ASSESSMENT OF THE STATE OF LIPIDS PEROXIDE OXIDATION AND ANTIOXIDANT CAPACITY OF BLOOD IN PATIENTS WITH UPPER GASTROINTESTINAL BLEEDING DUE TO A PEPTIC ULCER

Abstract

Aim. To improve the outcomes of diagnosis, conservative treatment of acute upper gastrointestinal bleeding due to a peptic ulcer. Material and Methods. 178 patients with acute upper gastrointestinal bleeding due to a peptic ulcer were studied to find the state of the peroxide oxidation state of lipids, antioxidant capacity of the blood, oxygen transportation function of blood, acid-base state, and blood gas composition. Patients were divided into three main groups and each group was divided into two subgroups according to the level of blood loss, amount and character of infusion-transfusion therapy. American surgeons board classification (ATLS2012) was used to find the level of blood loss. Results. Subgroup 1a received 0,9% sodium chloride in an amount of 200% out of the level of blood loss. Subgroup 1b received an infusion of a balanced colloid solution of isotonic Sterofundin. Patients of the 2a subgroup received isotonic Sterofundin in the amount of 200% of blood loss. Besides isotonic Sterofundin patients of the subgroup 2a received modified Gelatine solution - Gelofusin. Patients of 3 a subgroup received the same blood group donor blood and isotonic Sterofundin. Patients of 3b subgroup received isotonic Sterofundin, Gelofusin, blood infusions and individually selected for each patient donor blood products, taking in account disorder on recipients blood hemostasis disorder. Conclusion. The study has shown that the most balanced infusion- perfusion therapy is a technology that was used for the 3b subgroup, that included isotonic Sterofundin, Gelofusin, and individually chosen blood products.