Results of the application of an antiseptic solution in experimental animals during a simulated intra-abdominal abscess

Aim. To evaluate the role of a 0.1% furagin solution in the treatment of the abscess cavity in experimental animals using a simulated intra-abdominal abscess.
Materials and methods. An experimental study was carried out on 54 chinchilla rabbits weighing 2300-3000 grams. The experimental animals were divided into 3 groups: group 1 - 18 rabbits which received a 0.1% furagin solution for abscess sanitation; group 2 - 18 rabbits with an experimental abscess in which the abscess cavity was sanitised with a 0.02% furacillin solution; group 3 - 18 rabbits with an experimental abscess in which a 0.9% sodium chloride solution was used. After modelling the abscess and sanitising with the indicated solutions, biopsy material taken from the parietal peritoneum and surrounding abscess tissue was subjected to microscopic examination.
Results. No pathological changes were observed when the micro-preparations of healthy experimental animals were examined. When the abscess was modelled, morphological changes were observed in the parietal peritoneum, characterised by a marked enlargement of all the paranasal sinuses. These sinuses were filled with serous fluid in which, on the second or third day after the formation of the abscess, fibrin appeared in large quantities, which contributed to further expansion of the sinuses. At the same time, on the 5-7th day of the postoperative period, a morphological picture of acceleration of reparative processes was observed in the group of animals in which furagin solution was used.
Conclusion. The use of Furagin’s solution in abdominal abscesses in experimental animals allowed to accelerate the reparative processes of the parietal peritoneum, which has a positive effect on the prognosis of the disease.

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