Changes in immune status parameters in patients with alopecia areata undergoing combined therapy
https://doi.org/10.52888/0514-2515-2026-368-1-102-109
Abstract
Оbjective: to evaluate the dynamics of immune status parameters in patients with alopecia areata undergoing combined therapy.
Material and methods: a total of 61 individuals were examined, including 30 healthy patients in the control group and 31 patients in the main group. Parameters of cellular and humoral immunity, phagocytic activity, and cytokine profile were assessed before and after treatment. Statistical analysis was performed using Student’s t-test. The results are presented as mean ± standard error (M ± m). Differences were considered statistically significant at p <0.05.
Results: before treatment, the patients showed elevated levels of proinflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-8), increased levels of circulating immune complexes, and reduced cellular immunity indices. After treatment, there was a significant decrease in the levels of proinflammatory cytokines (p < 0.01-0.001), a reduction in circulating immune complex levels (p < 0.05), and an increase in IL-10 levels (p < 0.05) and phagocytic activity (p < 0.05).
Conclusions: combined therapy exerts a pronounced immunomodulatory effect aimed at reducing inflammatory activity and restoring immune homeostasis.
About the Authors
B. I. Saidzodz
Department of Dermatovenereology named after Professor P.T. Zoirov, SEI Avicenna Tajik State Medical University
Tajikistan
Tajikistan
Saidzodz Bahromuddin Ikrom – Doctor of Medical Sciences, Professor of the Department of Dermatovenereology named after Professor P.T. Zoirov, Avicenna Tajik State Medical University
Dushanbe
tel.: +992985154545
A. O. Kasymov
Department of Dermatovenereology with a Course of Cosmetology, SEI Institute of Postgraduate Education in Healthcare of the Republic of Tajikistan
Tajikistan
Tajikistan
Kasymov Abos Olimovich – Candidate of Medical Sciences, Assistant of the Department of Dermatovenereology with a Course in Cosmetology
Dushanbe
N. P. Zoirova
Department of Dermatovenereology named after Professor P.T. Zoirov, SEI Avicenna Tajik State Medical University
Tajikistan
Tajikistan
Zoirova Nuriya Podabonovna – Senior Lecturer of the Department of Dermatovenereology named after Professor P.T. Zoirov
Dushanbe
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Review
For citations:
Saidzodz B.I., Kasymov A.O., Zoirova N.P. Changes in immune status parameters in patients with alopecia areata undergoing combined therapy. Health care of Tajikistan. 2026;(1):102-109. (In Russ.) https://doi.org/10.52888/0514-2515-2026-368-1-102-109
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