
B. I. Safarov
State educational institution «Avicena Tajik State Medical University», Department of General surgery №1 named after рrofessor A.N. Kakharov
Tajikistan
Tajikistan
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Review
For citations:
Tagaykulov E.Kh., Shukurova D.A., Zokirova K.A., Muminzoda B.G., Gulbekova Z.A., Mirzoeva M.T., Safarov B.I. Features of morphological changes with fatty hepatosis. Health care of Tajikistan. 2024;(1):64-70. (In Russ.) https://doi.org/10.52888/0514-2515-2024-360-1-64-70
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