Biomarkers of inflammation, lipid peroxidation, hypoxia and intra-abdominal hypertension in gynecologic peritonitis
https://doi.org/10.52888/0514-2515-2025-367-4-102-111
Abstract
Objective: To evaluate the diagnostic value of biomarkers of inflammation, lipid peroxidation, hypoxia and intraabdominal hypertension in gynecological peritonitis.
Material and methods. Forty-four women with gynecologic peritonitis who underwent emergency laparoscopic peritoneal lavage were examined. Biomarkers of inflammation, oxidative stress, hypoxia and intra-abdominal pressure were determined before the operation, their values were compared with intraoperative findings.
Results: Generalized peritonitis was accompanied by severe inflammatory and metabolic disorders. Levels of malondialdehyde (4.35 [4.00; 4.60] vs 3.25 [2.90; 3.50] nmol/ml) and conjugated dienes (2.92 [2.59; 3.18] vs 2.18 [1.93; 2.43] nmol/ml, p < 0.001) were higher, indicating increased lipid peroxidation. Elevated levels of CRP, IL-6, procalcitonin PCT, and lactate (p < 0.001) indicated activation of the inflammatory cascade and hypoxia. Intra-abdominal pressure in generalized peritonitis (22.70 [21.80; 23.68] vs 11.95 [11.40; 12.97] mmHg, p < 0.001) confirmed the risk of intra-abdominal hypertension and organ dysfunction. More severe systemic inflammation and hypoxia were noted in severe intestinal dilation (p < 0.001).
Conclusion. The severity of gynecological peritonitis correlates with changes in biomarkers of inflammation, lipid peroxidation, hypoxia and intra-abdominal pressure, which emphasizes their diagnostic significance.
About the Authors
K. R. Ruziboyzoda
SEI Avicenna Tajik State Medical University
Tajikistan
Tajikistan
Ruziboyzoda Kahramon Ruziboy – Doctor of Medical Sciences, Professor of the Department of Surgical Diseases No. 1 named after аcademician K.M. Kurbonov
Dushanbe
P. A. Saidzoda
SEI Avicenna Tajik State Medical University; LLC Medical Center “Nasl”
Tajikistan
Tajikistan
Saidzoda Parvina Abdufatokh – correspondence postgraduate student of the Department of Surgical Diseases No. 1 named after аcademician K.M. Kurbonov
Dushanbe
Sh. M. Kurbonov
LLC Medical Center “Nasl”
Tajikistan
Tajikistan
Kurbonov Shamsidin Mirzoevich – MD, PhD, associate professor, obstetrician-gynecologist, reproductologist, founder
Dushanbe
S. G. Ali-Zade
SEI Avicenna Tajik State Medical University
Russian Federation
Russian Federation
Ali-Zade Sukhrob Gaffarovich – MD, PhD, Associate Professor of the Department of Surgical Diseases No. 1 named after Academician K.M. Kurbonov
Dushanbe
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Review
For citations:
Ruziboyzoda K.R., Saidzoda P.A., Kurbonov Sh.M., Ali-Zade S.G. Biomarkers of inflammation, lipid peroxidation, hypoxia and intra-abdominal hypertension in gynecologic peritonitis. Health care of Tajikistan. 2025;(4):102-111. (In Russ.) https://doi.org/10.52888/0514-2515-2025-367-4-102-111
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