Perinatal outcomes in women with late spontaneous preterm birth depending on gestational age

Aim. To study the perinatal outcomes of women, living in the Khatlon region with late spontaneous preterm birth (LSPB).

Material and methods. 146 women with late spontaneous preterm birth were studied, according to the gestational age at which the birth occurred: subgroup A - gestational age 34 weeks + 6 days (27 women), subgroup B - gestational age 35 weeks + 6 days (51 women), subgroup B – gestational period 36 weeks + 6 days (68 women). Parametric and nonparametric methods of biological statistics (Student and Whitney-Munny tests).

Results. One in five newborns born to mothers with late spontaneous preterm labour was found to be small for gestational age, with fetal growth restriction diagnosed in 75.8% of these cases. A statistically significant reduction in mean Apgar scores at 1 and 5 minutes was observed in neonates born at 34+6 weeks’ gestation. Respiratory failure was the cause of early neonatal mortality in 56.3% of cases. In the structure of early neonatal morbidity, respiratory failure is a leading cause, with its frequency and severity depending on gestational age. A strong inverse correlation was found between gestational age and the incidence of respiratory failure in the early neonatal period in neonates born to mothers with late spontaneous preterm labour and fetal growth restriction.

Conclusion. It is advisable to further conduct research on the effectiveness of differentiated approaches to preventing respiratory distress syndrome in late preterm birth.

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