DESIGN AND EFFECTIVENESS OF BROMOTHIADIAZOLPYRIMIDINE OINTMENT IN CLINICAL MEDICINE
Abstract
Aim. To design and to study the therapeutic efficiency of the bromothiadiazolpyrimidine ointment. Material and methods. Following properties of bromothiadiazolpyrimidine ointment were studied: general toxic, allergenic, hepatotoxic, embryotoxic and teratogen, antimicrobial activity. The efficiency of the external application of the bromothiadiazolpyrimidine ointment was also studied. Results. It was found that bromothiadiazolpyrimidine have a wide spectrum of antimicrobial activity, it is a practically nontoxic substance that doesn’t have teratogen effect. The ointment with bromothiadiazolpyrimidine as the active substance in a concentration of 1% is highly effective antibacterial medicine for surface application treating wound infections. Conclusion. The ointment with bromothiadiazolpyrimidine as the active substance in a concentration of 1% is highly effective antibacterial medicine for the surface application that could be administered for a wide range of medical problems.
About the Authors
Z. G. Sangov
Institute of Chemistry named after V. I. Nikitin
Tajikistan
Tajikistan
T. M. Salimov
Institute of Chemistry named after V. I. Nikitin
Tajikistan
Tajikistan
A. Z. Azizov
Institute of Chemistry named after V. I. Nikitin
Tajikistan
Tajikistan
References
1. Ашурова З.Д., Сангов З.Г., Джамшедов Дж.Н., Ашурова М.Д., Мирзоев С., Салимов Т.М., Куканиев М.А. Сроки выведения остаточных количеств препаратов 2-бром-7-метил-5-оксо-5Н-1,3,4-тиадиазоло[3,2-а] пиримидина и 7-метил-5-оксо-5Н-1,3,4-тиадиазоло [3,2-a] пиримидин-2-ил-имидотиокарбамат гидробромида из организма птицы // Веткорм - 2009. - №6. - С. 79.
2. Ашурова З.Д., Сангов З.Г., Джамшедов Дж.Н., Ашурова М.Д., Мирзоев С., Халикова З.Д., Салимов Т.М., Куканиев М.А. Изучение кумулятивных свойств 2-бром-7-метил-5-оксо-5Н-1,3,4-тиадиазоло[3,2-а]пи-римидин и 7-метил-5-оксо-5Н-1,3,4-тиадиазоло[3,2-а] пиримидин-2-ил-имидотиокарбамат гидробромида // Веткорм. - 2009. - №6. - С. 78.
3. Джамшедов Дж.Н., Сангов З.Г., Саид Вали Султан, Салимов Т.М., Ашурова З.Д., Куканиев М.А. Оценка функционального состояния печени после однократного введения производных 1, 3, 4-тиадиазоло [3,2-а] пиримидина белым мышам // Здравоохранение Таджикистана. - 2010. - №3. - С. 17 - 19.
4. Миронова А.Н. Руководство по проведению доклинических исследований лекарственных средств. Часть первая. - М.: Гриф и К, - 2012. - 944 с.
5. Салимов Т.М., Сангов З.Г., Ашурова З.Д., Джамшедов Дж.Н., Куканиев М.А., Ашурова М.Д., Саторов С.С., Хайдаров К.Х. Антимикробная активность 1,3,4-тиадиазоло[3,2-а]пиримидина // Здравоохранение Таджикистана. - 2009. - №3, - С. 173 - 176.
6. Сангов З.Г., Ашурова З.Д., Салимов Т.М., Джамшедов Дж.Н., Лакаев Б., Куканиев М.А., Саторов С.С., Хайдаров К.Х. Фармакокинетика соединений 1,3,4-тиадиазоло [3,2-а] пиримидина // Здравоохранение Таджикистана. - 2009. - №3, - С. 177 - 182.
7. Adnan A. Kadi, Ebtehal S. Al-Abdullah, Ihsan A. Shehata et al. Synthesis, antimicrobial and anti-inflammatory activities of novel 5-(1-adamantyl)-1,3,4-thiadiazole derivatives. European Journal of Medicinal Chemistry, 2010. Vol. 45. P. 5006-5011.
8. Chen H.S., Li Z.M., Han Y.F., Wang Z.W. New fungicidally active pyrazolyl-substituted 1,3,4-thiadiazole compounds and their preparation. Chrese chemical Letters, 1999. Vol. 10(5). P 365-366.
9. Qaremon D.A., Friedman P.A., Remy D.C, Stern A.M. Assignee: Merck & Ch Inc. Methods and Compositions for Thrombolytic Therapy. Patent US 4968494, 1990, Nov. 6
10. Kolavi G., Hegde V., Khazia 1.А., Gadad P Synthesis and evaluation of antitubercular activity of imidazo[2,1-b][1,3,4]thiadiazole derivatives. Bioorg. and Med. Chem, 2006. Vol. 14. P 3069-3080.
11. Hambardzumyan E.N., Vorskanyan A.S., Grigoryan A.A., Yengoyan A.P. Synthesis and biological evaluation of novel nonfused heterocyclic systems derivatives based on 5-(alkylthio)-1, 3, 4-thiadiazole-2(3H)-thions. Journal of Chemical, Biological and Physical Sciences / Section A: Chemical Sciences, 2016. Vol. 6. No.2. pp. 434-444.
Review
For citations:
Sangov Z.G., Salimov T.M., Azizov A.Z. DESIGN AND EFFECTIVENESS OF BROMOTHIADIAZOLPYRIMIDINE OINTMENT IN CLINICAL MEDICINE. Health care of Tajikistan. 2019;(1):50-56. (In Russ.)
Views:
281
Email this article 