Prognostic significance of blood lactate clearance in the early postoperative period in elderly patients with metabolic syndrome
https://doi.org/10.52888/0514-2515-2025-364-1-22-28
Abstract
Aim. To evaluate the association of blood lactate clearance with postoperative complications in elderly patients with metabolic syndrome.
Materials and methods. The study was designed as a retrospective, controlled, single-center, observational study in which seventy-six patients were divided into a metabolic syndrome group (n = 38) and a comparison group (n = 38).
Results and discussion. It was found that the incidence of postoperative complications was significantly higher in the metabolic syndrome group (p = 0.005). In addition, the length of stay in the ICU was significantly longer in patients with metabolic syndrome. Lactate concentrations were also statistically significantly higher in the metabolic syndrome group at the time of admission to the ICU and during the first 24 hours after surgery, associated with a significantly lower lactate clearance rate.
Conclusion: Patients with metabolic syndrome experience a higher frequency of perioperative adverse events and require longer postoperative treatment. This is associated with elevated blood lactate levels, highlighting the importance of lactate monitoring in this patient group
About the Authors
I. R. GaleevRussian Federation
Galeev Ildar Rafaelevich Galeev - Assistant of the department of anesthesiology and reanimatology
Ufa
Tel.: +79373181895
T. Sh. Ikromi
Tajikistan
Dushanbe
D. N. Sapronov
Russian Federation
Ufa
P. I. Mironov
Russian Federation
Ufa
References
1. Rekomendatsii ekspertov vserossiyskogo nauchnogo obshchestva kardiologov po diagnostike i lecheniyu metabolicheskogo sindroma (Vtoroy peresmotr) [Expert Recommendations of the All-Russian Scientific Society of Cardiology on the Diagnosis and Treatment of Metabolic Syndrome (Second Revision)]. Prakticheskaya meditsina – Practical medicine, 2010, Vol. 5, No. 4, pp. 81–101.
2. Barnett K, Mercer S.W., Norbury M. B. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet, 2012, No. 380 (9836), pp. 37-43.
3. Salive M.E. Multimorbidity in older adults. Epidemiologic Reviews, 2013, No. 35, pp. 75-83.
4. Aggarwal R., Ostrominski J.W., Vaduganathan M. Prevalence of Cardiovascular-Kidney-Metabolic Syndrome Stages in US Adults, 2011-2020. Journal of the American Medical Association, 2024, pp. e246892.
5. Xu J., Murphy S.L., Kochanek K.D., Arias E. Mortality in the United States, 2021. National Center for Health Statistics, 2022, No. 456, pp. 1-8.
6. Cavalli L., Angehrn L., Schindler C. Number of comorbidities and their impact on perioperative outcome and costs – a single centre cohort study. Swiss Medical Weekly, 2022, No. 152, pp. w30135.
7. Nunes B.P., Flores T.R., Mielke G.I. Multimorbidity and mortality in older adults: A systematic review and meta-analysis. Archives of Gerontology and Geriatrics, 2016, No. 67, pp. 130-138.
8. Hervás M.S., Robles-Hernández D., Serra A. Analysis of Intraoperative Variables Responsible for the Increase in Lactic Acid in Patients Undergoing Debulking Surgery. Journal of Personalized Medicine, 2023, No. 13 (11), pp. 1540.
9. Husain F.A., Martin M.J., Mullenix P.S. Serum lactate and base deficit as predictors of mortality and morbidity The American Journal of Surgery, 2003, No. 185 (5), pp. 485–491.
10. Li S., He T., Shen F. Risk factors for death in elderly patients admitted to intensive care unit after elective abdominal surgery: a consecutive 5-year retrospective study. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, 2021, No. 33 (12), pp. 1453–1458.
11. Darwen C., Bryan A., Quraishi-Akhtar T., Moore J. Postoperative hyperlactataemia and preoperative cardiopulmonary exercise testing in an elective noncardiac surgical cohort: a retrospective observational study. BJA Open, 2023, No. 5, pp. 100124.
Review
For citations:
Galeev I.R., Ikromi T.Sh., Sapronov D.N., Mironov P.I. Prognostic significance of blood lactate clearance in the early postoperative period in elderly patients with metabolic syndrome. Health care of Tajikistan. 2025;(1):22-28. (In Russ.) https://doi.org/10.52888/0514-2515-2025-364-1-22-28